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The Multiple Actions of the Insulin-Like Growth Factor-I Signaling in the Myocardium

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Introduction to Translational Cardiovascular Research

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Abstract

The insulin-like growth factor-I (IGF-I) is an important growth factor which regulates a variety of cellular responses and has important roles in multiple biological systems. IGF-I is produced by many tissues including the myocardium, indicating that a significant component of its action is due to an autocrine and paracrine mode of function. Multiple transcripts of the Igf1 gene code for several precursor polypeptides (isoforms). IGF-I actions are mediated through its binding to several cell-membrane receptors, inducing cell proliferation, differentiation, migration and survival, and implicating this growth factor in mitogenic, myogenic and anti-apoptotic processes in cardiac muscle. In this chapter, focus has been driven on the signaling pathways that IGF-I triggers in the regulation of physiological and pathophysiological processes during cardiac hypertrophy, regeneration and remodeling. The concept of a potentially differential bioactivity and signaling of the different IGF-I peptides in the myocardium is also discussed.

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Abbreviations

Akt:

Protein kinase B

ALS:

Acid-labile subunit

AMPK:

AMP-activated protein kinase

APO:

Apoptosis

ERKs:

Extracellular signal-regulated kinases

GH:

Growth hormone

GPCRs:

G-protein coupled receptors

Grb2:

Growth receptor binding protein 2

HGF:

Hepatocyte growth factor

HSP60:

Heat shock protein 60

IGFBPs:

IGF binding proteins

IGF-I:

Insulin-like growth factor-I

IGF-IEa:

IGF-IEa isoform

IGF-IEb:

IGF-IEb isoform

IGF-IIR:

Type 2 IGF receptor

IGF-IR:

Type 1 IGF receptor

IR:

Insulin receptor

IRS:

Insulin receptor substrate proteins

JNK1:

c-Jun N-terminal kinase 1

MAPKs:

Mitogen-activated protein kinases

MGF:

Mechano-growth factor

MSCs:

Mesenchymal stem cells

mTOR:

Mammalian target of rapamycin

PDK1:

Phosphoinositide-dependent kinase-1

PI3-K:

Phosphatidylinositol 3-kinase

REG:

Regeneration

SGK1:

Serum/glucocorticoid regulated kinase 1

SH2:

Src homology 2

Shc:

Src homology/collagen

siRNA:

Small interfering RNA

SirT1:

Sirtuin 1

Sos:

Son of Sevenless

TGF-β1 :

Transforming growth factor beta 1

uPA:

Urokinase-type plasminogen activator

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Authors and Affiliations

  1. Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Micras Asias, Goudi-Athens, 115 27, Greece

    Anastassios Philippou & Michael Koutsilieris MD, PhD

  2. Department of Sports Medicine and Biology of Physical Activity, Faculty of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece

    Maria Maridaki

  3. Second Department of Propaedeutic Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Theodore Karatzas

Authors
  1. Anastassios Philippou
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  2. Maria Maridaki
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  3. Theodore Karatzas
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  4. Michael Koutsilieris MD, PhD
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Corresponding author

Correspondence to Michael Koutsilieris MD, PhD .

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Editors and Affiliations

  1. Academy of Athens, Biomedical Research Foundation, Athens, Greece

    Dennis V. Cokkinos

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Philippou, A., Maridaki, M., Karatzas, T., Koutsilieris, M. (2015). The Multiple Actions of the Insulin-Like Growth Factor-I Signaling in the Myocardium. In: Cokkinos, D. (eds) Introduction to Translational Cardiovascular Research. Springer, Cham. https://doi.org/10.1007/978-3-319-08798-6_11

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  • DOI: https://doi.org/10.1007/978-3-319-08798-6_11

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