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Fc Receptors pp 95–110Cite as

Calcium Channels in Fc Receptor Signaling

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 382))

Abstract

The calcium ion (Ca2+) is the main common second messenger involved in signaling transduction subsequent to immunoreceptor activation. Its rapid intracellular elevation induces multiple cellular responses, such as secretion, proliferation, mobility, and gene transcription. Intracellular levels of Ca2+ need to reach a specific threshold to efficiently transduce the signal to activate transcription factors through the recruitment of Ca2+-binding molecules. However, since Ca2+ cannot be metabolized, its intracellular concentration is tightly regulated to avoid the induction of programmed cell death. This highly controlled regulation of Ca2+ homeostasis has recently been clarified by the uncovering of new ion channels. The regulation of these channels allows the role of Ca2+ in Fc receptor transduction pathways to be more precisely defined.

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Authors and Affiliations

  1. Inserm U1149, Bichat Medical School, Paris, France

    Tarik Attout & Pierre Launay

  2. Cambridge Institute for Medical Research, University Cambridge, Cambridge, UK

    Andres Floto

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  1. Tarik Attout
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  2. Andres Floto
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  3. Pierre Launay
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Correspondence to Pierre Launay .

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Editors and Affiliations

  1. Institut Pasteur, Paris, France

    Marc Daeron

  2. Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany

    Falk Nimmerjahn

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Attout, T., Floto, A., Launay, P. (2014). Calcium Channels in Fc Receptor Signaling. In: Daeron, M., Nimmerjahn, F. (eds) Fc Receptors. Current Topics in Microbiology and Immunology, vol 382. Springer, Cham. https://doi.org/10.1007/978-3-319-07911-0_5

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