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Estimation of Missing Values in SNP Array

  • Przemyslaw Podsiadly
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8482)

Abstract

DNA microarray usage in genetics is rapidly proliferating, generating huge amount of data. It is estimated that around 5-20% of measurements do not succeed, leading to missing values in the data destined for further analysis. Missing values in further microarray analysis lead to low reliability, therefore there is a need for effective and efficient methods of missing values estimation.

This report presents a method for estimating missing values in SNP Microarrays using k-Nearest Neighbors among similar individuals. Usage of preliminary imputation is proposed and discussed. It is shown that introduction of multiple passes of kNN improves quality of missing value estimation.

Keywords

microarray bioinformatics SNP array missing values 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Przemyslaw Podsiadly
    • 1
  1. 1.Institute of Computer ScienceWarsaw University of TechnologyWarsawPoland

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