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Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections

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Biofilm-based Healthcare-associated Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 830))

Abstract

Reports of biofilms have increased exponentially in the scientific literature over the past two decades, yet the vast majority of these are basic science investigations with limited clinical relevance. Biofilm studies involving clinical isolates are most often surveys of isolate collections, but suffer from lack of standardization in methodologies for producing and assessing biofilms. In contrast, more informative clinical studies correlating biofilm formation to patient data have infrequently been reported. In this chapter, biofilm surveys of clinical isolates of aerobic and anaerobic bacteria, mycobacteria, and Candida are reviewed, as well as those pertaining to the unique situation of cystic fibrosis. In addition, the influence of host components on in vitro biofilm formation, as well as published studies documenting the clinical impact of biofilms in human infections, are presented.

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The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the United States Department of the Army or the United States Department of Defense.

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  1. Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, Houston, TX, USA

    Kevin S. Akers & Joseph C. Wenke

  2. Infectious Disease Service, Brooke Army Medical Center, Houston, TX, USA

    Kevin S. Akers, Anthony P. Cardile & Clinton K. Murray

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  1. Microbial Biofilm Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy

    Gianfranco Donelli

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Akers, K.S., Cardile, A.P., Wenke, J.C., Murray, C.K. (2015). Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections. In: Donelli, G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 830. Springer, Cham. https://doi.org/10.1007/978-3-319-11038-7_1

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