Role of Combined Antioxidants

  • Ashok Agarwal
  • Damayanthi Durairajanayagam
  • Gurpriya Virk
  • Stefan S. Du Plessis
Part of the SpringerBriefs in Reproductive Biology book series (BRIEFSREPROBIO)


Evidence in the literature supported the use of combined antioxidants for the management of free radicals and OS prevention. The effectiveness of combined non-enzymatic antioxidants was investigated in male patients with male factor infertility prior to their third IUI treatment cycle (Dashti et al. 2013). Prior to the treatment, the males were advised to take a combination of tamoxifen 10 mg twice a day, vitamin E 400 IU daily, zinc 15 mg twice a day and selenium 200 mg daily for 3 months. The results of the study detected significant differences in overall values for the four semen parameters (sperm concentration, motility, forward progression and the percentage normal forms) in comparison to the earlier two IUI cycles in the same group. The grouping of the female patients according to their Body Mass Index (BMI) showed crucial differences in pregnancy outcome. The influence of oral antioxidant supplementation on semen quality of IVF patients undergoing IVF/ICSI was analysed in an experiment in which the male patients were supplemented with an oral antioxidant called FertilovitRMplus twice daily for 2 months (Wirleitner et al. 2012). The components of FertilovitRMplus included: Vitamin C 100 mg, Vitamin E 100 mg, Folic acid 500 μg, Zinc 25 mg, Selenium 100 μg, N-acetyl-l-Cysteine 50 mg, l-Carnitine 300 mg, Citrulline 300 mg, Glutathione red 50 mg, Lycopene 4 mg and Coenzyme Q10 15 mg. The results of this study revealed significant reduction in the percentage of immotile sperms in the patients. Additionally, the percentage of class I spermatozoa was significantly higher with drastic improvement in sperm motility as well as in total sperm count.


Folic Acid Male Factor Infertility Total Sperm Count Zinc Therapy Immotile Sperm 
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Copyright information

© The Author 2014

Authors and Affiliations

  • Ashok Agarwal
    • 1
  • Damayanthi Durairajanayagam
    • 2
  • Gurpriya Virk
    • 3
  • Stefan S. Du Plessis
    • 4
  1. 1.Center for Reproductive MedicineCleveland ClinicClevelandUSA
  2. 2.Discipline of Physiology Faculty of MedicineMARA University of TechnologyKuala LumpurMalaysia
  3. 3.MelbourneAustralia
  4. 4.Division of Medical PhysiologyStellenbosch UniversityStellenboschSouth Africa

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