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The Networking of Chaperones by Co-chaperones pp 179–200Cite as

Co-chaperones of the Mammalian Endoplasmic Reticulum

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 78))

Abstract

In mammalian cells, the rough endoplasmic reticulum or ER plays a central role in the biogenesis of most extracellular plus many organellar proteins and in cellular calcium homeostasis. Therefore, this organelle comprises molecular chaperones that are involved in import, folding/assembly, export, and degradation of polypeptides in millimolar concentrations. In addition, there are calcium channels/pumps and signal transduction components present in the ER membrane that affect and are affected by these processes. The ER lumenal Hsp70, termed immunoglobulin-heavy chain binding protein or BiP, is the central player in all these activities and involves up to seven different co-chaperones, i.e. ER-membrane integrated as well as ER-lumenal Hsp40s, which are termed ERj or ERdj, and two nucleotide exchange factors.

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Acknowledgements

We are grateful to Drs Roland Beckmann (Munich), Gregory L. Blatch (Melbourne, Australia), Adolfo Cavalié (Homburg), Johanna Dudek (Homburg), Friedrich Förster (Martinsried), Markus Greiner (Homburg), Volkhard Helms (Saarbrücken), Stephen High (Manchester, UK), Martin Jung (Homburg), James C. Paton (Adelaide, Australia) Stefan Pfeffer (Martinsried), Albert Sickmann (Dortmund), Jörg Tatzelt (Bochum), Richard Wagner (Osnabrück), and René P. Zahedi (Dortmund) for many years of fruitful collaborations. This work was supported by the Deutsche Forschungsgemeinschaft (DFG).

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  1. Medical Biochemistry & Molecular Biology, Saarland University, D-66421, Homburg, Germany

    Armin Melnyk & Richard Zimmermann

  2. Statistical Physics, Saarland University, D-66123, Saabrücken, Germany

    Heiko Rieger

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  1. Armin Melnyk
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  2. Heiko Rieger
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Correspondence to Richard Zimmermann .

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  1. Victoria University, College of Health and Biomedicine, Melbourne, Victoria, Australia

    Gregory Lloyd Blatch

  2. Department of Biochemistry and Microbiology, Rhodes University, Biomedical Biotechnology Research Unit, Grahamstown, South Africa

    Adrienne Lesley Edkins

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Melnyk, A., Rieger, H., Zimmermann, R. (2015). Co-chaperones of the Mammalian Endoplasmic Reticulum. In: Blatch, G., Edkins, A. (eds) The Networking of Chaperones by Co-chaperones. Subcellular Biochemistry, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-319-11731-7_9

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