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Human and Mosquito Lysozymes pp 59–65Cite as

Role of Lysozymes of Anopheles Mosquitoes in Plasmodium Development

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Abstract

Lysozymes are important regulators of the immune system in most organisms. These enzymes can show a direct bactericidal activity or upregulate the signaling cascades that result in the production of antimicrobial peptides. In mosquitoes and particularly in the malaria-vector species of the genus Anopheles, lysozymes are present in different tissues and developmental stage expression profiles and are involved in the innate immunity and digestion of bacteria. In An. gambiae, lysozyme C1 protects the oocysts from melanization, thus contributing to an increased prevalence and intensity of Plasmodium berghei infection. The role and importance of lysozymes in the mosquito and in the regulation of oocysts development and the mechanism of action are still unclear.

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Author notes

    Authors and Affiliations

    1. Dipartimento di Medicina Sperimentale, Università degli Studi di Perugia, Perugia, Italy

      Clelia Oliva, Luca Facchinelli & Roberta Spaccapelo

    2. Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milan, Italy

      Nicoletta Basilico

    Authors
    1. Clelia Oliva
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    2. Luca Facchinelli
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    3. Nicoletta Basilico
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    4. Roberta Spaccapelo
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    Corresponding author

    Correspondence to Clelia Oliva .

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    Editors and Affiliations

    1. Neuroscience, University of Torino, Torino, Italy

      Mauro Prato

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    © 2015 Springer International Publishing Switzerland

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    Oliva, C., Facchinelli, L., Basilico, N., Spaccapelo, R. (2015). Role of Lysozymes of Anopheles Mosquitoes in Plasmodium Development. In: Prato, M. (eds) Human and Mosquito Lysozymes. Springer, Cham. https://doi.org/10.1007/978-3-319-09432-8_4

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