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Translational science

  • Krishnansu Tewari
  • Bradley Monk
Chapter

Abstract

Approximately 150 years ago, the concept of cancer ‘stem cell’ populations was introduced [1]. As certain subpopulations of cancer cells have inherited normal stem cell properties including capacity for self-renewal, ability to differentiate, activate anti-apoptotic pathways, and metastasize, cancer stem cell response correlates directly with survival [2–4]. Taken further, the relative amount of chemotherapy-induced neutropenia (i.e., differentiated cell response) would be expected to correlate with survival (i.e., cancer stem cell response). It has been postulated that with increasing severity of neutropenia, a greater fractional kill of cancer stem cells occurs, potentially improving survival. Further work is required to determine whether the severity (rather than just the occurrence) of neutropenia correlates with clinical outcome.

Keywords

Vascular Endothelial Growth Factor Ovarian Cancer Cancer Stem Cell National Comprehensive Cancer Network Serous Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Krishnansu Tewari
    • 1
  • Bradley Monk
    • 2
  1. 1.University of California, Irvine Medical Gynecologic Oncology GroupOrangeUSA
  2. 2.St Joseph’s Hospital and Medical Center Division of Gynecologic OncologyPhoenixUSA

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