Visualizing and Identifying the DNA Methylation Markers in Breast Cancer Tumor Subtypes

  • Islam Ibrahim Amin
  • Aboul Ella Hassanien
  • Hesham A. Hefny
  • Samar K. Kassim
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 303)

Abstract

DNA methylation is an epigenetic mechanism that cells use to control gene expression. DNA methylation has become one of the hottest topics in cancer research, especially for abnormally hypermethylated tumor suppressor genes or hypomethylaed oncogenes research. The analysis of DNA methylation data determines the differential hypermethlated or hypomethylated genes that are candidate to be cancer biomarkers. Visualization the DNA methylation status may lead to discover new relationships between hypomethylated and hypermethylated genes, therefore this paper applied a mathematical modelling theory called formal concept analysis for visualizing DNA methylation status.

Keywords

DNA methylation Epigenetic hypomethylated genes hypermethlated genes Formal concept analysis 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Islam Ibrahim Amin
    • 1
    • 4
  • Aboul Ella Hassanien
    • 2
    • 4
  • Hesham A. Hefny
    • 1
  • Samar K. Kassim
    • 3
  1. 1.Institute of Statistical Studies and ResearchesCairo UniversityCairoEgypt
  2. 2.Faculty of Computers and InformationCairo UniversityCairoEgypt
  3. 3.Faculty of MedicineAin Shams UniversityCairoEgypt
  4. 4.Scientific Research Group in Egypt (SRGE)CairoEgypt

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