Skip to main content

Treatment-Related Diseases

  • Chapter
  • First Online:
Colitis

Abstract

A variety of conditions may develop as an adverse event or within the context of specific types of treatment such as radiation treatment for cancer, some types of surgery, and stem cell or solid organ transplantation. While the microscopic aspect of a colon biopsy may suggest the diagnosis, clinical information is extremely useful because other conditions may mimic certain patterns, or the lesions secondary to the treatment may not be entirely specific. Surgery is sometimes performed in order to divert the fecal stream. Indications for such a procedure can be variable and include, among others, Crohn’s disease, collagenous colitis, and acute abdominal conditions such as obstruction and perforation. The interpretation of the lesions can be difficult depending on whether the patient has established inflammatory bowel disease before the procedure or not. In patients with IBD, the differential diagnosis between diversion colitis and IBD may be difficult and rely partially on the study of samples of the non-diverted segment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Willett CG, Ooi CJ, Zietman AL, et al. Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms. Int J Radiat Oncol Biol Phys. 2000;46:995–8.

    Article  CAS  PubMed  Google Scholar 

  2. MacNaughton WK. New insights into the pathogenesis of radiation-induced intestinal dysfunction. Aliment Pharmacol Ther. 2000;14:523–8.

    Article  CAS  PubMed  Google Scholar 

  3. Beck PL, Wong JF, Li Y, et al. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology. 2004;126:796–808.

    Article  CAS  PubMed  Google Scholar 

  4. Duncan M, Grant G. Oral and intestinal mucositis – causes and possible treatments. Aliment Pharmacol Ther. 2003;18:853–74.

    Article  CAS  PubMed  Google Scholar 

  5. Leupin N, Curschmann J, Kranzbühler H, et al. Acute radiation colitis in patients treated with short-term preoperative radiotherapy for rectal cancer. Am J Surg Pathol. 2002;26:498–504.

    Article  PubMed  Google Scholar 

  6. Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13–22.

    Article  PubMed  Google Scholar 

  7. Glotzer DJ, Glick ME, Goldman H. Proctitis and colitis following diversion of the fecal stream. Gastroenterology. 1981;80:438–41.

    CAS  PubMed  Google Scholar 

  8. Komorowski RA. Histologic spectrum of diversion colitis. Am J Surg Pathol. 1990;14:548–54.

    Article  CAS  PubMed  Google Scholar 

  9. Whitehead R. Colitis: problems in definition and diagnosis. Virchows Archiv Pathol Anat. 1990;47:187–90.

    Article  Google Scholar 

  10. Toolenaar TA, Freundt I, Huikeshoven FJ, et al. The occurrence of diversion colitis in patients with a sigmoid neovagina. Hum Pathol. 1993;24:846–9.

    Article  CAS  PubMed  Google Scholar 

  11. Geraghty JM, Talbot IC. Diversion colitis: histological features in the colon and rectum after defunctioning colostomy. Gut. 1991;32:1020–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Roe AM, Warren BF, Brodribb AJM, et al. Diversion colitis and involution of the defunctioned anorectum. Gut. 1993;34:382–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Antonioli DA. Pediatric inflammatory bowel disease. Pediatr Devel Pathol. 2005;8:2–19.

    Article  Google Scholar 

  14. Yantiss RK, Odze RD. Diagnostic difficulties in inflammatory bowel disease pathology. Histopathology. 2006;48:116–32.

    Article  CAS  PubMed  Google Scholar 

  15. Epstein RJ, McDonald GB, Sale GE, et al. The diagnostic accuracy of the rectal biopsy in acute graft-versus-host-disease: a prospective study of thirteen patients. Gastroenterology. 1980;78:764–71.

    CAS  PubMed  Google Scholar 

  16. Snover DC, Weisdorf SA, Vercellotti GM, et al. A histopathologic study of gastric and small intestinal Graft-versus-host disease following allogeneic bone marrow transplantation. Hum Pathol. 1985;16:387–92.

    Article  CAS  PubMed  Google Scholar 

  17. Shulman HM, Kleiner D, Lee SJ, et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant. 2006;12:31–47.

    Article  PubMed  Google Scholar 

  18. Snover DC. Mucosal damage simulating acute graft-versus-host reaction in cytomegalovirus colitis. Transplantation. 1985;39:670–1.

    Article  Google Scholar 

  19. Shimoni A, Rimon U, Hertz M, et al. CT in the clinical and prognostic evaluation of acute graft versus host disease of the gastrointestinal tract. Br J Radiol. 2012;85:e416–23.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Herrera AF, Soriano G, Bellizzi AM, et al. Cord colitis syndrome in cord-blood stem-cell transplantation. N Engl J Med. 2011;365:815–24.

    Article  CAS  PubMed  Google Scholar 

  21. Gupta NK, Masia R. Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract. Am J Surg Pathol. 2013;37:1109–13.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Wörns MA, Lohse AW, Neurath MF, et al. Five cases of de novo inflammatory bowel disease after orthotopic liver transplantation. Am J Gastroenterol. 2006;101:1931–7.

    Article  PubMed  Google Scholar 

  23. Vu F, Maillard M, Pascual M, et al. De novo inflammatory bowel disease after liver transplantation: description of four new cases and a review of the literature. Gastroenterol Clin Biol. 2006;30:1096–101.

    Article  PubMed  Google Scholar 

  24. Geboes K. Crohn’s disease and solid organ transplantation. Gastroenterol Hepatol. 2008;4:879–80.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Karel Geboes MD, PhD, AGAF .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Geboes, K., Leo, M., Gerosa, C., Van Eyken, P. (2014). Treatment-Related Diseases. In: Geboes, K., Nemolato, S., Leo, M., Faa, G. (eds) Colitis. Springer, Cham. https://doi.org/10.1007/978-3-319-08028-4_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-08028-4_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08027-7

  • Online ISBN: 978-3-319-08028-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics