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Cardiac PET Imaging in Coronary Artery Disease

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Cardiovascular Imaging

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Abstract

PET is a powerful tool for translational research that offers unique quantitative insights into physiologic and molecular processes in vivo. PET/CT is rapidly advancing our ability to image in great detail the structure and function in the heart and vasculature. By providing concurrent quantitative information about myocardial blood flow and metabolism with coronary and cardiac anatomy, PET/CT offers the opportunity for a comprehensive noninvasive evaluation of the consequences of atherosclerosis in the coronary arteries and the myocardium. Indeed, the quantification of myocardial blood flow (in mL/min/g) and coronary flow reserve provides increased sensitivity for identifying and excluding significant coronary artery stenoses. In addition, coronary flow reserve is a powerful marker of clinical risk, which helps refine clinical risk stratification and, potentially, direct therapy. In addition, PET enables noninvasive assessment of myocardial viability that helps identify myocardial viability and facilitates medical decision making in patients with severe left ventricular dysfunction due to coronary artery disease.

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Authors and Affiliations

  1. Noninvasive Cardiovascular Imaging Program, Departments of Radiology and Medicine; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology; and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, ASB-L1 037C, 75 Francis St, Boston, MA, 02115, USA

    Marcelo F. Di Carli MD

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  1. Marcelo F. Di Carli MD
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Correspondence to Marcelo F. Di Carli MD .

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  1. Cardiovascular Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Elena Aikawa

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Di Carli, M.F. (2015). Cardiac PET Imaging in Coronary Artery Disease. In: Aikawa, E. (eds) Cardiovascular Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-09268-3_14

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