Abstract
A collection of studies over the past decade has brought about a shift in how we understand the interaction between the therapeutic killing of cancer cells and the host antitumour immune response. Rather than a tolerogenic or zero-impact event, the induced death of cancer cells has been shown under certain conditions and circumstances to actually incite an immune response against dead cancer cell antigens. This phenomenon is referred to as ‘immunogenic cell death (ICD)’, which has been strongly associated with the actions and therapeutic value of certain antineoplastic agents. In itself, ICD induced by such agents has challenged the theory that these therapies simply kill or target proliferation of malignant cells in a cell-autonomous disease. The evidence presented in this chapter points towards an additional aspect to cytotoxic cancer therapies, in that they also induce (or reinstate) an extrinsic control exerted by the host immune system. We will discuss how a precise combination of molecular cues and metabolic variations is induced through ICD to form a key, with the ability to ‘unlock’ an otherwise restrained immune response against the cancer.
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This chapter is dedicated to an exemplary scientist, a pioneering immunotherapist and a long-standing friend, Christoph Huber.
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Pitt, J.M., Vetizou, M., Kepp, O., Kroemer, G., Zitvogel, L. (2014). Molecular and Metabolic Cues of the Key-Lock Paradigm Dictating Immunogenic Cell Death. In: Britten, C., Kreiter, S., Diken, M., Rammensee, HG. (eds) Cancer Immunotherapy Meets Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-05104-8_20
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