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Whole-Heart Tissue Engineering: Use of Three-Dimensional Matrix Scaffolds

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Biomaterials for Cardiac Regeneration

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Abstract

In front of the actual limitations in the treatment of end-stage HF, there is a clinical demand for alternative therapy concepts in order to further increase clinical outcome and to find customized therapy concepts for patients suffering from end-stage heart failure. With the advance of the tissue engineering concept, new approaches to the treatment of HF are being proposed and scientifically explored. A recently introduced strategy in the tissue engineering field is named whole-organ tissue engineering (WOTE) aiming at the in vitro generation of an entire organ in its anatomic integrity and functional capacity. This chapter is dedicated to cardiac WOTE, also termed whole-heart tissue engineering (WHTE). Beside clinical background and competing experimental approaches this chapter will review current concepts of decellularization, repopulation strategies for whole organ scaffolds, and possible sources of donor cells for organ engineering. Finally, the relevance and feasibility of in vitro conditioning of tissue-engineered whole hearts using bioreactor technology are discussed.

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Authors and Affiliations

  1. Department Cardiovascular Surgery and Research Group for Experimental Surgery, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany

    Hug Aubin, Jörn Hülsmann, Antonio Pinto, Artur Lichtenberg & Payam Akhyari

Authors
  1. Hug Aubin
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  2. Jörn Hülsmann
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  3. Antonio Pinto
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  4. Artur Lichtenberg
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  5. Payam Akhyari
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Corresponding author

Correspondence to Payam Akhyari .

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Editors and Affiliations

  1. Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Erik J. Suuronen

  2. Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Marc Ruel

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Aubin, H., Hülsmann, J., Pinto, A., Lichtenberg, A., Akhyari, P. (2015). Whole-Heart Tissue Engineering: Use of Three-Dimensional Matrix Scaffolds. In: Suuronen, E., Ruel, M. (eds) Biomaterials for Cardiac Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-10972-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-10972-5_7

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  • Online ISBN: 978-3-319-10972-5

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