Abstract
ABC transporters require a tight regulation of their transport activity as they often distribute substrates that are either toxic or of metabolic or developmental function. Moreover in contrast to secondary active transporters or channels they represent in energetic terms rather inefficient ATP-consuming nano-machines.
The regulation of mammalian ABC transporters has been deeply investigated in the last three decades because malfunction of many ABC transporters is causing socially and economically relevant diseases. However, despite their striking over-representation and their emerging important developmental and physiological function, surprisingly few is so far known on the regulation of plant ABCs. Therefore, in this chapter we have compared our recent knowledge on plant and non-plant ABC transporters in respect to their post-transcriptional regulation. Despite the limited information on plant ABC regulation it becomes more and more clear that many—if not all—regulatory mechanisms found for mammalian ABC transporters are also found in plants. We highlight in more detail some interesting examples on Arabidopsis ABCB regulation where plant research provided a deep and integrated understanding of ABC regulation that might serve as a blueprint for clinical research.
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Acknowledgments
The geislerLab is supported by funds of the University of Fribourg (Pool de Recherche), of the Novartis Foundation and the SNF. The author thanks Martin di Donato for critically reading the text.
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Geisler, M. (2014). It Takes More Than Two to Tango: Regulation of Plant ABC Transporters. In: Geisler, M. (eds) Plant ABC Transporters. Signaling and Communication in Plants, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-06511-3_13
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