The Quartz Crystal Microbalance in Soft Matter Research

Part of the series Soft and Biological Matter pp 191-204


Gravimetric Sensing

  • Diethelm JohannsmannAffiliated withInstitute of Physical Chemistry, Clausthal University of Technology Email author 

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The advanced QCMs provide information beyond gravimetry, but that is not to say that gravimetry was obsolete. Gravimetry is based on the Sauerbrey equation, derived in this chapter from the small load approximation. Strategies are discussed to improve the limit of detection. At least as important as sensitivity is specificity, meaning the ability to distinguish between different analytes. Specificity is achieved with receptor layers.