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Theory of Hematopoiesis Control pp 27–32Cite as

Disturbances in Hemopoietic Control During Neurotic Disorders

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Part of the book series: SpringerBriefs in Cell Biology ((SBCB,volume 5))

Abstract

At present, the experimental models of neurotic disorders have been developed, which are sufficiently good to reproduce clinical presentation of some neurosis forms, thereby opening the way to examine the pharmacological effects of antineurotic drugs. One of the popular models of a neurotic stimulation is the conflict situation based on ‘collision’ of the defensive and food-procuring reflexes, which in many respects is comparable to situation of uncertainty and to the state of insurmountable or difficult obstacle in humans [116, 161]. Another example of such models is deprivation of the paradoxical sleep, which exerts specific (first of all, in relation to memory and cognitive functions) asthenizing effect on CNS, because the paradoxical phase of sleep plays the key role in information processing [11, 66, 117, 282]. The sleep requirements result from necessity to block the sensory input in order to process and integrate the daily portion of information obtained by the brain. This model simulates many features of CNS asthenization provoked in patients by diverse pathologies including the neurotic disorders resulting from sleep deprivation. Moreover, deprivation of the paradoxical sleep shapes the peculiar state of CNS, which inhibits the active search behavior in wakeful animals. Under sleep deprivation model, the animal cannot compensate this behavioral abnormality by normal paradoxical sleep. The long-term deficiency in search activity culminates in the death of animals [117].

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References

  1. Brodskiĭ VI, Gusatinskiĭ VN, Kogan AB, Nechaeva NV (1974) Variations in the intensity of H3-leucine incorporation into proteins during slow-wave and paradoxical phases of natural sleep in the cat associative cortex. Dokl Akad Nauk SSSR 215:748–750

    PubMed  Google Scholar 

  2. Gol’dberg ED, Dygaĭ AM, Zhdanov VV, Khlusov IA (1999) Dynamic theory of hemopoiesis. Byull Eksp Biol Med 127(5):484–494

    Google Scholar 

  3. Gol’dberg ED, Dygai AM, Provalova NV et al (2004) The role of nervous system in hemopoietic control [in Russian]. TGU, Tomsk, p 146

    Google Scholar 

  4. Gol’dberg ED, Dygai AM, Skurikhin EG et al (2000) Adrenergic and cholinergic mechanisms of hemopoiesis regulation during experimental neuroses. Byull Eksp Biol Med 129(4):381–385

    Google Scholar 

  5. Skurikhin EG, Pershina OV, Stavrova LA et al (2005) Neurosis-associated changes in the granulocytic hemopoietic stem in mice with different learning capacity. Byull Eksp Biol Med 140(8):136–141

    Google Scholar 

  6. Gol’dberg ED, Dygai AM, Sherstoboev EY (2000) The mechanisms of local hemopoietic control [in Russian]. STT, Tomsk, p 147

    Google Scholar 

  7. Gorizontov PD (1981) Blood system as the basis of bodily resistance and adaptation. Patol Fiziol Eksp Ter 2:55–63

    PubMed  Google Scholar 

  8. Gorizontov PD, Белоусова ОИ, Fedotova MI (1983) Stress and blood system [in Russian]. Meditsina, Moscow, p 240

    Google Scholar 

  9. Demin NN, Kogan AB, Moiseeva NI (1978) Neurophysiology and neurochemistry of sleep [in Russian]. Nauka, Leningrad, p 192

    Google Scholar 

  10. Dygai AM, Klimenko NA (1992) Inflammation and hemopoiesis [in Russian]. TGU, Tomsk, p 276

    Google Scholar 

  11. Dygai AM, Skurikhin EG, Provalova NV, Suslov NI (2002) Local regulation of proliferation and differentiation of hemopoietic precursors during experimental neurosis. Byull Eksp Biol Med 133(1):17–21

    Article  Google Scholar 

  12. Dygai AM, Skurikhin EG, Suslov NI et al (1998) Reactions of granulocytic hematopoietic stem cells during experimental neurosis-inducing situations. Byull Eksp Biol Med 126(12):628–631

    CAS  Google Scholar 

  13. Dygai AM, Suslov NI, Skurikhin EG, Churin AA (1997) Reactions of the erythropoietic progenitor cells in various types of neurotic actions. Byull Eksp Biol Med 123(2):158–161

    Article  CAS  Google Scholar 

  14. Klygul’ TA, Krivopalov VA (1966) A device for automatic registration of rat behavior for experimental evaluation of the effect of minor tranquilizers. FarmakolToksikol 2:241–244

    Google Scholar 

  15. Koval’zon VM (2003) Explorative activity, stress, and paradoxical sleep. Vestn Biol Psikhiatr 3:3–6

    Google Scholar 

  16. Pershina OV, Skurikhin EG, Stavrova LA et al (2004) Specific features of the erythroid hemopoietic stem in CBA/CaLac mice with neuroses demonstrating good and poor learning capacities. Byull Eksp Biol Med 138(11):499–505

    Google Scholar 

  17. Skurikhin EG (2004) Mechanisms of hemopoietic control during experimental neuroses: Abstract of Doct. Med. Sci. Dissertation [in Russian]. Tomsk, p 400

    Google Scholar 

  18. Skurikhin EG (1997) Reactions of blood system, behavioral abnormalities, and mechanisms of their development during experimental neurosis: Abstract of Cand. Med. Sci. Dissertation [in Russian]. Tomsk, p 211

    Google Scholar 

  19. Skurikhin EG, Dygai AM, Provalova NV et al (2005) Mechanisms of regulation of erythropoiesis during experimental neuroses. Byull Eksp Biol Med 139(5):495–501

    Article  Google Scholar 

  20. Skurikhin EG, Pershina OV, Provalova NV et al (2005) The mechanisms controlling hematopoietic granulocytic lineage in a conflict situation and during deprivation of paradoxical sleep. Byull Eksp Biol Med (Suppl 1):14–20

    Google Scholar 

  21. Skurikhin EG, Pershina OV, Suslov NI et al (2005) Role of Thy 1,2+ cells in the regulation of hemopoiesis during experimental neuroses. Byull Eksp Biol Med 139(6):608–612

    Article  Google Scholar 

  22. Skurikhin EG, Provalova NV (2000) The role of vegetative Ganglia in hemopoietic control under experimental neuroses. Problems of experimental and clinical pharmacology (Collected papers of Young Researches) [in Russian]. Tomsk, pp 37–38

    Google Scholar 

  23. Skurikhin EG, Suslov NI, Provalova NV et al (1999) The role of central adrenergic structures in hemopoietic control under experimental neuroses. Byull Eksp Biol Med 127(Suppl 1):7–11

    Google Scholar 

  24. Jouvet D, Vimont P, Delorme F, Jouvet M (1964) Study of selective deprivation of the paradoxal sleep phase in the cat. C R Seances Soc Biol Fil 158:756–759

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai & V. V. Zhdanov

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  1. A. M. Dygai
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  2. V. V. Zhdanov
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Dygai, A.M., Zhdanov, V.V. (2014). Disturbances in Hemopoietic Control During Neurotic Disorders. In: Theory of Hematopoiesis Control. SpringerBriefs in Cell Biology, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-08584-5_3

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