Abstract
α-glucosidase is an enzyme in human encoded by GAA gene [1]. Normally, this enzyme is essential for the degradation of glycogen to glucose in lysosomes. However, with patients of diabetes mellitus type 2, α-glucosidase causes the unwanted elevation of blood glucose level. Therefore, α-glucosidase is now the target of anti-diabetic drugs. In this study, structure of human α-glucosidase was investigated using the approaches of bioinformatics tools. The results from phylogenetic tree also suggest the Mus musculus for animal testing. Finally, some approved α-glucosidase inhibitor drugs from Drugbank database are tested for binding affinity energy and pharmacophore features.
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© 2015 Springer International Publishing Switzerland
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Ong, Q., Le, L. (2015). Comparative Study on Human A-Glucosidase. In: Toi, V., Lien Phuong, T. (eds) 5th International Conference on Biomedical Engineering in Vietnam. IFMBE Proceedings, vol 46. Springer, Cham. https://doi.org/10.1007/978-3-319-11776-8_86
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DOI: https://doi.org/10.1007/978-3-319-11776-8_86
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-11775-1
Online ISBN: 978-3-319-11776-8
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