Peri-Implant Infections of Oral Biofilm Etiology

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 830)


Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.


Single Nucleotide Polymorphism Dental Implant Gingival Crevicular Fluid Natural Tooth Aerobic Gram Negative Bacillus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Section of Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental MedicineUniversity of ZürichZürichSwitzerland
  2. 2.Department of Oral Microbiology and Immunology, Institute of Odontology, The Sahlgrenska Academy at University of GothenburgGothenburg UniversityGothenburgSweden
  3. 3.Section of Oral Translational Research, Institute of Oral Biology, Center of Dental MedicineUniversity of ZürichZürichSwitzerland
  4. 4.Clinic of Oral Surgery, Center of Dental MedicineUniversity of ZürichZürichSwitzerland

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