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Imaging of the Biomaterial Structure and Function

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Biomaterials for Cardiac Regeneration

Abstract

Biomaterials have shown promise for cardiac regenerative therapies as a scaffold to support endogenous and exogenous therapeutic elements. However, the structure and function of biomaterial constructs have not been fully elucidated. Imaging modalities have been applied to investigate scaffold physical structures and cell–scaffold interactions. These modalities are broadly classified depending on the type of energy (optical, ultrasound, X-ray, magnetic, or nuclear) and detection equipment applied to create images. Because each imaging technique has limitations, combining different modalities (e.g., photo-acoustic methods) has been introduced to improve the precision. The selection of the optimal modality for biomaterial imaging depends on the type of biomaterial and also the objectives of the experiment. Optical imaging, for example, has largely been used for in vitro experiments. Longitudinal animal studies, however, require modalities with higher depth of tissue penetration. In this chapter, biomaterial imaging modalities are discussed with a main focus on myocardial regeneration applications.

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Authors and Affiliations

  1. Molecular Function and Imaging Program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada, K1Y 4W7

    Ali Ahmadi, Lisa M. Mielniczuk, Rob S. Beanlands & Robert A. deKemp

  2. Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada, K1Y 4W7

    Ali Ahmadi, Lisa M. Mielniczuk & Rob S. Beanlands

  3. Department of Nuclear Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany

    James T. Thackeray

  4. National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Canada, K1Y 4W7

    Rob S. Beanlands & Robert A. deKemp

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  1. Ali Ahmadi
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  2. Lisa M. Mielniczuk
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  3. James T. Thackeray
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  4. Rob S. Beanlands
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  5. Robert A. deKemp
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Correspondence to Robert A. deKemp .

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Editors and Affiliations

  1. Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Erik J. Suuronen

  2. Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Marc Ruel

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Ahmadi, A., Mielniczuk, L.M., Thackeray, J.T., Beanlands, R.S., deKemp, R.A. (2015). Imaging of the Biomaterial Structure and Function. In: Suuronen, E., Ruel, M. (eds) Biomaterials for Cardiac Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-10972-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-10972-5_9

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