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Fundamentals of Friction and Wear on the Nanoscale pp 669–697Cite as

Adhesion and Friction Contributions to Cell Motility

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Part of the book series: NanoScience and Technology ((NANO))

Abstract

One challenge in biotribology is a complete explanation of cell motility. As the basic unit of life, cells are complex biological systems. Cells must express genetic information to perform their specialized functions: synthesize, modify, sort, store and transport biomolecule, covert different forms of energy, transduce signals, maintain internal structures and respond to external environments. All of these processes involve mechanical, chemical and physical processes. Mechanical forces play a fundamental role in cell migration, where contractile forces are generated within the cell and pull the cell body forward. On the other side, mechanical forces and deformations induce biological response in cells, and many normal and diseased conditions of cells are dependent upon or regulated by their mechanical environment. The effects of applied forces depend on the type of cells and how the forces are applied on, transmitted into, and distributed within cells. Traction forces exerted by cells on substrates can now be determined with a good degree of accuracy, but the intimate relation between cell shape and traction mechanics requires further qualitative investigation. In this chapter, we overview measurements strategies and the models for quantifying adhesion forces and friction developed during cell-cell and cell-substrate interaction during migration.

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Acknowledgments

MD and OS like to thank the NanoICT Project at the Area della Ricerca di Pisa, CNR.SD greatly thanks Dr. Luisa Trombi for her valuable experimental contribute (stem cell isolation and culture), and the Tuscany Region for financial support (CUCCS/RRMR Project-University of Pisa and Salute 2009 grant).

Author information

Authors and Affiliations

  1. Istituto di Struttura Della Materia, Consiglio Nazionale Delle Ricerche (ISM-CNR), Via Fosso Del Cavaliere 100, 00133, Roma, Italy

    Mario D’Acunto

  2. Istituto di Scienza E Tecnologie Dell’Informazione, Consiglio Nazionale Delle Ricerche, ISTI-CNR, Via Moruzzi 1, 56124, Pisa, Italy

    Mario D’Acunto & Ovidio Salvetti

  3. Department of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy

    Serena Danti

Authors
  1. Mario D’Acunto
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  2. Serena Danti
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  3. Ovidio Salvetti
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Correspondence to Mario D’Acunto .

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Editors and Affiliations

  1. Instituto Madrileño de Estudios Avanzados en Nanociencia, Madrid, Spain

    Enrico Gnecco

  2. University of Basel Department of Physics, Basel, Switzerland

    Ernst Meyer

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D’Acunto, M., Danti, S., Salvetti, O. (2015). Adhesion and Friction Contributions to Cell Motility. In: Gnecco, E., Meyer, E. (eds) Fundamentals of Friction and Wear on the Nanoscale. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-10560-4_29

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