Abstract
Hyperthermia for the treatment of resistant tumors has been reported with promising results. Repeated treatment times and applicable for many kinds of cancers are the potential benefits of hyperthermia. Of note is that the success of intracellular hyperthermia is largely dependent on the development of an adequate heat mediator. In this work, we have successfully developed an intracellular hyperthermia system using magnetic hydroxyapatite (mHap) nanocrystals as a thermoseed. After surface modification, poly (ethylene glycol) (PEG) and hyaluronic acid (HA) modified mHap nanocrystals could not only be localized and accumulated in cancer cells, but also efficiently taken up by targeted tumor cells via HA receptor mediated endocytosis process. Furthermore, these Hap-based magnetic nanocrystals may also serve as a tracer for the diagnostic contrast agent under MRI and a drug delivery carrier for therapeutic applications in cancer therapy in vitro and in vivo.
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© 2015 Springer International Publishing Switzerland
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Wu, H.C., Lin, J.Y., Hsieh, S.Y., Wang, T.W., Sun, J.S. (2015). Development and Characterization of Magnetic Bioceramic Nanocrystals for Intracellular Hyperthermia. In: Su, FC., Wang, SH., Yeh, ML. (eds) 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-319-12262-5_2
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DOI: https://doi.org/10.1007/978-3-319-12262-5_2
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12261-8
Online ISBN: 978-3-319-12262-5
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