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P-gp Inhibitory Activity from Marine Sponges, Tunicates and Algae

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Handbook of Anticancer Drugs from Marine Origin

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Abstract

The only effective therapy for metastasis in cancer patients is chemotherapy, which all too frequently fails due to innate or acquired multi-drug resistance (MDR). Historically, ATP binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), are recognized as the major culprits responsible for MDR. Over-expressing of P-gp in cancer cells, can lead to premature efflux of clinical chemotherapeutic agents and correlate with poor chemotherapeutic outcome and relapse of some cancers. The most likely strategy to overcome MDR is to search for inhibitors from natural products. With unique and novel chemical structures, marine-derived metabolites are an attractive new resource, to prime the search for new P-gp inhibitors. This chapter summarizes P-gp inhibitory activity in marine natural products (MNPs) and validates that MNPs can deliver new ABC transporter inhibitor scaffolds.

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Authors and Affiliations

  1. Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

    Xiao-cong Huang & Xue Xiao

  2. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York, NY, USA

    Priyank Kumar, Nagaraju Anreddy & Zhe-Sheng Chen

  3. Biosample Repository Facility, Fox Chase Cancer Center, Philadelphia, PA, USA

    Dong-Hua Yang

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  1. Xiao-cong Huang
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  2. Priyank Kumar
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  3. Nagaraju Anreddy
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  4. Xue Xiao
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Correspondence to Zhe-Sheng Chen .

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  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Huang, Xc., Kumar, P., Anreddy, N., Xiao, X., Yang, DH., Chen, ZS. (2015). P-gp Inhibitory Activity from Marine Sponges, Tunicates and Algae. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_28

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