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Information Technologies in Biomedicine, Volume 3 pp 317–326Cite as

Simulation Analysis of the ATR Module as a Detector of UV-Induced DNA Damage

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Part of the Advances in Intelligent Systems and Computing book series (AISC,volume 283)

Abstract

Maintaining the integrity of the DNA in the cell is essential for the proper functioning of the organism. For this purpose detection, amplification and transduction of the signal about DNA damage to the effector module is necessary. This results with cell cycle arrest, DNA repair or apoptosis. In some of the eukaryotic cells, like human, two modules play roles as DNA damage detectors: ATM (ataxia telangiectasia mutated), which responds to the formation of double DNA strand breaks and ATR (ataxia telangiectasia mutated and Rad3-related), which is responsible for detecting single-strand damage. Simulation analysis of a constructed mathematical model of ATR pathway is a subject of this study. Our results show that ATR is an effective system for damage detection and amplification of the signal. The activation of this module is fast: detection takes place within a few seconds after the occurrence of the damage. The created novel mathematical model explains the mechanism of single-strand breaks detection, enables testing of the impact of modifications of proteins belonging to the ATR-p53 signaling pathway. Additionally the model explains that the basic activation of p53 protein signaling pathway observed in cells, may be caused by persistent cellular stress levels.

Keywords

  • ATR
  • DNA
  • damage
  • detection
  • model
  • SSB

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  • DOI: 10.1007/978-3-319-06593-9_28
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Authors and Affiliations

  1. Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, Akademicka 16, 44-102, Gliwice, Poland

    Monika Kurpas, Katarzyna Jonak & Krzysztof Puszyński

Authors
  1. Monika Kurpas
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  2. Katarzyna Jonak
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  3. Krzysztof Puszyński
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Corresponding author

Correspondence to Monika Kurpas .

Editor information

Editors and Affiliations

  1. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Ewa Piętka

  2. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Jacek Kawa

  3. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Wojciech Wieclawek

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Kurpas, M., Jonak, K., Puszyński, K. (2014). Simulation Analysis of the ATR Module as a Detector of UV-Induced DNA Damage. In: Piętka, E., Kawa, J., Wieclawek, W. (eds) Information Technologies in Biomedicine, Volume 3. Advances in Intelligent Systems and Computing, vol 283. Springer, Cham. https://doi.org/10.1007/978-3-319-06593-9_28

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  • DOI: https://doi.org/10.1007/978-3-319-06593-9_28

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-06592-2

  • Online ISBN: 978-3-319-06593-9

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