Abstract
Salivary duct carcinoma affects primarily adults and presents at a mean age of approximately 60 years. Women are involved less than men. The majority of cases involve the parotid gland, presenting as single or multiple masses. Most cases of salivary duct carcinoma behave as high-grade malignancies. Salivary duct carcinoma is infiltrative, comprised almost exclusively of one cell type (ductal), and exhibit a variety of architectural patterns (solid, trabecular, cribriform, and microcystic) (Figs. 25.1, 25.2, 25.3, 25.4, 25.5, 25.6, 25.7, 25.8, 25.9, 25.10, 25.11, 25.12, 25.13, 25.14, 25.15, 25.16, 25.17, 25.18, 25.19, 25.20, 25.21, 25.22, 25.23, 25.24, 25.25 and 25.26).
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Salivary duct carcinoma in major and minor salivary glands. J Craniomaxillofac Surg. 1989;17(8):373.
Barnes L, Rao U, Contis L, Krause J, Schwartz A, Scalamogna P. Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein. Oral Surg Oral Med Oral Pathol. 1994a;78(1):74–80.
Barnes L, Rao U, Krause J, Contis L, Schwartz A, Scalamogna P. Salivary duct carcinoma. Part I. A clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature. Oral Surg Oral Med Oral Pathol. 1994b;78(1):64–73.
Brandwein MS, Jagirdar J, Patil J, Biller H, Kaneko M. Salivary duct carcinoma (cribriform salivary carcinoma of excretory ducts). A clinicopathologic and immunohistochemical study of 12 cases. Cancer. 1990;65(10):2307–14.
Delgado R, Vuitch F, Albores-Saavedra J. Salivary duct carcinoma. Cancer. 1993;72(5):1503–12.
Etges A, Pinto DS Jr, Kowalski LP, Soares FA, Araujo VC. Salivary duct carcinoma: immunohistochemical profile of an aggressive salivary gland tumour. J Clin Pathol. 2003;56(12):914–8.
Fan CY, Wang J, Barnes EL. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000;24(4):579–86.
Fan CY, Melhem MF, Hosal AS, Grandis JR, Barnes EL. Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor alpha in salivary duct carcinoma. Arch Otolaryngol Head Neck Surg. 2001;127(9):1075–9.
Fayemi AO, Toker C. Salivary duct carcinoma. Arch Otolaryngol. 1974;99(5):366–8.
Garland TA, Innes DJ Jr, Fechner RE. Salivary duct carcinoma: an analysis of four cases with review of literature. Am J Clin Pathol. 1984;81(4):436–41.
Henley JD, Seo IS, Dayan D, Gnepp DR. Sarcomatoid salivary duct carcinoma of the parotid gland. Hum Pathol. 2000;31:208–13.
Jaehne M, Dippel A, Sagowski C. Salivary duct carcinoma of the submandibular gland. HNO. 2005a;53(11):940–4.
Jaehne M, Roeser K, Jaekel T, Schepers JD, Albert N, Loning T. Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases. Cancer. 2005b;103(12):2526–33.
Jayaprakash V, Merizanu M, Warren GW, Arshad H, Hicks WL Jr, Rigual NR, et al. Survival rates and prognostic factors for infiltrating salivary duct carcinoma: analysis of 228 cases from the surveillance, epidemiology, and end results database. Head Neck. 2014;36:694–701.
Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, et al. Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses. Head Neck. 2014;36:E28–35.
Lewis JE, McKinney BC, Weiland LH, Ferreiro JA, Olsen KD. Salivary duct carcinoma. Clinicopathologic and immunohistochemical review of 26 cases. Cancer. 1996;77(2):223–30.
Martinez-Barba E, Cortes-Guardiola JA, Minguela-Puras A, Torroba-Caron A, Mendez-Trujillo S, Bermejo-Lopez J. Salivary duct carcinoma: clinicopathological and immunohistochemical studies. J Craniomaxillofac Surg. 1997;25(6):328–34.
Masubuchi T, Tada Y, Maruya SI, Osamura Y, Kamata SE, Miura K, et al. Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma. Int J Clin Oncol. 2015;20(1):35–44.
Moriki T, Ueta S, Takahashi T, Mitani M, Ichien M. Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis. Cancer. 2001;93(5):344–50.
Nabili V, Tan JW, Bhuta S, Sercarz JA, Head CS. Salivary duct carcinoma: a clinical and histologic review with implications for trastuzumab therapy. Head Neck. 2007;29(10):907–12.
Nagao T, Gaffey TA, Visscher DW, Kay PA, Minato H, Serizawa H, et al. Invasive micropapillary salivary duct carcinoma: a distinct histologic variant with biologic significance. Am J Surg Pathol. 2004;28(3):319–26.
Ponniah I, Murali GM, SureshKumar P, Kumaran MG, Shaheen A. Salivary duct carcinoma of the palate. Indian J Dent Res. 2005;16(4):167–70.
Roh JL, Cho KJ, Kwon GY, Choi SH, Nam SY, Kim SY. Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma. J Surg Oncol. 2008;97(7):596–600.
Shimizu A, Yamane M, Ito H, Araki S, Yoshida T, Suzuki M. Clinicopathological study of salivary duct carcinoma. Nihon Jibiinkoka Gakkai Kaiho. 2002;105(6):727–31.
Simpson RH. Salivary duct carcinoma: new developments-morphological variants including pure in situ high-grade lesions: proposed molecular classification. Head Neck Pathol. 2013;7(Suppl 1):S48–58.
Simpson RHW, Desai S, Di Palma S. Salivary duct carcinoma in situ of the parotid gland. Histopathology. 2008;53(4):416–25.
Skalova A. Starek, Kucerova V, Szepe P, plank L. salivary duct carcinoma—a highly aggressive salivary gland tumor with HER-2/neu oncoprotein overexpression. Pathol Res Pract. 2001;197(9):621–6.
Skalova A, Starek I, Vanecek T, Kucerova V, Plank L, Szepe P. Amplification and overexpression of HER-2/neu in parotid gland salivary duct carcinoma. Immunohistochemical study and fluorescence in situ hybridization. Cesk Patol. 2002;38(Suppl 1):27–34.
Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, et al. Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression. Am J Surg Pathol. 2015;39:705–13.
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García, J.J. (2019). Salivary Duct Carcinoma. In: Atlas of Salivary Gland Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-09021-4_25
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DOI: https://doi.org/10.1007/978-3-319-09021-4_25
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