Abstract
MERTK encodes the widely-expressed tyrosine-protein kinase Mer, which is a receptor tyrosine kinase involved in a signal transduction pathway that regulates numerous cellular processes. In the retina, it is expressed in the RPE and plays a role in the phagocytosis of rod outer segments. Autosomal recessive mutations in MERTK cause retinitis pigmentosa (rod-cone dystrophy) [1–4].
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References
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Zahid, S. et al. (2018). MERTK . In: Retinal Dystrophy Gene Atlas. Springer, Cham. https://doi.org/10.1007/978-3-319-10867-4_46
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DOI: https://doi.org/10.1007/978-3-319-10867-4_46
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