Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 830)


Reports of biofilms have increased exponentially in the scientific literature over the past two decades, yet the vast majority of these are basic science investigations with limited clinical relevance. Biofilm studies involving clinical isolates are most often surveys of isolate collections, but suffer from lack of standardization in methodologies for producing and assessing biofilms. In contrast, more informative clinical studies correlating biofilm formation to patient data have infrequently been reported. In this chapter, biofilm surveys of clinical isolates of aerobic and anaerobic bacteria, mycobacteria, and Candida are reviewed, as well as those pertaining to the unique situation of cystic fibrosis. In addition, the influence of host components on in vitro biofilm formation, as well as published studies documenting the clinical impact of biofilms in human infections, are presented.


Cystic Fibrosis Cystic Fibrosis Patient Fibronectin Binding Protein Bloodstream Isolate Multiple Drug Resistant Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the United States Department of the Army or the United States Department of Defense.


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Extremity Trauma and Regenerative Medicine Task AreaUnited States Army Institute of Surgical ResearchHoustonUSA
  2. 2.Infectious Disease ServiceBrooke Army Medical CenterHoustonUSA

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