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Evolving Additive Tree Model for Inferring Gene Regulatory Networks

  • Guangpeng Li
  • Yuehui Chen
  • Bin Yang
  • Yaou Zhao
  • Dong Wang
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8590)

Abstract

Gene regulatory networks have been studied in the past few years and it is still a hot topic. This paper presents a different evolutionary method for inferring gene regulatory networks (GRNs) using a system of ordinary differential equations (ODEs) as a network model based on time-series microarray data. An evolutionary algorithm based on the additive tree-structure model is applied to identify the structure of the model and genetic algorithm (GA) is used to optimize the parameters of the ODEs. The experimental results show that the proposed method is feasible and effective for inferring gene regulatory networks.

Keywords

Gene Regulatory Networks Evolutionary Algorithms Additive tree model Ordinary differential equations Genetic programming 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Guangpeng Li
    • 1
  • Yuehui Chen
    • 1
  • Bin Yang
    • 1
  • Yaou Zhao
    • 1
  • Dong Wang
    • 1
  1. 1.Computational Intelligence Lab, School of Information Science and EngineeringUniversity of JinanShandongP.R. China

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