Abstract
The major problem when treating nail psoriasis is either the difficulty of the topical medications to present their therapeutic efficacy or the side effects of the systematically administrated drugs.
Topical medications must penetrate the nail plate which in normal conditions presents unique barrier properties, taking in consideration also that in psoriasis it can be thickened due to the hyperkeratosis of the nail bed, increasing difficulties in acting properly.
Systemic drugs have three major problems. The first has to deal with side effects of these drugs, the second with interactions with other systemic medications that these patients are probably receiving, and the third with the lack of on-label indication for nail psoriasis. The latter is a major problem when the patient has isolated nail involvement.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Haffez F, Hui X, Selner M, et al. Ciclopirox delivery into the human nail plate using novel lipid diffusion enhancers. Drug Dev Ind Pharm. 2013;19:21–32.
Palliyi B, Lebo DB, Patel PR. A preformulation strategy for the selection of penetration enhancers for a transungual formulation. AAPS PharmSciTech. 2013;14(2):682–91.
Nair AB, Chakraborty B, Murthy SN. Effect of polyethylene glycols on the trans-ungual delivery of terbinafine. Curr Drug Deliv. 2010;7(5):407–14.
Vejnovic I, Huonder C, Betz G. Permeation studies of novel Terbinafine formulations containing hydrophobins through human nails in vitro. Int J Pharm. 2010;397(1–2):67–76.
Vaka SR, Murthy SN, O’Haver JH, et al. A platform for predicting and enhancing model drug delivery across the human nail plate. Drug Dev Ind Pharm. 2011;37(1):72–9.
Nogueiras-Nieto L, Delgado-Charro M, Otero-Espinar FJ. Thermogelling hydrogels of cyclodextrins/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: application to the delivery of triamcinolone acetonide and ciclopirox olamine. Eur J Pharm Biopharm. 2013;83(3):370–7.
Nair AB, Sammeta SM, Vaka SR, et al. A study on the effect of inorganic salts in transungual drug delivery of terbinafine. J Pharm Pharmacol. 2009;61(4):431–7.
Brown MB, Khengar RH, Turner RB, et al. Overcoming the nail barrier: a systematic investigation of ungula chemical penetration enhancement. Int J Pharm. 2009;370(1–2):61–7.
Abadi D, Zderic V. Ultrasound-mediated nail drug delivery system. J Ultrasound Med. 2011;30(12):1723–30.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Rigopoulos, D., Tosti, A. (2014). What Is the Future?. In: Rigopoulos, D., Tosti, A. (eds) Nail Psoriasis. Springer, Cham. https://doi.org/10.1007/978-3-319-08810-5_16
Download citation
DOI: https://doi.org/10.1007/978-3-319-08810-5_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08809-9
Online ISBN: 978-3-319-08810-5
eBook Packages: MedicineMedicine (R0)