Abstract
In this pilot study we investigated whether a transcortical pathway mediates the short-latency responses elicited in the contralateral gastrocnemius lateralis (cGL) by ipsilateral posterior tibial nerve (iPTN) stimulation. For this purpose, single pulse sub-threshold (90% active motor threshold) transcranial magnetic stimulation (subTMS) was applied in combination with iPTN stimulation at several interstimulus intervals (ISI) while the subjects (n=6) walked. SubTMS has been shown to reduce cortical output to the target muscle, inducing a suppression in the EMG signal of the voluntary activated muscle. While no differences were observed for the first component to the response, a considerable depression of the second part, referred to as long-latency component (LLC) was observed when the subTMS was timed such that the induced suppression would coincide with this component. These results strongly suggest the cortical control of the LLC in the cGL response. This allows for an enhanced flexibility during unexpected perturbations, ensuring that the appropriate output is produced in accord with the functional demand.
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References
Stubbs, P.W., Mrachacz-Kersting, N.: Short latency crossed inhibitory responses in the human soleus muscle. J. Neurophysiol. (102), 3596–3605 (2009)
Stevenson, A.J., Geertsen, S.S., Andersen, J.B., Sinkjaer, T., Nielsen, J.B., Mrachacz-Kersting, N.: Interlimb communication to the knee flexors during walking in humans. J. Physiol. 591(Pt. 19), 4921–4935 (2013)
Gervasio, S., Farina, D., Sinkjaer, T., Mrachacz-Kersting, N.: Crossed reflex reversal during human locomotion. J. Neurophysiol. 109(9), 2335–2344 (2013)
Stubbs, P.W., Nielsen, J.F., Sinkjaer, T., Mrachacz-Kersting, N.: Phase modulation of the short-latency crossed spinal response in the human soleus muscle. J. Neurophysiol. 105(2), 503–511 (2011)
Jankowska, E.: Spinal interneuronal networks in the cat: Elementary components. Brain Research Reviews 57(1), 46–55 (2008)
Petersen, N.T., Butler, J.E., Marchand-Pauvert, V., Fisher, R., Ledebt, A., Pyndt, H.S., Hansen, N.L., Nielsen, J.B.: Suppression of EMG activity by transcranial magnetic stimulation in human subjects during walking. J. Physiol. 537(Pt. 2), 651–656 (2001)
Schubert, M., Curt, A., Jensen, L., Dietz, V.: Corticospinal input in human gait: modulation of magentically evoked motor responses. Exp. Brain Res. 115, 234–246 (1997)
van de Wassenberg, W.J.G., Kruizinga, W.J., van der Hoeven, J.H., Leenders, K.L., Maurits, N.M.: Multichannel recording of tibial-nerve somatosensory evoked potentials. Neurophysiologie Clinique/Clinical Neurophysiology 38(5), 277–288 (2008)
Kurusu, K., Kitamura, J.: Long-latency reflexes in contracted hand and foot muscles and their relations to somatosensory evoked potentials and transcranial magnetic stimulation of the motor cortex. Clin. Neurophysiol. 110, 2014–2019 (1999)
Nielsen, J., Petersen, N., Fedirchuck, B.: Evidence suggesting a transcortical pathway from cutaneous foot afferents to tibialis anterior motoneurones in man. J. Physiol (Lond.) 501(2), 473–484 (1997)
Lazzaro, V.D., Restuccia, D., Oliviero, A., Profice, P., Ferrara, L., Insola, A., Mazzone, P., Tonali, P., Rothwell, J.C.: Magnetic transcranial stimulation at intensities below active motor threshold activates intracortical inhibitory circuits. Experimental Brain Research 119(2), 265–268 (1998)
van Doornik, J., Masakado, Y., Sinkjaer, T., Nielsen, J.B.: The suppression of the long-latency stretch reflex in the human tibialis anterior muscle by transcranial magnetic stimulation. Experimental Brain Research 157(3), 403–406 (2004)
Mrachacz-Kersting, N., Grey, M.J., Sinkjaer, T.: Evidence for a supraspinal contribution to the human quadriceps long-latency stretch reflex. Experimental Brain Research 168(4), 529–540 (2006)
Jankowska, E., Hammar, I.: Interactions between spinal interneurons and ventral spinocerebellar tract neurons. J. Physiol. 591(Pt. 22), 5445–5451 (2013)
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Mrachacz-Kersting, N., Gervasio, S., Farina, D., Sinkjær, T. (2014). Cortical Contribution to Crossed Reflexes in Walking Humans. In: Jensen, W., Andersen, O., Akay, M. (eds) Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation. Biosystems & Biorobotics, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-08072-7_84
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DOI: https://doi.org/10.1007/978-3-319-08072-7_84
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08071-0
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