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Prevention of Infection: The Host Factors

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Perioperative Medical Management for Total Joint Arthroplasty

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Abstract

Orthopedic device-related infections are relatively uncommon (0.6–2.5 % for primary and up to 10–20 % for revision) (Jamsen et al. 2010; Urquhart et al. 2010; Cataldo et al. 2010; Moran et al. 2010; Peel et al. 2011; Shuman et al. 2012). They cause significant morbidity and mortality and an elevated health care expenditure (three times more than first implants).

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References

  • Atkins BL, Athanasou N, Deeks JJ, Crook DW, Simpson H, Peto TE, McLardy-Smith P, Berendt AR (1998) Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group. J Clin Microbiol 36(10):2932–2939

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cataldo MA, Petrosillo N, Cipriani M, Cauda R, Tacconelli E (2010) Prosthetic joint infection: recent developments in diagnosis and management. J Infect 61:443–448

    Article  PubMed  Google Scholar 

  • Cierny G 3rd, DiPasquale D (2002) Periprosthetic total joint infections. Staging, treatment, and outcomes. Clin Orthop Relat Res 403:23–28

    Article  PubMed  Google Scholar 

  • Cierny G 3rd, Mader JT, Penninck JJ (2003) A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res 414:7–24

    Article  PubMed  Google Scholar 

  • Costerton JW, Stewart PS, Greenberg EP (1999) Bacterial biofilms: a common cause of persistent infections. Science 284(5418):1318–1322

    Article  CAS  PubMed  Google Scholar 

  • Coventry MB (1975) Treatment of infection occurring in total hip surgery. Orthop Clin North Am 6:991–1003

    CAS  PubMed  Google Scholar 

  • Estes CS, Beauchamp CP, Clarke HD, Spangehl MJ (2010) A two-stage retention debridement protocol for acute periprosthetic joint infections. Clin Orthop Relat Res 468:2029–2038

    Article  PubMed Central  PubMed  Google Scholar 

  • Ghanem E, Azzam K, Seeley M, Joshi A, Parvizi J (2009) Staged revision for knee arthroplasty infection: what is the role of serologic tests before reimplantation? Clin Orthop Relat Res 467:1699–1705

    Article  PubMed Central  PubMed  Google Scholar 

  • Gould KF, Brindle R, Chadwick PR, Fraise AP, Hill S, Nathwani D, Ridgway GL, Spry MJ, Warren RE (2009) Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom. J Antimicrob Chemother 63(5):849–861

    Article  CAS  PubMed  Google Scholar 

  • Greidanus NV, Masri BA, Garbuz DS, Wilson SD, McAlinden MG, Xu M, Duncan CP (2007) Use of erythrocyte sedimentation rate and C-reactive protein level to diagnose infection before revision total knee arthroplasty. J Bone Joint Surg Am 89:1409–1416

    Article  PubMed  Google Scholar 

  • Hidron AI, Edwards JR, Patel J et al (2008) NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Center for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol 29(11):996–1011

    Article  PubMed  Google Scholar 

  • Jafari SM, Coyle C, Mortazavi SM, Sharkey PF, Parvizi J (2010) Revision hip arthroplasty. Infection in the most common cause of failure. Clin Orthop Relat Res 468:2046–2051

    Article  PubMed Central  PubMed  Google Scholar 

  • Jamsen E, Varonen M, Huhtala H, Letho MU, Lumio J, Konttinen YT, Moilanen T (2010) Incidence of prosthetic joint infections after primary knee arthroplasty. J Arthroplasty 25:87–92

    Article  PubMed  Google Scholar 

  • Kurd MF, Ghanem E, Steinbrecher J, Parvizi J (2010) Two-stage exchange knee arthroplasty: does resistance of the infected organism influence the outcome? Clin Orthop Relat Res 468:2060–2066

    Article  PubMed Central  PubMed  Google Scholar 

  • Laudermilch DJ, Fedorka CJ, Heyl A, Rao N, McGough RL (2010) Outcomes of revision of total knee arthroplasty after methicillin-resistant staphylococcus aureus infection. Clin Orthop Relat Res 468:2067–2073

    Article  PubMed Central  PubMed  Google Scholar 

  • McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis M (2002) Periprosthetic total hip infection. Outcomes using a staging system. Clin Orthop Relat Res 403:8–15

    Article  PubMed  Google Scholar 

  • Mittal Y, Fehring TK, Hanssen A, Marculescu C, Odum SM, Osmon D (2007) Two-stage reimplantation for periprosthetic knee infection involving resistant organisms. J Bone Joint Surg Am 89:1227–1231

    Article  PubMed  Google Scholar 

  • Moran E, Byren I, Atkins BL (2010) The diagnosis and management of prosthetic joint infections. J Antimicrob Chemother 65(suppl 3):45–54

    Google Scholar 

  • Mortazavi SM, Schwartzenberger J, Austin MS, Purtill JJ, Parvizi J (2010) Revision total knee arthroplasty infection. Incidence and predictors. Clin Orthop Relat Res 468:2052–2059

    Article  PubMed Central  PubMed  Google Scholar 

  • Peel TN, Buising KL, Choong PF (2011) Prosthetic joint infection: challenges of diagnosis and treatment. ANZ J Surg 81:32–39

    Article  PubMed  Google Scholar 

  • Prokuski L (2008) Prophylactic antibiotics in orthopaedic surgery. J Am Acad Orthop Surg 16:283–293

    PubMed  Google Scholar 

  • Senneville E, Joulie D, Legout L et al (2009) Outcome and predictors of treatment failure in total hip/knee prosthetic joint infections due to Staphylococcus aureus. Clin Infect Dis 53(4):334–340

    Article  Google Scholar 

  • Shuman EK, Urquhart A, Malani PN (2012) Management and prevention of prosthetic joint infection. Infect Dis Clin North Am 26:29–39

    Article  PubMed  Google Scholar 

  • Trampuz A, Widmer AF (2006) Infections associated with orthopedic implants. Curr Opin Infect Dis 19:349–356

    Article  CAS  PubMed  Google Scholar 

  • Trampuz A, Zimmerli W (2005) Prosthetic joint infections: update in diagnosis and treatment. Swiss Med Wkly 135:243–251

    PubMed  Google Scholar 

  • Trampuz A, Zimmerli W (2006a) Antimicrobial agents in orthopaedic surgery: prophylaxis and treatment. Drugs 66:1089–1105

    Article  CAS  PubMed  Google Scholar 

  • Trampuz A, Zimmerli W (2006b) Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 37(Suppl 2):59–66

    Article  Google Scholar 

  • Tsukayama DT, Estrada R, Gustilo RB (1996) Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J Bone Joint Surg Am 78(4):512–523

    CAS  PubMed  Google Scholar 

  • Urquhart DM, Hanna FS, Brennan SL, Wluka AE, Leder K, Cameron PA, Graves SE, Cicuttini FM (2010) Incidence and risk factors for deep surgical site infection after primary total hip arthroplasty: a systematic review. J Arthroplasty 25:1216–1222

    Article  PubMed  Google Scholar 

  • Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. N Engl J Med 351:1645–1654

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Hip Orthopedics and Prosthesis, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan, 20089, Italy

    Matteo Carlo Ferrari & Guido Grappiolo

Authors
  1. Matteo Carlo Ferrari
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  2. Guido Grappiolo
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Correspondence to Matteo Carlo Ferrari .

Editor information

Editors and Affiliations

  1. Humanitas Clinical and Research Center, Milan, Italy

    Andrea Baldini

  2. San Donato Hospital, Arezzo, Italy

    Patrizio Caldora

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Ferrari, M.C., Grappiolo, G. (2015). Prevention of Infection: The Host Factors. In: Baldini, A., Caldora, P. (eds) Perioperative Medical Management for Total Joint Arthroplasty. Springer, Cham. https://doi.org/10.1007/978-3-319-07203-6_18

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  • DOI: https://doi.org/10.1007/978-3-319-07203-6_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07202-9

  • Online ISBN: 978-3-319-07203-6

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