ARTE: An Embryo Quality Assessment Tool

  • João Silva
  • Paulo Fazendeiro
  • Fernando J. Prados Mondéjar
  • Soraia Pinto
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 276)


This paper proposes an assessment model of putative embryos for in vitro fertilization (IVF) based on a triangular norm. One of the most common difficulties of IVF treatments is multiple pregnancy. Therefore the number of embryos for transfer is of paramount importance considering the need to reduce the incidence of multiple births without compromising overall pregnancy rates in fertility treatments. Consequently the selective embryo transfer is recommended to optimize efficacy and safety outcomes. The embryo evaluation is of enormous relevance, since it directly affects the success of different techniques used in assisted reproductive technologies (ART). The gathering of all the information needed to embryo evaluation, as well as software that can serve as aid in the decision is of great importance. The tool herein presented accomplishes these two objectives. The analysis of the requirements of the assessment process has resulted in a flexible data model, used in the presented prototype, supporting the selective embryo transfer decision-making process.


Embryo Assessment Decision Making Software Engineering Assisted Reproductive Technologies 


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  1. 1.
    ART fact sheet, (retrieved from HYPERLINK)
  2. 2.
    Boivin, J., Bunting, L., et al.: International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Human Reproduction 22(6), 1506–1512Google Scholar
  3. 3.
    Rosa, P.: World Health Organization. Regional Office for Europe and International Children’s Center. Family health and family planning. Paris, International Children’s Centre, and Copenhagen, World Health Organization, Regional Office for Europe (1979)Google Scholar
  4. 4.
    Carvalho, J.L., Santos, A.: Estudo Afrodite – Caracterização da infertilidade em Portugal, (retrieved from HYPERLINK)
  5. 5.
    National (2011 - 2009) and European (2009 - 2007) reports of ART activities, (retrieved from HYPERLINK)
  6. 6.
    Sunde, A., Balaban, B.: The assisted reproductive technology laboratory: toward evidence-based practice? Fertility and Sterility 100(2), 310–318 (2013)CrossRefGoogle Scholar
  7. 7.
    Gardner, D., Weissman, A., Howles, C., Shoham, Z. (eds.): Textbook of Assisted Reproductive Techniques, 4th edn. Laboratory Perspectives, vol. 1. CRC Press (June 2012)Google Scholar
  8. 8.
    The IVF Informant: What is IVF? - Molly Robinson, (retrieved from HYPERLINK) (November 25, 2012)
  9. 9.
    The IVF Informant: What is ICSI? - The IVF Informant, (retrieved from HYPERLINK) (April 28, 2012)
  10. 10.
    The IVF Informant: Variations on IVF - GIFT and ZIFT - Molly Robinson, (retrieved from HYPERLINK) (November 27, 2012)
  11. 11.
    Bączkowski, T., Kurzawa, R., et al.: Methods of embryo scoring in in vitro fertilization. Reproductive Biology 4(1), 5–22 (2004), (retrieved from HYPERLINK)Google Scholar
  12. 12.
    ALPHA Scientists in Reproductiove Medicine and ESHRE Special Interest Group of Embriology: The Instambul Consensus workshop on embryo assessment: proceedings of a expert meeting. Human Reproduction, 1–14Google Scholar
  13. 13.
    Embryoscope® Time-Lapse System, (retrieved from HYPERLINK)
  14. 14.
    Embryoviewer® Software, (retrieved from HYPERLINK)
  15. 15.
    Giusti, A., Magli, M.C., et al.: Observing the 3-dimensional morphology of 4-cell embryos using computer analysis of image z-stacks. Human Reproduction 26(suppl. 1), i62–i63; Abstract Book of the 27th Eshre Annual Meeting – O158 Google Scholar
  16. 16.
    Artimis on Medialogic website - HYPERLINK,
  17. 17.
    Wathlet, S., Adriaenssens, T., et al.: New candidate genes to predict pregnancy outcome in single embryo transfer cycles when using cumulus cell gene expression. In: Fertility and Sterility (August 2012)Google Scholar
  18. 18.
    Stylianou, C., Critchlow, D., et al.: Embryo morphology as a predictor of IVF success: an evaluation of the proposed UK ACE grading scheme for cleavage stage embryos. In: Human Fertility, Cambridge, England (March 2012)Google Scholar
  19. 19.
    One at a time – better outcomes in fertility treatment, (retrieved from HYPERLINK)
  20. 20.
    Ardoy, M., Calderón, G., et al.: ASEBIR criteria for the morphological evaluation of human oocytes early embryos and blastocysts, 2nd edn., pp. 43–49Google Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • João Silva
    • 1
  • Paulo Fazendeiro
    • 1
  • Fernando J. Prados Mondéjar
    • 2
  • Soraia Pinto
    • 3
  1. 1.Instituto de Telecomunicações (IT), Department of InformaticsUniversity of Beira InteriorCovilhãPortugal
  2. 2.IVF LaboratoryHospital Madrid-MontepríncipeMadridSpain
  3. 3.Maternidade Doutor Alfredo da CostaLisboaPortugal

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