Abstract
Influenza type A viruses are classified into subtypes based on their two surface proteins, hemagglutinin (HA) and neuraminidase (NA). Our time series analysis on the strains of pandemic 2009 H1N1 collected from 2009 to 2013 demonstrated that the HA receptor binding preference of this virus in USA, Europe, and Asia has been the characteristic of swine H1N1 virus since 2009. However, its binding characteristics of seasonal human H1N1 and avian H1N1 both have been on steady rise with American strains having the sharpest surge in 2013. The first increase could enhance the viral transmission and replication in humans and the second boost its ability to cause infection deep in lungs, which might explain the recent human deaths caused by this virus in Texas in December 2013. We further explored the corresponding NA activity of this virus to reveal the functional interdependence between HA and NA during the evolution and adaptation of this virus from 2009 to 2013. To understand the real causality, the amino acid substitutions in HA and NA that actually produced the mutations were also identified.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Smith, G.J., Vijaykrishna, D., Bahl, J., et al.: Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459(7250), 1122–1125 (2009)
Childs, R.A., Palma, A.S., Wharton, S., et al.: Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray. Nat Biotechnol. 27, 797–799 (2009)
Gulati, U., Wu, W., Gulati, S., Kumari, K., Waner, J.L., Air, G.M.: Mismatched hemagglutinin and neuraminidase specificities in recent human H3N2 influenza viruses. Virology 339(1), 12–20 (2005)
Gerlach, T., Kühling, L., Uhlendorff, J., et al.: Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus. Vaccine 30(51), 7348–7352 (2012)
Hu, W.: Receptor binding specificity and sequence comparison of a novel avian-origin H7N9 virus in China. Journal of Biomedical Science and Engineering 6(5), 533–542 (2013)
Hu, W.: Mutations in Hemagglutinin of a Novel Avian-Origin H7N9 Virus That Are Critical for Receptor Binding Specificity. Tsinghua Science and Technology 18(5), 522–529 (2013)
Veljkovic, V., Niman, H.L., Glisic, S., et al.: Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptor. BMC Structural Biology 9, 62 (2009)
Veljkovic, V., Veljkovic, N., Muller, C.P., et al.: Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control. BMC Struct. Biol. 7, 9–21 (2009)
Breiman, L.: Random forests. Machine Learning 45, 5–32 (2001)
Belser, J.A., Jayaraman, A., Raman, R., et al.: Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus. PLoS ONEÂ 6(9), e25091 (2011)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Hu, W. (2014). Functional Interplay between Hemagglutinin and Neuraminidase of Pandemic 2009 H1N1 from the Perspective of Virus Evolution. In: Basu, M., Pan, Y., Wang, J. (eds) Bioinformatics Research and Applications. ISBRA 2014. Lecture Notes in Computer Science(), vol 8492. Springer, Cham. https://doi.org/10.1007/978-3-319-08171-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-319-08171-7_4
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08170-0
Online ISBN: 978-3-319-08171-7
eBook Packages: Computer ScienceComputer Science (R0)