Advertisement

Technological Development in Therapeutic Applications of Alternating Electric Fields: Review

  • S. TaleleEmail author
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 313)

Abstract

A number of bacteria, virus and other unhealthy cells need to be killed for getting rid of them. For more than a century antibiotics have been effectively used for killing bacterial pathogens and chemical drugs against the cancer cells. However, there are bacteria and cancer cells that are drug resistant. This may have to be overcome by other stronger drugs, higher dosage. These can have detrimental side effects. Other non drug methods to aid the effect of these drugs have always been in research. Electrochemotherapy, a method of using electric fields along with the drug to be used topically has been one of the successful approaches. One of the most recent methods of Tumor Treating Frequencies (TTF) for a brain cancer has been FDA approved. This article details the use of TTF. The article also details some other latest research where alternating fields are used as antibacterial agents.

Keywords

Alternating electric field Biomedical applications 

References

  1. 1.
    Caubet, R., F. Pedarros-Caubet, M. Chu, E. Freye, M. de Belem Rodrigues, J. M. Moreau, and W. J. Ellison. 2004. A radio frequency electric current enhances antibiotic efficacy against bacterial biofilms. Antimicrob. Agents Chemother. 48:4662–4664.Google Scholar
  2. 2.
    Del Pozo, J. L., M. S. Rouse, G. Euba, C. I. Kang, J. N. Mandrekar, J. M. Steckelberg, and R. Patel. 2009. The electricidal effect is active in an experimental model of Staphylococcus epidermidis chronic foreign body osteomyelitis. Antimicrob. Agents C hemother. 53:4064–4068.Google Scholar
  3. 3.
    Rabinovitch, C., and P . S. Stewart. 2006. Removal and inactivation of Staphylococcus epidermi dis biofilms by electrolysis. Appl. Environ. Microbiol. 72:6364–6366.Google Scholar
  4. 4.
    van der Borden, A. J., H. van der Werf, H. C. van der Mei, and H. J. Busscher. 2004. Electric current-induced detachment of Staphylococcus epidermidis biofilms from surgical stainless steel. Appl. Environ. Microbiol. 70:6871–6874Google Scholar
  5. 5.
    Ensing, G. T., B. L. Ro eder, J. L. Nelson, J. R. van Horn, H. C. van der Mei, H. J. Busscher, and W. G. Pitt. 2005. Effect of pulsed ultrasound in combination with gentamicin on bacterial viability in biofilms on bone cements in vivo. J. Appl. Microbiol. 99:443–448Google Scholar
  6. 6.
    Rediske, A. M., N. Rapoport, and W. G. Pitt. 1999. Reducing bacterial resistance to antibiotics with ultrasound. Lett. Appl. Microbiol. 28:81–84Google Scholar
  7. 7.
    Pitt, W. G., M. O. McB ride, J. K. Lunceford, R. J. Roper, and R. D. Sagers. 1994. Ultrasonic enhancement of antibiotic action on gram-negative bacteria. Antimicrob. Agents Chemother. 38:2577–2582.Google Scholar
  8. 8.
    Reithinger, R., M. Mohsen, M. Wahid, M. Bismullah, R. J. Quinnell, C. R. Davies, J. Kolaczinski, and J. R. David. 2005. Efficacy of thermotherapy to treat cutaneous leishmaniasis caused b y Leishmania tropica in Kabul, Afghanistan: a randomized, controlled trial. Clin. Infect. Dis. 40:1148–1155.Google Scholar
  9. 9.
    Jori, G., C. Fabris, M. Soncin, S. Ferro, O. Coppellotti, D. Dei, L. Fantetti, G. Chiti, and G. Roncucci. 2006. Photodynamic therap y in the treatment of microbial infections: basic principles and perspective applications. Lasers Surg. Med. 38:468–481.Google Scholar
  10. 10.
    Zolfaghari, P. S., S. Packer, M. Singer, S. P. Nair, J. Bennett, C. Street, and M. Wilson. 2009. In vivo killing of Staphylococcus aureus using a lightactivated antimicrobial agent. BMC Microbiol. 9:27.Google Scholar
  11. 11.
    Oleinick, N. L., and H. H. Evans. 1998. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res. 150:S146–S156.Google Scholar
  12. 12.
    Liu, W. K., M. R. Bro wn, and T. S. Elliott. 1997. Mechanisms of the bactericidal activity of low amperage electric current (DC). J. Antimicrob. Chemother. 39:687–695.Google Scholar
  13. 13.
    Polk, C. Therapeutic application s of low-frequency sinusoidal and pulsed electric and magnetic fields. In: Bronzino JD, editor, The biomedical engineering handbook. CRC Press, Inc., Boca Raton, FL; 1995. p. 1404-16Google Scholar
  14. 14.
    Palti, Y. J. Stimulation of internal organs by means of externally applied electrodes. Appl Physiol 1966;21(5):1619-12.Google Scholar
  15. 15.
    Bassett, C.A. The development and application of pulsed electromagnetic fields (PEMFs) for ununited fractures and arthrodeses. Clin Plast Surg 1985;20:259-77.Google Scholar
  16. 16.
    Elson, E. Biologic effects of radiofrequency and microwave fields: in vivo and in vitro experimental results. In: Bronzino JD, editor, The biomedical engineering handbook. CRC Press, Inc., Boca Raton, FL; 1995. p. 1417-Google Scholar
  17. 17.
    Chou, C. K. Radiofrequency hyp erth ermia in cancer therapy. In: Bronzino JD, editor. The biomedical engineering handbook. CRC Press, Inc., Boca Raton, FL; 1995. p. 1424-30Google Scholar
  18. 18.
    Goater, A. D, Pethig, R. Electrorotation and dielectrophoresis. Parasitology 1998;117(Suppl):S177-89Google Scholar
  19. 19.
    C. Chen, J.A. Evans, M.P. Robinson, S.W. Smye, P. O'Toole. Measurement of the efficiency of cell membrane electroporation using pulsed ac fields, Phys. Med. Biol. 53 (2008) 4747–4757.Google Scholar
  20. 20.
    Talele, S., P. Gaynor, J. van Ekeran, and M. J. Cree. Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii. Journal of Electrostatics, 68, pp. 261-274 (2010).Google Scholar
  21. 21.
    Kirson, E. D, Gurvich, Z., Schneiderman, R., et al. Disruption of cancer cell replication by alternating electric fields. Cancer Res 2004;64(9):3288-95. TTFields significantly inhibited different cancer cell lines by disrupting cells undergoing mitosis.Google Scholar
  22. 22.
    Kirson, E.D., Dbaly, V,, Tovarys, F., et al. Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci USA 2007;104(24):10152-7Google Scholar
  23. 23.
    Clague, D.S., Wheel er, E.K. Dielectrophoretic manipulation of macromolecules: the el ectric field. Phys Rev E Stat Nonlin Soft Matter Phys 2001;64(2 Pt 2):026605Google Scholar
  24. 24.
    Gonzalez, C.F., Remcho, V. T., Harnessing dielectric forces for separations of cells, fine particles and macromolecules. J Chromatogr A 2005;1079(1-2):59-68Google Scholar
  25. 25.
    Webster, J.G., Clark, J. W., Medical Instrumentation: application and design. Wiley, New York; 1998Google Scholar
  26. 26.
    Burnette, R. R., Ongpipattanakul, B. Characterization of the pore transport properties and tissue alteration of excised human skin during iontophoresis. J Pharm Sci 1988;77(2):132-7Google Scholar
  27. 27.
    Miklos, Pless† & Uri, Weinberg. Tumor treating fields: concept, evidence and future, Expert Opin. Investig. Drugs (2011) 20(8)Google Scholar
  28. 28.
    Kirson, E. D., Schneiderman, R. S., Dbaly, V., et al. Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields). BMC Med Phys 2009;9:1Google Scholar
  29. 29.
    Kirson, E. D., Giladi, M., Gurvich, Z., et al. Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs. Clin Exp Metastasis 2009;26(7):633-40Google Scholar
  30. 30.
    Giladi, M., Y. Porat, A. Blatt, Y. Wasserman, E. D. Kirson, E. Dekel, and Y. Palti. 2008. Microbial growth inhibition by alternating electric fields. Antimicrob. Agents Chemother. 52:3517–3522.Google Scholar
  31. 31.
    Moshe Giladi, Yaara Porat, Alexandra Blatt, Esther Shmueli, Yoram Wasserman, Eilon D. Kirson, and Yoram Palti, Microbial Growth Inhibition by Alternating Electric Fields in Mice with Pseudomonas aeruginosa Lung Infection, Antimicrob. Agents Chemother. Aug. 2010, p. 3212-3218.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.The University of WaikatoHamiltonNew Zealand

Personalised recommendations