Abstract
This chapter gives a brief overview on the currently used physical countermeasures onboard the ISS. Based on recent skeletal muscle research data from our laboratory, we here provide a personal perspective on the still unknown answer how to prevent disused skeletal muscle fibers following gravitational unloading in microgravity from atrophy, for example, by using alternative modes of physical exercise as countermeasure in spaceflight. We still do not know why the outcome of current inflight exercise prescriptions was of little avail to the crew members, and, for example, if optimized, exercise modes targeted to cellular and molecular properties of human skeletal muscle might help to overcome disuse-induced atrophy and impaired performance control of crew members during their long spaceflight missions. Based on the exciting strengthening effects of frequency-controlled vibration mechanosignals on the key cell signaling pathways involved in the structure, function, and free radical stress management of skeletal muscle fibers and neuromuscular synaptic junctions, we propose RVE as an additional highly efficient, short duration, and compliant exercise regimen (with thousands of contraction cycles induced by neuroreflexive muscle stimulation within a few minutes of training bouts) for the safety and health of crew members in preflight training, during spaceflight missions, and during recovery on Earth.
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Alkner BA, Tesch PA (2004) Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise. Eur J Appl Physiol 93:294–305
Blottner D, Salanova M, Püttmann B, Schiffl G, Felsenberg D, Buehring B, Rittweger J (2006) Human skeletal muscle structure and function preserved by vibration muscle exercise following 55 days of bed rest. Eur J Appl Physiol 97:261–271
Casellato C, Tagliabue M, Pedrocchi A, Ferrigno G, Pozzo T (2007) How does microgravity affect the muscular and kinematic synergies in a complex movement? J Gravit Physiol 14(1):93–94
Fitts RH, Riley DR, Widrick JJ (2001) Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol 204:3201–3208
Genc KO, Gopalakrishnan R, Kuklis MM, Maender CC, Rice AJ, Bowersox KD, Cavanagh PR (2010) Foot forces during exercise on the International Space Station. J Biomech 43:3020–3027
Gopalakrishnan R, Genc KO, Rice AJ, Lee SM, Evans HJ, Maender CC, Ilaslan H, Cavanagh PR (2009) Muscle volume, strength, endurance, and exercise loads during 6-month missions in space. Aviat Space Environ Med 81:91–102
Macias BR, Groppo ER, Eastlack RK, Watenpaugh DE, Lee SM, Schneider SM, Boda WL, Smith SM, Cutuk A, Pedowitz RA, Meyer RS, Hargens AR (2005) Space exercise and Earth benefits. Curr Pharm Biotechnol 6:305–317. LBMP as countermeasure
Moriggi M, Vasso M, Fania C, Capitanio D, Bonifacio G, Salanova M, Blottner D, Rittweger J, Felsenberg D, Cerretelli P, Gelfi C (2010) Long term bed rest with and without vibration exercise countermeasures: effects on human muscle protein dysregulation. Proteomics 10:3756–3774
Salanova M, Schiffl G, Püttmann B, Schoser BG, Blottner D (2008) Molecular biomarkers monitoring human skeletal muscle fibres and microvasculature following long-term bed rest with and without countermeasures. J Anat 212:306–318
Salanova M, Schiffl G, Rittweger J, Felsenberg D, Blottner D (2009) Ryanodine receptor type-1 (RyR1) expression and protein S-nitrosylation pattern in human soleus myofibres following bed rest and exercise countermeasure. Histochem Cell Biol 130:105–118
Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy DL, Felsenberg D, Furlan S, Volpe P, Blottner D (2011) Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise. FASEB J 25:4312–4325
Salanova M, Volpe P, Blottner D (2013a) Homer protein family regulation in skeletal muscle and neuromuscular adaptation. IUBMB Life 65:769–776
Salanova M, Schiffl G, Gutsmann M, Felsenberg D, Furlan S, Volpe P, Clarke A, Blottner D (2013b) Nitrosative stress in human skeletal muscle attenuated by exercise countermeasure after chronic disuse. Redox Biol 1:514–526. doi:10.1016/j.redox.2013.10.006
Salanova M, Gelfi C, Moriggi M, Vasso M, Viganò A, Minafra L, Bonifacio G, Schiffl G, Gutsmann M, Felsenberg D, Cerretelli P, Blottner D (2014) Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: Evidence from structural and proteomic analysis. FASEB J 28: 4748–4763
Sun LW, Blottner D, Luan HQ, Salanova M, Wang C, Niu HJ, Felsenberg D, Fan YB (2013) Bone and muscle structure and quality preserved by active versus passive muscle exercise on a new stepper device in 21 days tail-suspended rats. J Musculoskelet Neuronal Interact 13:166–177
Trappe S, Costill D, Gallagher P, Creer A, Peters JR, Evans H, Riley DA, Fitts RH (2009) Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol 106:1159–1168
Watenpaugh DE, O’Leary DD, Schneider SM, Lee SM, Macias BR, Tanaka K, Hughson RL, Hargens AR (2007) Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance. J Appl Physiol 103(6):1964–1972
Witze A (2014) Space-station science ramps up. Nature 510(7504):196–197. doi:10.1038/510196a
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Blottner, D., Salanova, M. (2015). Physical Countermeasure in Space: Efforts in Vain?. In: The NeuroMuscular System: From Earth to Space Life Science. SpringerBriefs in Space Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-12298-4_4
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DOI: https://doi.org/10.1007/978-3-319-12298-4_4
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