Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects 0.5 to 1 % of the human population. Gene expression profiling studies of tissues from RA patients showed marked variation in gene expression profiles that allowed identifying distinct molecular disease mechanisms involved in RA pathology. The relative contribution of the different mechanisms may vary among patients and in different stages of disease. Thus, the broad goals of expression profiling in RA are the improvement of understanding of the pathogenic mechanisms underlying RA, the identification of disease subsets and new drug targets and the assessment of disease activity, such as: responsiveness to therapy, overall disease severity and organ specific risk and development of new diagnostic tests. Genetic and environmental factors contribute to the development of this disease and numerous studies have indicated the participation of the major histocompatibility complex (MHC) class II alleles and non-MHC genes. Therefore, identification of the major roles of the participating cells and of candidate genes has been an important subject of study to the understanding of RA pathogenesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adarichev VA, Valdez JC, Bardos T et al (2003) Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol 170(5):2283–2292
Araujo LM, Ribeiro OG, Siqueira M et al (1998) Innate resistance to infection by intracellular bacterial pathogens differs in mice selected for maximal or minimal acute inflammatory response. Eur J Immunol 28(9):2913–2920
Asquith DL, Miller AM, Mcinnes IB et al (2009) Animal models of rheumatoid arthritis. Eur J Immunol 39(8):2040–2044
Ates O, Dalyan L, Musellim B et al (2009) NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Int J Immunogenet 36(1):15–19
Baechler EC, Batliwalla FM, Reed AM et al (2006) Gene expression profiling in human autoimmunity. Immunol Rev 210:120–137
Besenyei T, Kadar A, Tryniszewska B et al (2012) Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models. Clin Dev Immunol. doi:10.1155/2012/284751
Biozzi G, Ribeiro OG, Saran A et al (1998) Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis 19(2):337–346
Cho YG, Cho ML, Min SY et al (2007) Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimmun Rev 7(1):65–70
De Franco M, Colombo F, Galvan A et al (2010) Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis. Cancer Lett 294(2):187–194
De Franco M, Peters LC, Correa MA et al (2014) Pristane-induced arthritis loci interact with the Slc11a1 gene to determine susceptibility in mice selected for high inflammation. PLoS One 9(2):e88302
Donate PB, Fornari TA, Macedo C et al (2013) T cell post-transcriptional miRNA-mRNA interaction networks identify targets associated with susceptibility/resistance to collagen-induced arthritis. PLoS One 8(1):e54803
Filer A, Raza K, Salmon M et al (2008) The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis. Front Biosci 13:2674–2685
Fujikado N, Saijo S, Iwakura Y (2006) Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis. Arthritis Res Ther 8(4):100–125
Galvan A, Vorraro F, Cabrera W et al (2011) Association study by genetic clustering detects multiple inflammatory response loci in non-inbred mice. Genes Immun 12(5):390–394
Glant TT, Finnegan A, Mikecz K (2003) Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics. Crit Rev Immunol 23(3):199–250
Glant TT, Adarichev VA, Nesterovitch AB et al (2004) Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci 327(4):188–195
Hirose J, Tanaka S (2011) Animal models for bone and joint disease. CIA, CAIA model. Clin Calcium 21(2):253–259
Ibanez OM, Stiffel C, Ribeiro OG et al (1992) Genetics of nonspecific immunity: I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness. Eur J Immunol 22(10):2555–2563
Ibrahim SM, Yu X (2006) Dissecting the genetic basis of rheumatoid arthritis in mouse models. Curr Pharm Des 12(29):3753–3759
Ibrahim SM, Mix E, Bottcher T et al. (2001) Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis. Brain 124:1927–1938
Ibrahim SM, Koczan D, Thiesen HJ (2002) Gene-expression profile of collagen-induced arthritis. J Autoimmun 18(2):159–167
Jarvis JN, Frank MB (2010) Functional genomics and rheumatoid arthritis: where have we been and where should we go? Genome Med 2(7):44–59
Jensen JR, Peters LC, Borrego A et al (2006) Involvement of antibody production quantitative trait loci in the susceptibility to pristane-induced arthritis in the mouse. Genes Immun 7(1):44–50
Kannan K, Ortmann RA, Kimpel D (2005) Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 12(3):167–181
Kobezda T, Ghassemi-Nejad S, Mikecz K et al (2014) Of mice and men: how animal models advance our understanding of T-cell function in RA. Nat Rev Rheumatol 10(3):160–170
Kurko J, Besenyei T, Laki J et al (2013) Genetics of rheumatoid arthritis—a comprehensive review. Clin Rev Allergy Immunol 45(2):170–179
Li P, Schwarz EM (2003) The TNF-alpha transgenic mouse model of inflammatory arthritis. Springer Semin Immunopathol 25(1):19–33
Li J, Hsu HC, Mountz JD (2012) Managing macrophages in rheumatoid arthritis by reform or removal. Curr Rheumatol Rep 14(5):445–454
Lubberts E, Koenders MI, Van Den Berg WB (2005) The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 7(1):29–37
Ma Y, Miller JC, Crandall H et al (2009) Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12. Infect Immun 77(8):3302–3311
Patten C, Bush K, Rioja I et al (2004) Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology. Arthritis Rheum 50(10):3334–3345
Peters LC, Jensen JR, Borrego A et al (2007) Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice. Genes Immun 8(1):51–56
Potter M, Wax JS (1981) Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis. J Immunol 127(4):1591–1595
Roper RJ, Weis JJ, Mccracken BA et al (2001) Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun 2(7):388–397
Runstadler JA, Saila H, Savolainen A et al (2005) Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. Arthritis Rheum 52(1):247–256
Silman AJ, Pearson JE (2002) Epidemiology and genetics of rheumatoid arthritis. Arthritis Res 4 (Suppl 3):S265–S272
Silva GL, Junta CM, Sakamoto-Hojo ET et al (2009) Genetic susceptibility loci in rheumatoid arthritis establish transcriptional regulatory networks with other genes. Ann N Y Acad Sci 1173:521–537
Stasiuk LM, Ghoraishian M, Elson CJ et al (1997) Pristane-induced arthritis is CD4+ T-cell dependent. Immunology 90(1):81–86
Teixeira VH, Olaso R, Martin-Magniette ML et al (2009) Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients. PLoS One 4(8):e6803
Thompson SJ, Elson CJ (1993) Susceptibility to pristane-induced arthritis is altered with changes in bowel flora. Immunol Lett 36(2):227–231
Thompson SJ, Rook GA, Brealey RJ et al (1990) Autoimmune reactions to heat-shock proteins in pristane-induced arthritis. Eur J Immunol 20(11):2479–2484
Thompson SJ, Hitsumoto Y, Zhang YW et al (1992) Agalactosyl IgG in pristane-induced arthritis. Pregnancy affects the incidence and severity of arthritis and the glycosylation status of IgG. Clin Exp Immunol 89(3):434–438
Thompson SJ, Francis JN, Siew LK et al (1998) An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis. J Immunol 160(9):4628–4634
Van Den Berg WB (2009) Lessons from animal models of arthritis over the past decade. Arthritis Res Ther 11(5):250–259
Vidal SM, Epstein DJ, Malo D et al (1992) Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1. Genomics 14(1):32–37
Vigar ND, Cabrera WH, Araujo LM et al (2000) Pristane-induced arthritis in mice selected for maximal or minimal acute inflammatory reaction. Eur J Immunol 30(2):431–437
Vorraro F, Galvan A, Cabrera WH et al (2010) Genetic control of IL-1 beta production and inflammatory response by the mouse Irm1 locus. J Immunol 185(3):1616–1621
Weis JJ, Mccracken BA, Ma Y et al (1999) Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol 162(2):948–956
You S, Yoo SA, Choi S et al (2014) Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach. Proc Natl Acad Sci U S A 111(1):550–555
Yu X, Bauer K, Koczan D et al (2007) Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis. Arthritis Res Ther 9(1):3–17
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Ibañez, O., Jensen, J., Franco, M. (2014). Transcriptome Profiling in Experimental Inflammatory Arthritis. In: Passos, G. (eds) Transcriptomics in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-11985-4_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-11985-4_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-11984-7
Online ISBN: 978-3-319-11985-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)