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Umbilical Cord Blood Banking and Transplantation pp 269–275Cite as

Selection of the Optimal Cord Blood Unit

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Over 30,000 umbilical cord blood transplants have been performed since the first umbilical cord blood transplant in France in 1988. Outcomes have improved with a better understanding of the importance of cell dose and human leukocyte antigen (HLA) matching. The selection of the appropriate umbilical cord blood unit is more challenging than choosing bone marrow or peripheral blood stem cell donors. In this section, we review the data on cell dose and HLA typing, including high resolution typing, killer immunoglobulin receptor (KIR) matching, HLA C matching, and HLA antibodies. We also analyze the importance of cord blood banking factors, ABO match, and racial/ethnic matching. Finally, we discuss the challenges of the future in cord blood selection.

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Authors and Affiliations

  1. Leukemia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Karen K. Ballen MD

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  1. Karen K. Ballen MD
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Correspondence to Karen K. Ballen MD .

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  1. Leukemia Program, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Karen Ballen

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Ballen, K. (2014). Selection of the Optimal Cord Blood Unit. In: Ballen, K. (eds) Umbilical Cord Blood Banking and Transplantation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-06444-4_20

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