Study of The Cytotoxicity of The Nitinol Surface with The Anodic Treatment

  • S. Y. Chen
  • W. C. Wang
  • Y. N. Chen
  • W. J. Shih


Nitinol, the nickel-titanium alloy, is equipped with good physical and mechanical properties and has been used in various medical devices. However, the releasing of the nickel ions causes the immunological problems in the human body that should be seriously considered. This article aims to study the effect of anodic treatment with various voltages on the cytotoxicity of the nitinol surface. The response index used for estimating the cytotoxicity shows high voltage anodic treatment to produce thick oxide layer that prevents the nickel ion from releasing, and greatly reduces the nitinol cytotoxicity.


Cytotoxicity Nitinol Anodic treatment 


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • S. Y. Chen
    • 1
  • W. C. Wang
    • 1
  • Y. N. Chen
    • 1
    • 2
  • W. J. Shih
    • 1
  1. 1.Combination Medical Device Technology SectionMetal Industries Research and Development CentreKaohsiungTaiwan
  2. 2.Department of Biomedical EngineeringNational Cheng Kung UniversityTainanTaiwan

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