Quantitative Online NMR Spectroscopy of Technical Mixtures: On the Fly Quantification of Fluids

  • Michael Neugebauer
  • Nicolai Zientek
  • Michael Maiwald


In this paper quantitative NMR spectroscopy is demonstrated as a tool for process analytical technology (PAT) in order to obtain real time information from dynamic processes. Different methods for quantification are presented and as a result the limit of detection for NMR measurement could be determined to 3.3 mg kg−1 (ethanol in water). As model processes esterification reactions and dissolution of pharmaceutical formulations are presented and important process parameters are extracted. Furthermore it is demonstrated that not only 1H-NMR spectroscopy can be used for process monitoring but also 13C-NMR for technical mixtures.


NMR Quantification Online Process analytical technology 


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The authors kindly thank Bastian Bräuer for sample preparation (methanol in biodiesel), Hugo Ent (VSL) for the kind supply of biodiesel and Andrea Paul for proof reading. We also thank DFG for financial support.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Michael Neugebauer
    • 1
  • Nicolai Zientek
    • 1
  • Michael Maiwald
    • 1
  1. 1.BAM Federal Institute for Materials Research and TestingBerlinGermany

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