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Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

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Handbook of Anticancer Drugs from Marine Origin

Abstract

Cancer is most common in worldwide and badly threaten to human’s life. Unfortunately drugs, which are used for cancer therapy, are toxic and affect not only cancer cells but also normal cells and tissues. At last decade marine brown algae attract much attention because they represent a rich and easily regenerated source of polysaccharides with various structures and biological activities. Fucoidan sulfated polysaccharides (FCSPs) extracted from seaweeds, mainly brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Fucoidan was shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. Hence, this chapter deals the potential role of fucoidan on cancer therapeutics.

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Acknowledgements

This study was supported by a grant from Marine Bioprocess Research Center of the Marine Bio 21 Project funded by the Ministry of Land, Transport and Maritime, Republic of Korea.

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  1. Specialized Graduate School Science & Technology Convergence, Department of Marine-Bio Convergence Science, Marine Bioprocess Research Center, Pukyong National University, Yongdong Campus, 365, Sinseon-ro, Nam-gu, Busan, 608-739, Republic of Korea

    Dr. Senthilkumar Kalimuthu & Prof. Se-Kwon Kim

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  1. Dr. Senthilkumar Kalimuthu
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  2. Prof. Se-Kwon Kim
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Correspondence to Se-Kwon Kim .

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  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Kalimuthu, S., Kim, SK. (2015). Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_7

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