Colombo J, Shoemaker WC. Non-invasive autonomic nervous system monitoring in critical care. In: Shoemaker WC et al., editors. Procedures and monitoring for the critically ill. Philadelphia: W.B. Saunders Co; 2000. p. 211–24.
Colombo J, Shoemaker WC, Belzberg H, Hatzakis G, Fathizadeh P, Demetriades D. Noninvasive monitoring of the autonomic nervous system and hemodynamics of patients with blunt and penetrating trauma. J Trauma. 2008;65(6):1364–73.
Zaglaniczny K, Shoemaker WC, Gorguze DS, Woo C, Colombo J, Blood CG. Examination of real-time heart rate variability during laparoscopic cholecystectomies and radical surgeries. Navy Report No. 00-47, NHRC, San Diego; 2000
Fathizadeh P, Shoemaker WC, Woo CCJ, Colombo J. Autonomic activity in trauma patients based on variability of heart rate and respiratory rate. Crit Care Med. 2004;32(5):1300–5.
Akselrod S, Gordon S, Ubel FA, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuations: a quantitative probe of beat-to- beat cardiovascular control. Science. 1981;213:213–20.
Akselrod S, Gordon D, Madwed JB, Snidman NC, Shannon DC, Cohen RJ. Hemodynamic regulation: investigation by spectra analysis. Am J Physiol. 1985;249:H867–75.
Akselrod S, Eliash S, Oz O, Cohen S. Hemodynamic regulation in SHR: investigation by spectral analysis. Am J Physiol. 1987;253:H176–83.
Akselrod S. Spectral analysis of fluctuations in cardiovascular parameters: a quantitative tool for the investigation of autonomic control. Trends Pharmacol Sci. 1988;9:6–9.
Boyd G, Stout D, Aultman M, Wyatt K, Vetter T. Are there reliable clinical predictors of cardiac autonomic neuropathy in diabetic patients? American Society of Anesthesiologists, annual meeting, San Diego, 16–20 Oct 2010.
Boyd G, Stout D, Morris R, Witherspoon CD, Vetter T, et al. Prevalence and severity of autonomic dysfunction in diabetic patients presenting for retinal surgery American Society of Anesthesiologists, Annual Meeting, San Diego, 16–20 Oct 2010.
Hanss R, Renner J, Ilies C, Moikow L, Buell O, Steinfath M, Scholz J, Bein B. Does heart rate variability predict hypotension and bradycardia after induction of general anaesthesia in high risk cardiovascular patients? Anaesthesia. 2008;63:129–35.
Latson TW, Ashmore TH, Reinhart DJ, Klein KW, Giesecke AH. Autonomic reflex dysfunction in patients presenting for elective surgery is associated with hypotension after anesthesia induction. Anesthesiology. 1994;80:326–37.
Burgos LG, Ebert TJ, Asiddao C, Turner LA, Pattison CZ, Wang-Cheng R, Kampine JP. Increased intraoperative cardiovascular morbidity in diabetics with autonomic neuropathy. Anesthesiology. 1989;70:591–7.
Knuttgen D, Buttner-Belz U, Gernot A, Doehn M. Unstable blood pressure during anesthesia in diabetic patients with autonomic neuropathy. Anasth Intensivther Notfallmed. 1990;25:256–62.
Huang CJ, Kuok CH, Kuo TB, Hsu YW, Tsai PS. Pre-operative measurement of heart rate variability predicts hypotension during general anesthesia. Acta Anaesthesiol Scand. 2006;50:542–8.
Ciccarelli LL, Ford CM, Tsueda K. Autonomic neuropathy in a diabetic patient with renal failure. Anesthesiology. 1986;64:283–7.
Amour J, Kersten JR. Diabetic cardiomyopathy and anesthesia: bench to bedside. Anesthesiology. 2008;108:524–30.
Kahn JK, Sisson JC, Vinik AI. Prediction of sudden cardiac death in diabetic autonomic neuropathy. J Nucl Med. 1988;29:1605–6.
Debono M, Cachia E. The impact of cardiovascular autonomic neuropathy in diabetes: is it associated with left ventricular dysfunction? Auton Neurosci. 2007;132:1–7.
Pop-Busui R, Kirkwood I, Schmid H, Marinescu V, Schroeder J, Larkin D, Yamada E, Raffel DM, Stevens MJ. Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. J Am Coll Cardiol. 2004;44:2368–74.
Valensi P, Sachs RN, Harfouche B, Lormeau B, Paries J, Cosson E, Paycha F, Leutenegger M, Attali JR. Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia. Diabetes Care. 2001;24:339–43.
Rauch U, Ziegler D, Piolot R, Schwippert B, Benthake H, Schultheiss HP, Tschoepe D. Platelet activation in diabetic cardiovascular autonomic neuropathy. Diabet Med. 1999;16:848–52.
Fleisher LA. Heart rate variability as an assessment of cardiovascular status. J Cardiothorac Vasc Anesth. 1996;10(5):659–71.
Schubert A, Palazzolo JA, Brum JM, Ribeiro MP, Tan M. Heart rate, heart rate variability, and blood pressure during perioperative stressor events in abdominal surgery. J Clin Anesth. 1997;9(1):52–60.
Schmid H, Schaan B, Cecconello F, Maestri T, Neumann C. Proliferative diabetic retinopathy is related to cardiovascular autonomic neuropathy in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1995;29:163–8.
Klein R, Moss SE, Klein BE, DeMets DL. Relation of ocular and systemic factors to survival in diabetes. Arch Intern Med. 1989;149:266–72.
Knatterud GL. Mortality experience in the diabetic retinopathy study. Isr J Med Sci. 1983;19:424–8.
Borch-Johnsen K, Kreiner S. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. Br Med J (Clin Res Ed). 1987;294:1651–4.
Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984;310:356–60.
Uchio E, Inamura M, Ohno S, Taguchi H, Saeki K. Survival rate after vitreous surgery in patients with diabetic retinopathy. Ophthalmologica. 1993;206:83–8.
Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg surveys S2 and S3. Diabetes Care. 2008;31:464–9.
Nishimura. Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in diabetic hemodialysis patients. Nephrol Dial Transplant. 2004;19:2532–8.
Lefrandt JD, Smit AJ, Zeebregts CJ, Gans RO, Hoogenberg KH. Autonomic dysfunction in diabetes: a consequence of cardiovascular damage. Curr Diabetes Rev. 2010;6(6):348–58.
Gollamudi SR, Smiddy WE, Schachat AP, Michels RG, Vitale S. Long-term survival rate after vitreous surgery for complications of diabetic retinopathy. Ophthalmology. 1991;98:18–22.
Schmitz A, Vaeth M. Microalbuminuria: a major risk factor in non-insulin-dependent diabetes. A 10-year follow-up study of 503 patients. Diabet Med. 1988;5:126–34.
Messent JW, Elliott TG, Hill RD, Jarrett RJ, Keen H, Viberti GC. Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty-three year follow-up study. Kidney Int. 1992;41:836–9.
Nishinura M, Hashimoto T, Kobayashi H, Fukuda T, Okino K, Yamamoto N, Nakamura N, Yoshikawa T, Takahashi H, Ono T. Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in diabetic haemodialysis patients. Nephrol Dial Transplant. 2004;19(10):2532–8.
Umetani K, Singer DH, McCraty R, Atkinson M. Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol. 1998;31(3):593–601.
Lipsitz LA, Mietus J, Moody GB, Goldberger AL. Spectral characteristics of heart rate variability before and during postural tilt. Relations to aging and risk of syncope. Circulation. 1990;81:1803–10.
Collins K. The autonomic nervous system in old age. Rev Clin Gerontol. 1991;1:337–45.
Crasset V, Mezzetti S, Antoine M, Linkowski P, Degaute JP, van de Borne P. Effects of aging and cardiac denervation on heart rate variability during sleep. Circulation. 2001;103:84–8.
Smith JJ, Hughes CV, Ptacin MJ, Barney JA, Tristani FE, Ebert TJ. The effect of age on hemodynamic response to graded postural stress in normal men. J Gerontol. 1987;42:406–11.
Shannon DC, Carley DW, Benson H. Aging of modulation of heart rate. Am J Physiol. 1987;253:H874–7.
Ebert TJ, Morgan BJ, Barney JA, Denahan T, Smith JJ. Effects of aging on baroreflex regulation of sympathetic activity in humans. Am J Physiol. 1992;263:H798–803.
Akinola A, Bleasdale-Barr K, Everall L, Mathias CJ. Investigation of autonomic disorders: appendix I. In: Mathias CJ, Bannister R, editors. Autonomic failure: a textbook of clinical disorders of the autonomic nervous system. London: Oxford Medical Publications; 1999.
Brancati FL, Kao WH, Folsom AR, Watson RL, Szklo M. Incident type 2 diabetes mellitus in African American and white adults: the atherosclerosis risk in communities study. JAMA. 2000;283:2253–9.
Parmer RJ, Cervenka JH, Stone RA, O’Connor DT. Autonomic function in hypertension. Are there racial differences? Circulation. 1990;81:1305–11.
Karter AJ, Ferrara A, Liu JY, Moffet HH, Ackerson LM, Selby JV. Ethnic disparities in diabetic complications in an insured population. JAMA. 2002;287:2519–27.
Morita H, Wu J, Zipes DP. The QT syndromes: long and short. Lancet. 2008;372:750–63.
Gill GV, Woodward A, Casson IF, Weston PJ. Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes–the ‘dead in bed’ syndrome revisited. Diabetologia. 2009;52:42–5.
Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MC, Stricker BH, Witteman JC. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006;47:362–7.
Ewing DJ, Boland O, Neilson JM, Cho CG, Clarke BF. Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia. 1991;34:182–5.
Veglio M, Borra M, Stevens LK, Fuller JH, Perin PC. The relation between QTc interval prolongation and diabetic complications. The EURODIAB IDDM Complication Study Group. Diabetologia. 1999;42:68–75.
Sivieri R, Veglio M, Chinaglia A, Scaglione P, Cavallo-Perin P. Prevalence of QT prolongation in a type 1 diabetic population and its association with autonomic neuropathy. The Neuropathy Study Group of the Italian Society for the Study of Diabetes. Diabet Med. 1993;10:920–4.
Kahn JK, Sisson JC, Vinik AI. QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. J Clin Endocrinol Metab. 1987;64:751–4.
Sawicki PT, Dahne R, Bender R, Berger M. Prolonged QT interval as a predictor of mortality in diabetic nephropathy. Diabetologia. 1996;39:77–81.
Lykke JA, Tarnow L, Parving HH, Hilsted J. A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes. Scand J Clin Lab Invest. 2008;68(7):654–9.
Ziegler D, Zentai CP, Perz S, Rathmann W, Haastert B, Doring A, Meisinger C. Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA/KORA Augsburg cohort study. Diabetes Care. 2008;31:556–61.
Lacigova S, Safranek P, Cechurova D, Krcma M, Visek J, Jankovec Z, Zourek M, Haladova I, Rusavy Z. Could we predict asymptomatic cardiovascular autonomic neuropathy in type 1 diabetic patients attending out-patients clinics? Wien Klin Wochenschr. 2007;119:303–8.
Bullinga JR, Alharethi R, Schram MS, Bristow MR, Gilbert EM. Changes in heart rate variability are correlated to hemodynamic improvement with chronic CARVEDILOL therapy in heart failure. J Card Fail. 2005;11(9):693–9.
Pousset F, Copie X, Lechat P, Jaillon P, Boissel JP, Hetzel M, Fillette F, Remme W, Guize L, Le Heuzey JY. Effects of bisoprolol on heart rate variability in heart failure. Am J Cardiol. 1996;77:612–7.
Burger AJ, Kamalesh M. Effect of beta-adrenergic blocker therapy on the circadian rhythm of heart rate variability in patients with chronic stable angina pectoris. Am J Cardiol. 1999;83:596–8, A8.
Ziegler D. Cardiovascular autonomic neuropathy: clinical manifestations and measurement. Diabetes Rev. 1999;7:342–57.
Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the beta-blocker heart attack trial. Am J Cardiol. 2003;91:137–42.
Vinik A, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115:387–97.
Didangelos TP, Arsos GA, Karamitsos DT, Athyros VG, Georga SD, Karatzas ND. Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. J Diabetes Complications. 2006;20:1–7.
Van Cauwenberge I, Philips JC, Scheen AJ. Anaesthetic risk related to cardiac autonomic neuropathy in diabetic patients. Rev Med Liege. 2008;63:488–93.
Filipovic M, Jeger R, Probst C, Girard T, Pfisterer M, Gurke L, Skarvan K, Seeberger MD. Heart rate variability and cardiac troponin I are incremental and independent predictors of one-year all-cause mortality after major noncardiac surgery in patients at risk of coronary artery disease. J Am Coll Cardiol. 2003;42:1767–76.
Laitio T, Jalonen J, Kuusela T, Scheinin H. The role of heart rate variability in risk stratification for adverse postoperative cardiac events. Anesth Analg. 2007;105:1548–60.
Low PA, Benrud-Larson LM, Sletten DM, Opfer-Gehrking TL, Weigand SD, O’Brien PC, Suarez GA, Dyck PJ. Autonomic symptoms and diabetic neuropathy: a population-based study. Diabetes Care. 2004;27:2942–7.
Astrup AS, Tarnow L, Rossing P, Hansen BV, Hilsted J, Parving HH. Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Diabetes Care. 2006;29:334–9.
Hanss R, Block D, Bauer M, Ilies C, Magheli A, Schildberg-Schroth H, Renner J, Scholz J, Bein B. Use of heart rate variability analysis to determine the risk of cardiac ischaemia in high-risk patients undergoing general anaesthesia. Anaesthesia. 2008;63:1167–73.
Monmeneu JV, Chorro FJ, Bodi V, Sanchis J, Llacer A, Garcia-Civera R, Ruiz R, Sanjuan R, Burguera M, Lopez-Merino V. Relationships between heart rate variability, functional capacity, and left ventricular function following myocardial infarction: an evaluation after one week and six months. Clin Cardiol. 2001;24:313–20.
Rich MW, Saini JS, Kleiger RE, Carney RM, teVelde A, Freedland KE. Correlation of heart rate variability with clinical and angiographic variables and late mortality after coronary angiography. Am J Cardiol. 1988;62:714–7.
Hayano J, Sakakibara Y, Yamada M, Ohte N, Fujinami T, Yokoyama K, Watanabe Y, Takata K. Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity. Circulation. 1990;81:1217–24.
Little JP. Consistency of ASA grading. Anaesthesia. 1995;50:658–9.
Owens WD, Felts JA, Spitznagel Jr EL. ASA physical status classifications: a study of consistency of ratings. Anesthesiology. 1978;49:239–43.
Inui K, Sannan H, Ota H, Uji Y, Nomura S, Kaige H, Kitayama I, Nomura J. EEG findings in diabetic patients with and without retinopathy. Acta Neurol Scand. 1998;97:107–9.
Manschot SM, Biessels GJ, de Valk H, Algra A, Rutten GE, van der Grond J, Kappelle LJ. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia. 2007;50:2388–97.
Petursson P, Gudbjornsdottir S, Aune S, Svensson L, Oddby E, Sjoland H, Herlitz J. Patients with a history of diabetes have a lower survival rate after in-hospital cardiac arrest. Resuscitation. 2008;76:37–42.
Monk TG, Saini V, Weldon BC, Sigl JC. Anesthetic management and one-year mortality after noncardiac surgery. Anesth Analg. 2005;100:4–10.
Kheterpal S, O’Reilly M, Englesbe MJ, Rosenberg AL, Shanks AM, Zhang L, Rothman ED, Campbell DA, Tremper KK. Preoperative and intraoperative predictors of cardiac adverse events after general, vascular, and urological surgery. Anesthesiology. 2009;110:58–66.
Keyl C, Lemberger P, Palitzsch KD, Hochmuth K, Liebold A, Hobbhahn J. Cardiovascular autonomic dysfunction and hemodynamic response to anesthetic induction in patients with coronary artery disease and diabetes mellitus. Anesth Analg. 1999;88:985–91.
Deutschman CS, Harris AP, Fleisher LA. Changes in heart rate variability under propofol anesthesia: a possible explanation for propofol-induced bradycardia. Anesth Analg. 1994;79:373–7.
Tramer MR, Moore RA, McQuay HJ. Propofol and bradycardia: causation, frequency and severity. Br J Anaesth. 1997;78:642–51.
Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care. 2004;27:1954–61.
Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009;301:1547–55.
Lee KH, Jang HJ, Kim YH, Lee EJ, Choe YS, Choi Y, Lee MG, Lee SH, Kim BT. Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease. Am J Cardiol. 2003;92:1458–61.
Schubert A. Why is power spectral heart rate analysis of interest to the anesthesiologist. A publication furnished by Cleveland Clinic. 1990.
Estafanous FG, Brum JM, Ribeiro MP, Estafanous M, Starr N, Ferrario C. Analysis of heart rate variability to assess hemodynamic alterations following induction of anesthesia. J Cardiothorac Vasc Anesth. 1992;6(6):647–57.
Young LH, Wackers FJT, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE, the DIAD Investigators. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009;301(15):1547–55.
Maser RE, Lenhard MJ. Review: cardiovascular autonomic neuropathy due to diabetes mellitus: clinical manifestations, consequences, and treatment. J Clin Endocrinol Metab. 2005;90:5896–903.
Huang CJ, Kuok CH, Kuo TBJ, Hsu YW, Tsai PS. Pre-operative measurement of heart rate variability predicts hypotension during general anesthesia. Acta Anaesth Scan. 2006;50:542–8.
Garrard CS, Kontoyannis DA, Piepoli M. Spectral analysis of heart rate variability in the sepsis syndrome. Clin Auton Res. 1993;3:5–13.
Brum JM, et al. Power spectrum of heart rate variability. Cleveland Clinic Foundation Report, Cleveland, OH; 1991.
Butler R, MacDonald TM, Struthers AD, Norris AD. Eur Heart L. 1998;19:1617–27.
Genovely H, Pfeifer MA. RR-variation; the autonomic test of choice in diabetes. Diabetes Metabol Rev. 1988;4:255–71.
Casolo G, Balli E, Taddei T, et al. Decreased spontaneous heart rate variability in congestive heart failure. Am J Cardiol. 1989;64:1162–7.
Casolo G. Heart rate variability in patients with heart failure. In: Malik M, Gamm AJ, editors. Heart rate variability. Armonk: Futura; 1995. p. 449–65.
Stenfenelli T, Bergler-Klein J, Globits S, et al. Heart rate behavior at different stages of heart failure. Eur Heart J. 1992;13:902–7.
Magdid NM, et al. Diminished heart rate variability in patients with sudden cardiac death. Circulation. 1985;72(Suppl III): iii-241.
Pagani M, Malfatto G, Peirini S, et al. Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy. J Auton Nerv Syst. 1988;23:143–53.
Schumer MP, Joyner SA, Pfeifer MA. Cardiovascular autonomic neuropathy testing in patients with diabetes. Diabetes Spectr. 1998;11:227–31.
Karpen J, Ortiz R, Shoemaker WC. Parasympathetic and sympathetic monitoring in pain management. Online publication at Pain.com; 14 Jan 2010.
Cong X, Ludington-Hoe SM, McCain G, Fu P. Kangaroo Care modifies preterm infant heart rate variability in response to heel stick pain: pilot study. Early Hum Dev. 2009;85(9):561–7.
Hon EH, Lee ST. Electronic evaluation of the fetal heart rate patterns preceding death. Am J Obstet Gynecol. 1965;87:814–26.
McCain GC, Fuller EO, Gartside PS. Heart rate variability and feeding bradycardia in healthy preterm infants during transition from gavage to oral feeding. Newborn Infant Nurs Rev. 2005;5(3):124–32.
McCain GC, Ludington-Hoe SM, Swinth JY, Hadeed AJ. Heart rate variability responses of a preterm infant to kangaroo care. J Obstet Gynecol Neonatal Nurs. 2005;34:689–94.
Hirst M. Heart rate variability in the fetus. In: Malik M, Gamm AJ, editors. Heart rate variability. Armonk: Futura; 1995. p. 517–31.
Shoemaker WC, Bernad P, Colombo J. ANS monitoring in closed head injury patients. In: Bernad P, editor. Closed head injury. Newark: LexisNexis Group; 2006. p. 481–97.
Shoemaker WC, Wo CCJ, Bishop MH. Multicenter trial of a new thoracic electric bio-impedance device for cardiac output estimation. Crit Care Med. 1994;22:1907–12.
Wo CCJ, et al. Noninvasive estimations of cardiac output and circulatory dynamics in critically ill patients. Curr Opinion Crit Care. 1995;1:211–8.
Shoemaker WC, Belzberg H, Wo CCJ, Milzman DP, Pasquale L, Baga L, Fuss MA, Fulda GJ, Yarbrough K, Van de Water JP. Multicenter study of noninvasive monitoring as alternative to invasive monitoring in early management of acutely ill emergency patients. Chest. 1998;114:1643–52.
Colombo J, Iffrig K, Wo CCJ, Aysin E, Aysin B, Colombo A, Shoemaker WC. Autonomic function can evaluate brain stem function to determine viability of life. Society Critical Care Medicine, 36th Critical Care Congress. Orlando, 17–21 Feb 2007.
Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2002;345:1368–77.
Shoemaker WC, Colombo A, Colombo J. ANS-based early goal-directed therapy in the treatment of severe sepsis and septic shock: preliminary evidence. Presented at the American College of Chest Physicians Annual Meeting, 31 Oct–2 Nov 2005.
Colombo J, Shoemaker WC, Wo CCJ, Aysin E, Belzberg H. Role of autonomic activity in the hemodynamic pattern of septic shock. Presented at the 72nd annual international scientific assembly of the American College of Chest Physicians, 2006.
Hankeln KB, Senker R, Schwarten JN, et al. Evaluation of prognostic indices based on hemodynamic and oxygen transport variables in shock patients with ARDS. Crit Care Med. 1987;15:1–7.
Bishop MW, Shoemaker WC, Kram HB, Ordog GJ, et al. Prospective randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation end points in severe trauma. J Trauma. 1995;38:780–7.
Bishop MW, Shoemaker WC, Appel PL, et al. Relationship between supranormal values, time delays and outcome in severely traumatized patients. Crit Care Med. 1993;21:56–61.
Wang X, Sun HH, Adamson D, Van De Water JM. An impedance cardiography system: a new design. Ann Biomed Eng. 1989;17:535–56.
Wang X, Sun HH, Van de Water JM. An advance signal processing technique for impedance cardiography. IEEE Trans Biomed Eng. 1995;42:224–30.
Tremper KK, Waxman K, Shoemaker WC. Effects of hypoxia and shock on transcutaneous PO2 values in dogs. Crit Care Med. 1979;7:526–31.
Tremper KK, Shoemaker W. Transcutaneous oxygen monitoring of critically ill adults with and without low flow shock. Crit Care Med. 1981;9:706–9.
Severinghaus JW, Stafford M, Thunstrom A. Estimation of skin metabolism and blood flow with tcPO2 and tcPCO2 electrodes by cuff occlusion of the circulation. Acta Anaesthesiol Scand Suppl. 1978;68:9–15.
Tremper KK, Shoemaker WC, Shippy CR, et al. Transcutaneous carbon dioxide monitoring on adult patients in the ICU and operating room. Crit Care Med. 1981;9:752–5.
Tremper KK, Huxtable RF. Dermal heat transport analysis for transcutaneous O2 measurements. Acta Anaesthesiol Scand Suppl. 1978;68:4–8.
Tremper KK, Waxman K, Bowman R, et al. Continuous transcutaneous oxygen monitoring during respiratory failure, cardiac decompensation, cardiac arrest, and CPR. Crit Care Med. 1980;8:337–81.
Tatevossian RG, Wo CCJ, Velmahos GC, et al. Transcutaneous oxygen and CO2 as early warning of tissue hypoxia and hemodynamic shock in critically ill emergency patients. Crit Care Med. 2000;28:2248–53.
Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS. Prospective trial of supranormal values of survivors as therapeutic goals in high risk surgical patients. Chest. 1988;94:1176–84.
Freeman R. Assessment of cardiovascular autonomic function. Clin Neurophysiol. 2006;117(4):716–30.
Uijtdehaage SH, Thayer JF. Accentuated antagonism in the control of human heart rate. Clin Auton Res. 2000;3:107–10.
Williams CA, Lopes P. The influence of ventilator control on heart rate variability in children. J Sports Sci. 2002;5:407–15.
Vinik AI, Freeman R, Erbas T. Diabetic autonomic neuropathy. Semin Neurol. 2003;23:365–72.
Vinik AI, Arora RR, Colombo J. Age matched attenuation of both autonomic branches in chronic disease: II. Diabetes mellitus. Cleveland clinic heart-brain summit, Cleveland Clinic Lou Ruvo Center for Brain Health. Las Vegas, 23–24 Sep 2010.
Gelin L-E. Studies in the anemia of injury. Acta Chir Scand Suppl. 1956;210:81–95.
Shoemaker WC, Appel PL, Kram HB. Role of oxygen debt in the development of organ failure, sepsis and death in high-risk surgical patients. Chest. 1992;102:208–15.
Shoemaker WC, Bayard DS, Botnen A, Wo CCJ, et al. Mathematical program for outcome prediction and therapeutic support for trauma beginning within 1 hour of admission. Crit Care Med. 2005;33:1499–506.
Robertson D, Bisggioni I, Burnstock G, Low PA, Paton JFR, editors. Primer on the autonomic nervous system. 3rd ed. Waltham: Academic; 2012.
Boyd O, Grounds M, Bennett D. Preoperative increase of oxygen delivery reduces mortality in high risk surgical patients. JAMA. 1993;270:2699–707.
Parati, G. and Rizzoni D. Assessing the prognostic relevance of blood pressure variability: discrepant information from different indices. J Hypertens. 2005;23(3):483–6.
Yu M, Levy MM, Smith P, Takiguchi SA, Myers SA. Effect of maximizing oxygen delivery on mortality and mortality rates in critically ill patients: a prospective randomized controlled study. Crit Care Med. 1993;21:830–8.
Scalea TM, Simon HM, Duncan AO, Atweh NA, Schafani SJ, Phillips TF, Shaftan GW. Geriatric blunt multiple trauma: improved survival with early invasive monitoring. J Trauma. 1990;30:29–34.
Wilson J, Woods I, Faucett J, Whall R, Dibb W, Morris C, McManus E. Reducing the risk of major elective surgery: randomized controlled trial of preoperative optimization of oxygen delivery. Brit Med J. 1999;318:1099–103.
Berlauk JF, Abrams JH, Gilmour IJ. Preoperative optimization of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. Ann Surg. 1991;214:189–97.
Moore FA, Haemel JB, Moore EE, Whitehill TA. Incommensurate oxygen consumption in response to maximal oxygen availability predicts postinjury multiple organ failure. J Trauma. 1992;33:58–65.
Yu M, Burchell S, Hasaniya NWMA, Takanishi DM, Myers SA. Relationship of mortality to increasing oxygen delivery in patients >50 years of age: a prospective, randomized trial. Crit Care Med. 1998;26:1011–9.
Kern JW, Shoemaker WC. Meta-analysis of hemodynamic optimization in high risk patients. Crit Care Med. 2002;30:1686–92.
Colombo J, Shoemaker WC, Wo CCJ, Aysin E, Belzberg H. Gender differences of hemodynamic and autonomic activity in septic shock. Presented at the 72nd annual international scientific assembly of the American College of Chest Physicians;. 2006.
Dutton R, Shoemaker WC, Blood C, Woo C, Colombo J. Examination of real-time heart rate variability during active hemorrhage. Navy Report, NHRC, San Diego; 2001.
Barak Y, David D, Keselbrener L, Akselrod S. Autonomic response to hypobaric hypoxia assessed by time-dependent frequency decomposition of heart rate. Aviat Space Environ Med. 2001;72(11):992–1000.
Gordon D, Herrera VL, McAlpine L, Cohen RJ, Akselrod S, Lang P, Norwood WI. Heart-rate spectral analysis: a noninvasive probe of cardiovascular regulation in critically ill children with heart disease. Pediatr Cardiol. 1988;9(2):69–77.
Shoemaker WC, Wo CCJ, Demetriades D. Early physiological patterns in acute illness and accidents. New Horiz. 1996;4:395–412.
Guilleminault C, Faul JL, Stoohs R. Sleep-disordered breathing and hypotension. Am J Respir Crit Care Med. 2001;164(7):1242–7.
Shoemaker WC, Wo CCJ, Chan L, Ramicone E, Kamel ES, Velmahos GC, Belzberg H. Outcome prediction of emergency patients by noninvasive hemodynamic monitoring. Chest. 2001;120:528–37.
Shoemaker WC, Wo CCJ, Thangathurai D, et al. Hemodynamic patterns of survivors and non-survivors during high risk elective surgical operations. World J Surg. 1999;23:1264–71.
Shoemaker WC, Wo CCJ, Yu S, Farjam F, Thangathuria D. Invasive and noninvasive haemodynamic monitoring of acutely ill sepsis and septic shock patients in the emergency department. Eur J Emerg Med. 2000;7:169–75.
Raaijmakers E, Faes TJC, Scholton RJPM, et al. A meta-analysis of three decades of validating thoracic impedance cardiography. Crit Care Med. 1999;27:1203–13.
Knisely MH, Block EH, Eliot TS. Warner l: sludged blood. Science. 1947;106:431.
Chidsey CA, Braunwald E. Sympathetic activity and neurotransmitter depletion in congestive heart failure. Pharmacol Rev. 1966;18:685–700.
Sibley DR, Lefkowitz RJ. Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor coupled adenylate cyclase system as a model. Nature. 1985;317:124–9.
Pomeranz B, Macaulay RJ, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ, et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985;248(1 pt 2):H151–3.
Saul JP. Beat-to-beat variations of heart rate reflect modulation of cardiac outflow. Physiology. 1990;5:32–7.
Toledo E, Pinhas I, Aravot D, Almog Y, Akselrod S. Functional restitution of cardiac control in heart transplant patients. Am J Physiol Regul Integr Comp Physiol. 2002;282(3):R900–8.
Bernardi L, Bianchini B, Spadacini G, Leuzzi S, Valle F, Marchesi E, Passino C, Calciati A, Viganó M, Rinaldi M, et al. Demonstrable cardiac reinnervation after human heart transplantation by carotid baroreflex modulation of RR interval. Circulation. 1995;92(10):2895–903.
Gordon D, Cohen RJ, Kelly D, Akselrod S, Shannon DC. Sudden infant death syndrome: abnormalities in short term fluctuations in heart rate and respiratory activity. Pediatr Res. 1984;18(10):921–6.
Sadeh D, Shannon DC, Abboud S, Saul JP, Akselrod S, Cohen RJ. Altered cardiac repolarization in some victims of sudden infant death syndrome. N Engl J Med. 1987;317(24):1501–5.
Shannon DC, Kelly DH, Akselrod S, Kilborn KM. Increased respiratory frequency and variability in high risk babies who die of sudden infant death syndrome. Pediatr Res. 1987;22(2):158–62.
Davidson S, Reina N, Shefi O, Hai-Tov U, Akselrod S. Spectral analysis of heart rate fluctuations and optimum thermal management for low birth weight infants. Med Biol Eng Comput. 1997;35(6):619–25.
Shefi O, Davidson S, Maayan A, Akselrod S. The effect of thermal stimulation on the heart-rate variability in neonates. Early Hum Dev. 1998;52(1):49–66.
Verklan MT, Padhye NS. Spectral analysis of heart rate variability: an emerging tool for assessing stability during transition to extrauterine life. J Obstet Gynecol Neonatal Nurs. 2004;33:256–65.
Sahni R, Schulze KF, Kashyap S, Ohira-Kist K, Fifer WP, Myers MM. Maturational changes in heart rate variability in low birth weight infants. Dev Psychobiol. 2000;37:73–81.
Chatow U, Davidson S, Reichman BL, Akselrod S. Development and maturation of the autonomic nervous system in premature and full-term infants using spectral analysis of heart rate fluctuation. Pediatr Res. 1995;37:294–302.
Mehta SK, Super DM, Salvator A, Singer L, Connuck D, Fradley LG, et al. Heart rate variability in cocaine-exposed newborn infants. Am Heart J. 2001;142:828–32.
Henslee JA, Schechtman VL, Lee MY, Harper RM. Developmental patterns of heart rate and variability in prematurely-born infants with apnea of prematurity. Early Hum Dev. 1997;47:35–50.
Griffin MP, O’Shea TM, Bissonette EA, Harrell FE, Lake DE, Moorman JR. Abnormal heart rate characteristics preceding neonatal sepsis and sepsis like illness. Pediatr Res. 2003;53:920–6.
Smith SL. Heart period variability of intubated very low- birth-weight infants during incubator care and maternal holding. Am J Crit Care. 2003;12:54–64.
Feldman R, Eidelman AI. Skin-to-skin contact (kangaroo care) accelerates autonomic and neurobehavioural maturation in preterm infants. Dev Med Child Neurol. 2003;45:274–81.
Schrod L, Walter J. Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants. Biol Neonate. 2002;81:255–9.
Eiselt M, Curzi-Dascalova L, Clairambault J, Kauffmann F, Medigue C, Peirano P. Heart-rate variability in low-risk prematurely born infants reaching normal term: a comparison with full-term newborns. Early Hum Dev. 1993;32:183–95.
Rothwell PM, Algra A, Amarenco P. Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke. Lancet. 2011;377(9778):1681–92.
Shoemaker WC, Bernad PG, Colombo J. ANS monitoring in closed head injury patients. Autonomic and hemodynamic patterns after head trauma and brain death. Society Critical Care Medicine, 36th critical care congress, Orlando, 17–21 Feb 2007.
Belzberg H, Colombo J, Shoemaker WC, Wo CCJ. Autonomic and hemodynamic patterns after head trauma and brain death. Society Critical Care Medicine, 36th Critical Care Congress. Orlando, 17–21 Feb 2007.
Arora RR, Bulgarelli RJ, Ghosh-Dastidar S, Colombo J. Autonomic mechanisms and therapeutic implications of postural diabetic cardiovascular abnormalities. J Diabetes Sci Technol. 2008;2(4):568–71.
Korpelainen JT, et al. Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction. Acta Neurol Scand. 1996;94:337–42.
Korpelainen JT, et al. Abnormal heart rate variability as a manifestation of autonomic dysfunction in hemispheric brain infarction. Stroke. 1996;27:2059–63.
Barron SA, Rogovski Z, Hemli J. Autonomic consequences of cerebral hemisphere infarction. Stroke. 1994;25:113–6.
Orlandi G, et al. Transient autonomic nervous system dysfunction during hyperacute stroke. Acta Neurol Scand. 2000;102:317–21.
Low PA, Engstrom JW. Disorders of the autonomic nervous system. In: Harrison’s principles of internal medicine. 16th ed. New York: McGraw-Hill; 2003.
Munakata M, Kameyama J, Nunokawa T, Ito N, Yoshinaga K. Altered Mayer wave and baroreflex profiles in high spinal cord injury. Am J Hypertens. 2001;14(2):141–8.
Arora RR, Ghosh Dastidar S, Colombo J. Autonomic balance is associated with decreased morbidity. American Autonomic Society, 17th International Symposium. Kauai, 29 Oct–1 Nov 2008.
Brown RS, Mohr PA, Carey JS, Shoemaker WC. Cardiovascular changes after cranial cerebral injury and increased intracranial pressure. Surg Gynecol Obstet. 1967;125:1205–11.
Brown RS, Shoemaker WC. Sequential hemodynamic changes in patients with head injury. Ann Surg. 1973;177:187–92.
Schulte am Esch J, Murday H, Pfeifer G. Haemodynamic changes in patients with severe head injury. Acta Neurochir. 1980;54:243–50.
Popp AJ, Gottlieb ME, Paloski WH, et al. Cardiopulmonary hemodynamics in patients with serious head injury. J Surg Res. 1982;32:416–21.
McLeod AA, Neil-Dwyer G, Meyer CHA, et al. Cardiac sequelae of acute head injury. Br Heart J. 1982;47:221–6.
Clifton GL, Robertson CS, Kyper K, et al. Cardiovascular response to severe head injury. J Neurosurg. 1983;59:447–54.
Deutschman CS, Konstantinides FN, Raup S, Thienprasit P, Cerra FB. Physiological and metabolic response to isolated closed-head injury. J Neurosurg. 1986;64:89–98.
Vicario SJ, Coleman R, Cooper MA, Thomas DM. Ventilatory status early after head injury. Ann Emerg Med. 1983;12:145–8.
Nicholls TP, Shoemaker WC, Wo CCJ, Gruen JP, et al. Tissue oxygenation after head trauma is related to survival; a preliminary report. J Am Coll Surg. (in Press).
Teasdale G, Jennett B. Assessment of coma and impaired consciousness: a practical scale. Lancet. 1974;ii:81–3.
Cushing H. Concerning a definitive regulatory mechanism of the vaso-motor centre which controls blood pressure during cerebral compression. Bull Hosp Johns Hopkins. 1901;12:290–2.
Davis DH, Sundt Jr TM. Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats. J Neurosurg. 1980;52:745–54.
Richardson TQ, Fermoso JD, Pugh GO. Effect of acutely elevated intracranial pressure on cardiac output and other circulatory factors. J Surg Res. 1965;5:318–22.
Price HL. Effects of carbon dioxide on the cardiovascular system. Anesthesiology. 1960;21:652–63.
Sechzer PH, Egbert LD, Linde HW, et al. Effect of CO2 inhalation on arterial pressure, EKG, catecholamines and 17-OH corticosteroids in normal man. J Appl Phys. 1960;15:454–8.
Turney SZ, Labrosse E, Paul R, et al. The sympathetic response in head trauma; catecholamines and cardiopulmonary changes upon altering PCO2. Ann Surg. 1972;77:86–92.
Rowe MI, Weinberg G. Transcutaneous oxygen monitoring in shock and resuscitation. J Pediatr Surg. 1979;14:773–8.
Jäättelä A, Ahlo A, Avikainen V, et al. Plasma catecholamines in severely injured patients: a prospective study on 45 patients with multiple injuries. Br J Surg. 1975;62:177–81.
Halter JB, Pflug AE, Porte Jr D. Mechanisms of plasma catecholamines increases during surgical stress in man. J Clin Endocrinol Metab. 1977;45:936–44.
Maddens M, Sowers J. Catecholamines in critical care. Crit Care Clin. 1987;3:871–2.
Waxman K. Physiologic response to injury. In: Shoemaker WC, Ayres SA, Grenvik A, Holbrook P, editors. Textbook of critical care. Philadelphia: W.B. Saunders Co.; 1995. p. 1395–402.
Waxman K. Shock: ischemia, reperfusion and inflammation. New Horiz. 1996;4:153–60.
Gann DS, Lilly MP. The neuroendocrine response to multiple trauma. World J Surg. 1993;7:101–18.
Lubbers DW. Theoretical basis of the transcutaneous blood gas measurements. Crit Care Med. 1981;9:721–33.
Boyd O, Bennett D. Enhancement of perioperative tissue perfusion as a therapeutic strategy for major surgery. New Horiz. 1996;4:453–65.
Zornow MH, Prough DS. Fluid management in patients with traumatic head injury. New Horiz. 1995;3:488–98.
Tonnesen AS. Hemodynamic management of brain injured patients. New Horiz. 1996;4:499–05.
Zhuang J, Shackford SR, Schomaker JD, Pietropaoli JA. Colloid infusion after brain injury: effect on intracranial pressure, cerebral blood flow, and O2 delivery. Crit Care Med. 1995;23:140–8.
Bullock R, Chesnut RM, Clifton G, Ghujar J, et al. Consensus conference. J Neurotrauma. 1996;11:667–709.