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Histone H3 Phosphorylation in Plants and Other Organisms

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Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications

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Abstract

Post-translational histone modifications, such as methylation and phosphorylation, play an important role in determining chromatin states associated with gene activation or repression. Histone H3 phosphorylation in particular has been linked to a variety of cellular processes during the cell cycle. H3 phosphorylation is involved in chromosome condensation and segregation during mitosis and meiosis in plants and animals. During interphase, H3 phosphorylation has been implicated in transcriptional regulation, DNA replication and apoptosis. Phosphorylation also occurs in the histone variants, H3.3 and CENH3, during cell division. The diverse and sometimes contrasting processes in which H3 phosphorylation participates have made difficult to completely understand its function. In addition, functional differences on H3 phosphorylation have been observed in diverse organisms despite the conservation of the modified residue. Here we discuss the most recent findings about the roles of histone H3 phosphorylation, the proteins involved in phosphorylating particular residues and the mechanisms by which this modification results in a particular gene expression state. The differences and similarities between plants and other model systems are emphasized.

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Acknowledgments

J.A.C.-M. is supported by a Young Investigator grant from the São Paulo Research Foundation (FAPESP 2011/50483-2). I.M. is recipient of a FAPESP fellowship (2013/01484-1). We apologize to all researchers whose contributions could not be cited due to space limitations.

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  1. Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, 05508-000, Brazil

    Izabel Moraes & Juan Armando Casas-Mollano

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  1. Izabel Moraes
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Correspondence to Juan Armando Casas-Mollano .

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Moraes, I., Casas-Mollano, J.A. (2014). Histone H3 Phosphorylation in Plants and Other Organisms. In: Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-07971-4_4

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