Modeling of Testosterone Regulation by Pulse-Modulated Feedback

  • Per Mattsson
  • Alexander Medvedev
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 823)


The continuous part of a hybrid (pulse-modulated) model of testosterone (Te) feedback regulation in the human male is extended with infinite-dimensional and nonlinear blocks, to obtain the dynamics that better agree with the hormone concentration profiles observed in clinical data. A linear least-squares based optimization algorithm is developed for the purpose of detecting impulses of gonadotropin-releasing hormone (GnRH) from measured concentration of luteinizing hormone (LH). The estimated impulse parameters are instrumental in evaluating the frequency and amplitude modulation functions parameterizing the pulse-modulated feedback. The proposed approach allows for the identification of all model parameters from the hormone concentrations of Te and LH. Simulation results of the complete estimated closed-loop system exhibiting similar to the clinical data behavior are provided.


Endocrine systems Modeling Impulse detection Pulsatile feedback Testosterone regulation Time delay Impulsive systems 



This work was in part financed by the European Research Council, Advanced Grant 247035 (SysTEAM) and Grant 2012-3153 from the Swedish Research Council.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Information TechnologyUppsala UniversityUppsalaSweden

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