Abstract
A numerical study of analyte preconcentration by isotachophoresis is made. We have considered a 2-D model of isotachophoresis (ITP). Both peak and plateau mode of ITP are investigated in the present analysis. The Nernst–Planck equation is used for ion transport, electroneutrality condition for the electric field along with the Navier–Stokes equations for fluid flow. Our numerical algorithm is based on a finite volume method along with a higher-order upwind scheme. The present numerical method resolves efficiently the thin region (transition zone) between two adjacent analytes, in which either a step change (plateau mode) or a steep gradient (peak mode) of variables occur. Validity of the Kohlrausch’s regulating function (KRF) for the computed solution in peak-mode ITP is analyzed. The dynamics of ions in ITP is studied for a wide range of parameter values such as mobility, electric field, and amount of the sample. The dispersion of ITP due to nonuniform fluid convection is also studied.
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Gopmandal, P., Bhattacharyya, S. (2014). Numerical Study on Isotachophoretic Separation of Ionic Samples in Microfluidics. In: Basu, S., Kumar, N. (eds) Modelling and Simulation of Diffusive Processes. Simulation Foundations, Methods and Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-05657-9_5
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DOI: https://doi.org/10.1007/978-3-319-05657-9_5
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