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Non-malignant Brain Tumors

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Emergency Approaches to Neurosurgical Conditions

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Abstract

Non-malignant brain tumors occur at an incidence of 17.9 per 100,000 people in the United States. Low-grade gliomas and benign meningiomas are the most common non-malignant brain tumors in adults. Low-grade gliomas are slow-growing tumors originating from supporting glial cells, while meningiomas grow attached to dural surfaces outside of the brain. Prior radiation exposure is the only known modifiable risk factor. Treatment is focused on decreasing tumor burden, controlling seizures, and decreasing the rate of malignant transformation while preserving neurological function. This is particularly important because patients with non-malignant brain tumors can live for decades with this diagnosis. Surgical resection plays a critical role. Maximal safe resection using techniques such as neuronavigation, functional MRI, diffusion tensor imaging, and direct stimulation mapping allow for preservation of neurological function while reducing tumor burden. Subsequent radiotherapy can improve progression-free survival, particularly for recurrent tumors or residual disease. Targeted chemotherapeutic agents against specific pathways necessary for tumor growth are currently being investigated.

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Abbreviations

CT:

Computed tomography

DTI:

Diffusion tensor imaging

IDH:

Isocitrate dehydrogenase

MRI:

Magnetic resonance imaging

NF2:

Neurofibromatosis type 2

PCV:

Procarbazine carmustine and vincristine

SRS:

Stereotactic radiosurgery

WHO:

World Health Organization

References

  1. Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4(3):316–29.

    PubMed Central  PubMed  Google Scholar 

  2. Barnholtz-Sloan JS, Kruchko C. Meningiomas: causes and risk factors. Neurosurg Focus. 2007;23(4):E2.

    PubMed  Google Scholar 

  3. Bauman G, Fisher B, Watling C, Cairncross JG, Macdonald D. Adult supratentorial low-grade glioma: long-term experience at a single institution. Int J Radiat Oncol Biol Phys. 2009;75(5):1401–7.

    PubMed  Google Scholar 

  4. Baumert BG, Stupp R. Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy. Ann Oncol. 2008;19(7):vii217–22.

    PubMed  Google Scholar 

  5. Berger MS. Lesions in functional (“eloquent”) cortex and subcortical white matter. Clin Neurosurg. 1994;41:444–63.

    CAS  PubMed  Google Scholar 

  6. Blanshard HJ, Chung F, Manninen PH, Taylor MD, Bernstein M. Awake craniotomy for removal of intracranial tumor: considerations for early discharge. Anesth Analg. 2001;92(1):89–94.

    CAS  PubMed  Google Scholar 

  7. Blonski M, Pallud J, Goze C, Mandonnet E, Rigau V, Bauchet L, et al. Neoadjuvant chemotherapy may optimize the extent of resection of World Health Organization grade II gliomas: a case series of 17 patients. J Neurooncol. 2013;113(2):267–75.

    CAS  PubMed  Google Scholar 

  8. Blonski M, Taillandier L, Herbet G, Maldonado IL, Beauchesne P, Fabbro M, et al. Combination of neoadjuvant chemotherapy followed by surgical resection as a new strategy for WHO grade II gliomas: a study of cognitive status and quality of life. J Neurooncol. 2012;106(2):353–66.

    CAS  PubMed  Google Scholar 

  9. Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, et al. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol. 2007;165(1):63–71.

    PubMed  Google Scholar 

  10. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il’yasova D, et al. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008;113(7 Suppl):1953–68.

    PubMed Central  PubMed  Google Scholar 

  11. Brada M, Viviers L, Abson C, Hines F, Britton J, Ashley S, et al. Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas. Ann Oncol. 2003;14(12): 1715–21.

    CAS  PubMed  Google Scholar 

  12. Brenner AV, Linet MS, Fine HA, Shapiro WR, Selker RG, Black PM, et al. History of allergies and autoimmune diseases and risk of brain tumors in adults. Int J Cancer. 2002;99(2):252–9.

    CAS  PubMed  Google Scholar 

  13. Buckner JC, Gesme Jr D, O’Fallon JR, Hammack JE, Stafford S, Brown PD, et al. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. J Clin Oncol. 2003;21(2):251–5.

    CAS  PubMed  Google Scholar 

  14. Capelle L, Fontaine D, Mandonnet E, Taillandier L, Golmard JL, Bauchet L, et al. Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article. J Neurosurg. 2013;118(6):1157–68.

    PubMed  Google Scholar 

  15. Chamberlain MC. Adjuvant combined modality therapy for malignant meningiomas. J Neurosurg. 1996;84(5):733–6.

    CAS  PubMed  Google Scholar 

  16. Chamoun R, Krisht KM, Couldwell WT. Incidental meningiomas. Neurosurg Focus. 2011;31(6):E19.

    PubMed  Google Scholar 

  17. Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, et al. Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer. 2007;110(3):471–6.

    PubMed  Google Scholar 

  18. Coello AF, Moritz-Gasser S, Martino J, Martinoni M, Matsuda R, Duffau H. Selection of intraoperative tasks for awake mapping based on relationships between tumor location and functional networks. J Neurosurg. 2013;119(6):1380–94.

    Google Scholar 

  19. Custer B, Longstreth Jr WT, Phillips LE, Koepsell TD, Van Belle G. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer. 2006;6:152.

    PubMed Central  PubMed  Google Scholar 

  20. Daniels TB, Brown PD, Felten SJ, Wu W, Buckner JC, Arusell RM, et al. Validation of EORTC prognostic factors for adults with low-grade glioma: a report using intergroup 86-72-51. Int J Radiat Oncol Biol Phys. 2011;81(1):218–24.

    PubMed Central  PubMed  Google Scholar 

  21. Davies KG, Maxwell RE, Jennum P, Dhuna A, Beniak TE, Destafney E, et al. Language function following subdural grid-directed temporal lobectomy. Acta Neurol Scand. 1994;90(3):201–6.

    CAS  PubMed  Google Scholar 

  22. De Benedictis A, Moritz-Gasser S, Duffau H. Awake mapping optimizes the extent of resection for low-grade gliomas in eloquent areas. Neurosurgery. 2010;66(6):1074–84.

    PubMed  Google Scholar 

  23. DeAngelis LM. Brain tumors. N Engl J Med. 2001;344(2): 114–23.

    CAS  PubMed  Google Scholar 

  24. Debus J, Wuendrich M, Pirzkall A, Hoess A, Schlegel W, Zuna I, et al. High efficacy of fractionated stereotactic radiotherapy of large base-of-skull meningiomas: long-term results. J Clin Oncol. 2001;19(15):3547–53.

    CAS  PubMed  Google Scholar 

  25. Deorah S, Lynch CF, Sibenaller ZA, Ryken TC. Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus. 2006;20(4):E1.

    PubMed  Google Scholar 

  26. Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol. 2012;14 Suppl 5:v1–49.

    PubMed Central  PubMed  Google Scholar 

  27. Duffau H. Surgery of low-grade gliomas: towards a ‘functional neurooncology’. Curr Opin Oncol. 2009;21(6):543–9.

    PubMed  Google Scholar 

  28. Duffau H. The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery. Cortex. 2013;19(13):00207–4.

    Google Scholar 

  29. Duffau H, Mandonnet E. The “onco-functional balance” in surgery for diffuse low-grade glioma: integrating the extent of resection with quality of life. Acta Neurochir. 2013;155(6):951–7.

    PubMed  Google Scholar 

  30. Englot DJ, Han SJ, Berger MS, Barbaro NM, Chang EF. Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumors. Neurosurgery. 2012;70(4):921–8.

    PubMed  Google Scholar 

  31. FitzGerald DB, Cosgrove GR, Ronner S, Jiang H, Buchbinder BR, Belliveau JW, et al. Location of language in the cortex: a comparison between functional MR imaging and electrocortical stimulation. AJNR Am J Neuroradiol. 1997;18(8):1529–39.

    CAS  PubMed  Google Scholar 

  32. Frazier JL, Johnson MW, Burger PC, Weingart JD, Quinones-Hinojosa A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World Neurosurg. 2010;73(1):53–62.

    PubMed  Google Scholar 

  33. Goldsmith BJ, Wara WM, Wilson CB, Larson DA. Postoperative irradiation for subtotally resected meningiomas. A retrospective analysis of 140 patients treated from 1967 to 1990. J Neurosurg. 1994;80(2):195–201.

    CAS  PubMed  Google Scholar 

  34. Grossman R, Nossek E, Sitt R, Hayat D, Shahar T, Barzilai O, et al. Outcome of elderly patients undergoing awake-craniotomy for tumor resection. Ann Surg Oncol. 2013;20(5):1722–8.

    PubMed  Google Scholar 

  35. Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013;68(8):837–44.

    CAS  PubMed  Google Scholar 

  36. Hardell L, Carlberg M, Hansson MK. Pooled analysis of two case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997-2003. Int Arch Occup Environ Health. 2006;79(8):630–9.

    PubMed  Google Scholar 

  37. Hardell L, Hallquist A, Mild KH, Carlberg M, Pahlson A, Lilja A. Cellular and cordless telephones and the risk for brain tumours. Eur J Cancer Prev. 2002;11(4):377–86.

    CAS  PubMed  Google Scholar 

  38. Hardesty DA, Sanai N. The value of glioma extent of resection in the modern neurosurgical era. Front Neurol. 2012;3:140.

    PubMed Central  PubMed  Google Scholar 

  39. Hatch EE, Linet MS, Zhang J, Fine HA, Shapiro WR, Selker RG, et al. Reproductive and hormonal factors and risk of brain tumors in adult females. Int J Cancer. 2005;114(5):797–805.

    CAS  PubMed  Google Scholar 

  40. Herholz K, Thiel A, Wienhard K, Pietrzyk U, von Stockhausen HM, Karbe H, et al. Individual functional anatomy of verb generation. Neuroimage. 1996;3(3 Pt 1):185–94.

    CAS  PubMed  Google Scholar 

  41. Hirsch J, Ruge MI, Kim KH, Correa DD, Victor JD, Relkin NR, et al. An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery. 2000;47(3):711–21.

    CAS  PubMed  Google Scholar 

  42. Houillier C, Wang X, Kaloshi G, Mokhtari K, Guillevin R, Laffaire J, et al. IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology. 2010;75(17):1560–6.

    CAS  PubMed  Google Scholar 

  43. Hu J, Little J, Xu T, Zhao X, Guo L, Jia X, et al. Risk factors for meningioma in adults: a case-control study in northeast China. Int J Cancer. 1999;83(3):299–304.

    CAS  PubMed  Google Scholar 

  44. Ibebuike K, Ouma J, Gopal R. Meningiomas among intracranial neoplasms in Johannesburg, South Africa: prevalence, clinical observations and review of the literature. Afr Health Sci. 2013;13(1):118–21.

    CAS  PubMed Central  PubMed  Google Scholar 

  45. Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Shapiro WR, Selker RG, et al. Cellular-telephone use and brain tumors. N Engl J Med. 2001;344(2):79–86.

    CAS  PubMed  Google Scholar 

  46. Iwadate Y, Matsutani T, Hasegawa Y, Shinozaki N, Higuchi Y, Saeki N. Favorable long-term outcome of low-grade oligodendrogliomas irrespective of 1p/19q status when treated without radiotherapy. J Neurooncol. 2011;102(3):443–9.

    PubMed  Google Scholar 

  47. Jakola AS, Myrmel KS, Kloster R, Torp SH, Lindal S, Unsgard G, et al. Comparison of a strategy favoring early surgical resection vs a strategy favoring watchful waiting in low-grade gliomas. JAMA. 2012;308(18):1881–8.

    CAS  PubMed  Google Scholar 

  48. Jhawar BS, Fuchs CS, Colditz GA, Stampfer MJ. Sex steroid hormone exposures and risk for meningioma. J Neurosurg. 2003;99(5):848–53.

    CAS  PubMed  Google Scholar 

  49. Johansen C, Boice Jr J, McLaughlin J, Olsen J. Cellular telephones and cancer–a nationwide cohort study in Denmark. J Natl Cancer Inst. 2001;93(3):203–7.

    CAS  PubMed  Google Scholar 

  50. Jukich PJ, McCarthy BJ, Surawicz TS, Freels S, Davis FG. Trends in incidence of primary brain tumors in the United States, 1985-1994. Neuro Oncol. 2001;3(3):141–51.

    CAS  PubMed Central  PubMed  Google Scholar 

  51. Kallio M, Sankila R, Hakulinen T, Jaaskelainen J. Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma. Neurosurgery. 1992;31(1):2–12.

    CAS  PubMed  Google Scholar 

  52. Karim AB, Afra D, Cornu P, Bleehan N, Schraub S, De Witte O, et al. Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BRO4: an interim analysis. Int J Radiat Oncol Biol Phys. 2002;52(2):316–24.

    PubMed  Google Scholar 

  53. Karim AB, Maat B, Hatlevoll R, Menten J, Rutten EH, Thomas DG, et al. A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. Int J Radiat Oncol Biol Phys. 1996;36(3):549–56.

    CAS  PubMed  Google Scholar 

  54. Keles GE, Lundin DA, Lamborn KR, Chang EF, Ojemann G, Berger MS. Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patients. J Neurosurg. 2004;100(3):369–75.

    PubMed  Google Scholar 

  55. Khu KJ, Doglietto F, Radovanovic I, Taleb F, Mendelsohn D, Zadeh G, et al. Patients’ perceptions of awake and outpatient craniotomy for brain tumor: a qualitative study. J Neurosurg. 2010;112(5):1056–60.

    PubMed  Google Scholar 

  56. Kim SS, McCutcheon IE, Suki D, Weinberg JS, Sawaya R, Lang FF, et al. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery. 2009;64(5):836–45.

    PubMed  Google Scholar 

  57. Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW, Burger PC. Histopathology, classification, and grading of gliomas. Glia. 1995;15(3):211–21.

    CAS  PubMed  Google Scholar 

  58. Komotar RJ, Raper DM, Starke RM, Iorgulescu JB, Gutin PH. Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy. J Neurosurg. 2011;115(3):483–90.

    PubMed  Google Scholar 

  59. Kowalik K, Truwit C, Hall W, Kucharczyk J. Initial assessment of costs and benefits of MRI-guided brain tumor resection. Eur Radiol. 2000;10(3):S366–7.

    PubMed  Google Scholar 

  60. Krieg SM, Buchmann NH, Gempt J, Shiban E, Meyer B, Ringel F. Diffusion tensor imaging fiber tracking using navigated brain stimulation–a feasibility study. Acta Neurochir. 2012;154(3):555–63.

    PubMed  Google Scholar 

  61. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95(2):190–8.

    CAS  PubMed  Google Scholar 

  62. Lote K, Egeland T, Hager B, Stenwig B, Skullerud K, Berg-Johnsen J, et al. Survival, prognostic factors, and therapeutic efficacy in low-grade glioma: a retrospective study in 379 patients. J Clin Oncol. 1997;15(9):3129–40.

    CAS  PubMed  Google Scholar 

  63. Lu J, Wu J, Yao C, Zhuang D, Qiu T, Hu X, et al. Awake language mapping and 3-Tesla intraoperative MRI-guided volumetric resection for gliomas in language areas. J Clin Neurosci. 2013;20(9):1280–7.

    PubMed  Google Scholar 

  64. Marta GN, Correa SF, Teixeira MJ. Meningioma: review of the literature with emphasis on the approach to radiotherapy. Expert Rev Anticancer Ther. 2011;11(11):1749–58.

    PubMed  Google Scholar 

  65. McCarthy BJ, Davis FG, Freels S, Surawicz TS, Damek DM, Grutsch J, et al. Factors associated with survival in patients with meningioma. J Neurosurg. 1998;88(5):831–9.

    CAS  PubMed  Google Scholar 

  66. Mirimanoff RO, Dosoretz DE, Linggood RM, Ojemann RG, Martuza RL. Meningioma: analysis of recurrence and progression following neurosurgical resection. J Neurosurg. 1985;62(1):18–24.

    CAS  PubMed  Google Scholar 

  67. Mueller WM, Yetkin FZ, Hammeke TA, Morris 3rd GL, Swanson SJ, Reichert K, et al. Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. Neurosurgery. 1996;39(3):515–20.

    CAS  PubMed  Google Scholar 

  68. Nakamura M, Roser F, Michel J, Jacobs C, Samii M. The natural history of incidental meningiomas. Neurosurgery. 2003;53(1):62–70.

    PubMed  Google Scholar 

  69. Navas-Acien A, Pollan M, Gustavsson P, Plato N. Occupation, exposure to chemicals and risk of gliomas and meningiomas in Sweden. Am J Ind Med. 2002;42(3):214–27.

    PubMed  Google Scholar 

  70. Newton HB, Slivka MA, Stevens C. Hydroxyurea chemotherapy for unresectable or residual meningioma. J Neurooncol. 2000;49(2):165–70.

    CAS  PubMed  Google Scholar 

  71. Nimsky C, Ganslandt O, Tomandl B, Buchfelder M, Fahlbusch R. Low-field magnetic resonance imaging for intraoperative use in neurosurgery: a 5-year experience. Eur Radiol. 2002;12(11):2690–703.

    PubMed  Google Scholar 

  72. Ojemann G, Ojemann J, Lettich E, Berger M. Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. J Neurosurg. 1989;71(3):316–26.

    CAS  PubMed  Google Scholar 

  73. Ojemann GA. Cortical organization of language. J Neurosci. 1991;11(8):2281–7.

    CAS  PubMed  Google Scholar 

  74. Ojemann GA, Whitaker HA. Language localization and variability. Brain Lang. 1978;6(2):239–60.

    CAS  PubMed  Google Scholar 

  75. Pace A, Vidiri A, Galie E, Carosi M, Telera S, Cianciulli AM, et al. Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response. Ann Oncol. 2003;14(12):1722–6.

    CAS  PubMed  Google Scholar 

  76. Pallud J, Blonski M, Mandonnet E, Audureau E, Fontaine D, Sanai N, et al. Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas. Neuro Oncol. 2013;15(5):595–606.

    PubMed Central  PubMed  Google Scholar 

  77. Pallud J, Fontaine D, Duffau H, Mandonnet E, Sanai N, Taillandier L, et al. Natural history of incidental World Health Organization grade II gliomas. Ann Neurol. 2010;68(5):727–33.

    PubMed  Google Scholar 

  78. Phillips LE, Longstreth Jr WT, Koepsell T, Custer BS, Kukull WA, van Belle G. Active and passive cigarette smoking and risk of intracranial meningioma. Neuroepidemiology. 2005;24(3):117–22.

    PubMed  Google Scholar 

  79. Piepmeier J, Christopher S, Spencer D, Byrne T, Kim J, Knisel JP, et al. Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. Neurosurgery. 1996;38(5):872–8.

    CAS  PubMed  Google Scholar 

  80. Potts MB, Smith JS, Molinaro AM, Berger MS. Natural history and surgical management of incidentally discovered low-grade gliomas. J Neurosurg. 2012;116(2):365–72.

    PubMed  Google Scholar 

  81. Prensner JR, Chinnaiyan AM. Metabolism unhinged: IDH mutations in cancer. Nat Med. 2011;17(3):291–3.

    CAS  PubMed  Google Scholar 

  82. Preston-Martin S, Mack W, Henderson BE. Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res. 1989;49(21):6137–43.

    CAS  PubMed  Google Scholar 

  83. Quinones-Hinojosa A, Ojemann SG, Sanai N, Dillon WP, Berger MS. Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area. J Neurosurg. 2003;99(2):311–8.

    PubMed  Google Scholar 

  84. Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, et al. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2514–20.

    CAS  PubMed  Google Scholar 

  85. Recht LD, Lew R, Smith TW. Suspected low-grade glioma: is deferring treatment safe? Ann Neurol. 1992;31(4):431–6.

    CAS  PubMed  Google Scholar 

  86. Repacholi MH, Lerchl A, Roosli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, et al. Systematic review of wireless phone use and brain cancer and other head tumors. Bioelectromagnetics. 2012;33(3):187–206.

    PubMed  Google Scholar 

  87. Rigau V, Zouaoui S, Mathieu-Daude H, Darlix A, Maran A, Tretarre B, et al. French brain tumor database: 5-year histological results on 25 756 cases. Brain Pathol. 2011;21(6):633–44.

    PubMed  Google Scholar 

  88. Ruda R, Bello L, Duffau H, Soffietti R. Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments. Neuro Oncol. 2012;14 Suppl 4:iv55–64.

    CAS  PubMed Central  PubMed  Google Scholar 

  89. Sacko O, Lauwers-Cances V, Brauge D, Sesay M, Brenner A, Roux FE. Awake craniotomy vs surgery under general anesthesia for resection of supratentorial lesions. Neurosurgery. 2011;68(5):1192–8.

    PubMed  Google Scholar 

  90. Sadetzki S, Flint-Richter P, Ben-Tal T, Nass D. Radiation-induced meningioma: a descriptive study of 253 cases. J Neurosurg. 2002;97(5):1078–82.

    PubMed  Google Scholar 

  91. Sanai N, Berger MS. Glioma extent of resection and its impact on patient outcome. Neurosurgery. 2008;62(4):753–64.

    PubMed  Google Scholar 

  92. Sanai N, Berger MS. Operative techniques for gliomas and the value of extent of resection. Neurotherapeutics. 2009;6(3):478–86.

    PubMed  Google Scholar 

  93. Sanai N, Chang S, Berger MS. Low-grade gliomas in adults. J Neurosurg. 2011;115(5):948–65.

    PubMed  Google Scholar 

  94. Sanai N, Mirzadeh Z, Berger MS. Functional outcome after language mapping for glioma resection. N Engl J Med. 2008;358(1):18–27.

    CAS  PubMed  Google Scholar 

  95. Sankila R, Kallio M, Jaaskelainen J, Hakulinen T. Long-term survival of 1986 patients with intracranial meningioma diagnosed from 1953 to 1984 in Finland. Comparison of the observed and expected survival rates in a population-based series. Cancer. 1992;70(6):1568–76.

    CAS  PubMed  Google Scholar 

  96. Saraf S, McCarthy BJ, Villano JL. Update on meningiomas. Oncologist. 2011;16(11):1604–13.

    PubMed Central  PubMed  Google Scholar 

  97. Scerrati M, Roselli R, Iacoangeli M, Pompucci A, Rossi GF. Prognostic factors in low grade (WHO grade II) gliomas of the cerebral hemispheres: the role of surgery. J Neurol Neurosurg Psychiatry. 1996;61(3):291–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  98. Schneider JP, Schulz T, Schmidt F, Dietrich J, Lieberenz S, Trantakis C, et al. Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance. AJNR Am J Neuroradiol. 2001;22(1):89–98.

    CAS  PubMed  Google Scholar 

  99. Schomas DA, Laack NN, Rao RD, Meyer FB, Shaw EG, O’Neill BP, et al. Intracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic. Neuro Oncol. 2009;11(4):437–45.

    PubMed Central  PubMed  Google Scholar 

  100. Schrell UM, Rittig MG, Anders M, Koch UH, Marschalek R, Kiesewetter F, et al. Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea. J Neurosurg. 1997;86(5):840–4.

    CAS  PubMed  Google Scholar 

  101. Seghier ML, Lazeyras F, Pegna AJ, Annoni JM, Zimine I, Mayer E, et al. Variability of fMRI activation during a phonological and semantic language task in healthy subjects. Hum Brain Mapp. 2004;23(3):140–55.

    PubMed  Google Scholar 

  102. Seitz RJ, Huang Y, Knorr U, Tellmann L, Herzog H, Freund HJ. Large-scale plasticity of the human motor cortex. Neuroreport. 1995;6(5):742–4.

    CAS  PubMed  Google Scholar 

  103. Sherman WJ, Raizer JJ. Chemotherapy: what is its role in meningioma? Expert Rev Neurother. 2012;12(10):1189–95.

    CAS  PubMed  Google Scholar 

  104. Simpson D. The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry. 1957;20(1):22–39.

    CAS  PubMed Central  PubMed  Google Scholar 

  105. Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, et al. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008;26(8):1338–45.

    PubMed  Google Scholar 

  106. Steenland K, Boffetta P. Lead and cancer in humans: where are we now? Am J Ind Med. 2000;38(3):295–9.

    CAS  PubMed  Google Scholar 

  107. Stieber VW. Low-grade gliomas. Curr Treat Options Oncol. 2001;2(6):495–506.

    CAS  PubMed  Google Scholar 

  108. Talback M, Stenbeck M, Rosen M. Up-to-date long-term survival of cancer patients: an evaluation of period analysis on Swedish Cancer Registry data. Eur J Cancer. 2004;40(9):1361–72.

    PubMed  Google Scholar 

  109. Taylor MD, Bernstein M. Awake craniotomy with brain mapping as the routine surgical approach to treating patients with supratentorial intraaxial tumors: a prospective trial of 200 cases. J Neurosurg. 1999;90(1):35–41.

    CAS  PubMed  Google Scholar 

  110. Tzourio-Mazoyer N, Josse G, Crivello F, Mazoyer B. Interindividual variability in the hemispheric organization for speech. Neuroimage. 2004;21(1):422–35.

    CAS  PubMed  Google Scholar 

  111. van den Bent MJ, Afra D, de Witte O, Ben Hassel M, Schraub S, Hoang-Xuan K, et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet. 2005;366(9490):985–90.

    PubMed  Google Scholar 

  112. Vranic A, Peyre M, Kalamarides M. New insights into meningioma: from genetics to trials. Curr Opin Oncol. 2012;24(6):660–5.

    CAS  PubMed  Google Scholar 

  113. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765–73.

    CAS  PubMed Central  PubMed  Google Scholar 

  114. You G, Sha ZY, Yan W, Zhang W, Wang YZ, Li SW, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: a clinicopathological study. Neuro Oncol. 2012;14(2):230–41.

    PubMed Central  PubMed  Google Scholar 

  115. Youland RS, Schomas DA, Brown PD, Nwachukwu C, Buckner JC, Giannini C, et al. Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years. Neuro Oncol. 2013;15(8):1102–10.

    CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA

    Shawn L. Hervey-Jumper MD & Mitchel S. Berger MD

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  1. Shawn L. Hervey-Jumper MD
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  2. Mitchel S. Berger MD
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Correspondence to Mitchel S. Berger MD .

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Editors and Affiliations

  1. Neurosurgery/Radiology, Brigham and Women's Medical Hospita Harvard Medical School, Boston, Massachusetts, USA

    Abhishek Agrawal

  2. Department of Neurosurgery, Methodist Neurological Institute, Houston, Texas, USA

    Gavin Britz

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Hervey-Jumper, S.L., Berger, M.S. (2015). Non-malignant Brain Tumors. In: Agrawal, A., Britz, G. (eds) Emergency Approaches to Neurosurgical Conditions. Springer, Cham. https://doi.org/10.1007/978-3-319-10693-9_1

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  • DOI: https://doi.org/10.1007/978-3-319-10693-9_1

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