Skip to main content

Does Photosensitivity Exist in Focal Epilepsy?

Part III. Clinical Perspective

  • Chapter
  • First Online:
The Importance of Photosensitivity for Epilepsy
  • 583 Accesses

Abstract

Photosensitivity is denoted as an abnormal clinical and/or electroencephalographic (EEG) response to visual stimuli and can be proven in EEG laboratory using intermittent photic stimulation (IPS). The epileptiform EEG discharges evoked by Intermittent Photic Stimulation (IPS) are called photoparoxysmal response (PPR) and according to internationally accepted classification, there are four types of PPR where Type 1 and Type 2 are considered focal and Type 3 and 4 generalized PPR.

In the past two decades, publications have shown that photosensitivity is not exclusively related to generalized epilepsy and emphasis has especially been placed on photosensitivity in focal epilepsies such as idiopathic photosensitive occipital lobe epilepsy (IPOE/IPOLE), idiopathic occipital lobe epilepsy with late onset (Gastaut type), and benign childhood epilepsy with centrotemporal spikes (BCECTS, BRE, Rolandic epilepsy).

This chapter will discuss photosensitivity in different focal epilepsy syndromes and focal epilepsies along with instructive EEG samples.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Yalcin AD, Kaymaz A, Forta H. Reflex occipital lobe epilepsy. Seizure. 2000;9:436–41.

    Article  CAS  PubMed  Google Scholar 

  2. Zifkin BG, Kasteleijn-Nolst-Trenité DGA. Reflex epilepsy and reflex seizures of the visual system: a clinical review. Epil Disord. 2000;2:129–36.

    CAS  Google Scholar 

  3. Kasteleijn-Nolst Trenité DGA. Photosensitivity in epilepsy. Electrophysiological and clinical correlates. Acta Neurol Scand. 1989;80(S125):3–149.

    Google Scholar 

  4. Kasteleijn-Nolst Trenité DGA, Guerrini R, Binnie CD, Genton P. Visual sensitivity and epilepsy: a proposed terminology and classification for clinical and EEG phenomenology. Epilepsia. 2000;42(Suppl. 5):692–701.

    Google Scholar 

  5. Waltz S, Christen H-J, Doose H. The different patterns of the photoparoxysmal response—a genetic study. Electroencephalogr Clin Neurophysiol. 1992;83:138–45.

    Article  CAS  PubMed  Google Scholar 

  6. Wolf P, Goosses R. Relation of photosensitivity to epileptic syndromes. J Neurol Neurosurg Psychiatry. 1986;49:1386–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Danesi MA, Oni K. Photosensitive epilepsy and photoconvulsive responses to photic stimulation in Africans. Epilepsia. 1983;24(4):455–8.

    Article  CAS  PubMed  Google Scholar 

  8. Lu Y, Waltz S, Stenzel K, Muhle H, Stephani U. Photosensitivity in epileptic syndromes of childhood and adolescence. Epileptic Disord. 2008;10(2):136–43.

    PubMed  Google Scholar 

  9. Jeavons PM, Harding GFA. Photosensitive epilepsy. London: William Heinemann Medical Books; 1975.

    Google Scholar 

  10. Ricci S, Vigevano F. Occipital seizures provoked by intermittent light stimulation: ictal and interictal findings. J Clin Neurophysiol. 1993;10:197–20.

    Article  CAS  PubMed  Google Scholar 

  11. Guerrini R, Bonanni P, Parmeggiani L, Thomas P, Mattia D, Harvey AS, Duchowny MS. Induction of partial seizures by visual stimulation. Clinical and electroencephalographic features and evoked potential studies. Adv Neurol. 1998;75:159–78.

    CAS  PubMed  Google Scholar 

  12. Takada H, Aso K, Watanabe K, Okumura A, Negoro T, Ishikawa T. Epileptic seizures induced by animated cartoon, pocket monster. Epilepsia. 1999;40(7):997–1002.

    Article  CAS  PubMed  Google Scholar 

  13. Ferrie CD, De Marco P, Grunewald RA, Giannakodimos S, Panayiotopoulos CP. Video game induced seizures. J Neurol Neurosurg Psychiatry. 1994;57:925–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hennessy MJ, Binnie CD. Photogenic partial seizures. Epilepsia. 2000;41(1):59–64.

    Article  CAS  PubMed  Google Scholar 

  15. Whitehead K, Sherratt M, Kandler R, Lawrence S, Pang C. Photic stimulation during electroencephalography: efficacy and safety in an unselected cohort of patients referred to UK neurophysiology departments. Seizure. 2016;4:29–34.

    Article  Google Scholar 

  16. Koutroumanidis M, Tsirka V, Panayiotopoulos CP. Adult-onset photosensitivity: clinical significance and epilepsy syndromes including idiopathic (possibly genetic) photosensitive occipital epilepsy. Epileptic Disord. 2015;17(3):275–86.

    Article  PubMed  Google Scholar 

  17. Kasteleijn-Nolst Trenite DGA, Genton P, Brandt C, Reed R. The “photosensitivity model” is (also) a model for focal (partial) seizures. Epilepsy Res. 2017;133:113–20.

    Article  PubMed  Google Scholar 

  18. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389–99.

    Article  Google Scholar 

  19. Engel J Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001;42:796–803.

    Article  PubMed  Google Scholar 

  20. Guerrini R, Dravet C, Genton P, Bureau M, Bonanni P, Ferrari AR, Roger J. Idiopathic photosensitive occipital lobe epilepsy. Epilepsia. 1995;36:883–91.

    Article  CAS  PubMed  Google Scholar 

  21. Adcock JA, Panayiotopoulos CP. Occipital lobe seizures and epilepsies. J Clin Neurophysiol. 2012;29(5):397–407.

    Article  PubMed  Google Scholar 

  22. Guerrini R, Ferrari AR, Battaglia A, Salvadori P, Bonanni P. Occipitotemporal seizures with ictus emeticus induced by intermittent photic stimulation. Neurology. 1994;44:253–9.

    Article  CAS  PubMed  Google Scholar 

  23. Panayiotopoulos CP. Benign childhood epilepsy with occipital paroxysms: a 15-year prospective study. Ann Neurol. 1989;26(1):51–6.

    Article  CAS  PubMed  Google Scholar 

  24. Jacome DE, FitzGerald R. Ictus emeticus. Neurology. 1982;32:209–12.

    Article  CAS  PubMed  Google Scholar 

  25. Kramer RE, Luders H, Goldstick LP, Dinner DS, Morris HH, Lesser RP, Wyllie E. Ictus emeticus: an electroclinical analysis. Neurology. 1988;38:1048–52.

    Article  CAS  PubMed  Google Scholar 

  26. Penfield W, Faulk ME. The insula. Further observations on its function. Brain. 1955;78:445–70.

    Article  CAS  PubMed  Google Scholar 

  27. Aso K, Watanabe K, Negoro T, Takaesu E, Furune A, Takahashi I, Yamamoto N, Nomura K. Visual seizures in children. Epilepsy Res. 1987;1:246–53.

    Article  CAS  PubMed  Google Scholar 

  28. Young B, Blume WT. Painful epileptic seizures. Brain. 1983;116:537–54.

    Article  Google Scholar 

  29. Aso K, Watanabe K, Negoro T, Furune A, Takahashi I, Yamamoto N, Nomura K. Photosensitive partial seizure: the origin of abnormal discharges. J Epilepsy. 1988;1:87–93.

    Article  Google Scholar 

  30. Maeda Y, Kurokawa T, Sakamoto K, Kitamoto I, Ueda K, Tashima S. Electroclinical study of video-game epilepsy. Dev Med Child Neurol. 1990;32:493–500.

    Article  CAS  PubMed  Google Scholar 

  31. Bonini F, Egeo G, Fattouch J, Fanella M, Morano A, Giallonardo AT, di Bonaventura C. Natural evolution from idiopathic photosensitive occipital lobe epilepsy to idiopathic generalized epilepsy in an untreated young patient. Brain Dev. 2014;36:346–50.

    Article  PubMed  Google Scholar 

  32. Guerrini R, Bonanni P, Parmeggiani L, Belmonte A. Adolescent onset of idiopathic photosensitive occipital epilepsy after remission of benign rolandic epilepsy. Epilepsia. 1997;38(7):777–81.

    Article  CAS  PubMed  Google Scholar 

  33. Taylor I, Marini C, Johnson MR, Turner S, Berkovic SF, Scheffer IE. Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap? Brain. 2004;127(8):1878–86.

    Article  PubMed  Google Scholar 

  34. Panayiotopoulos CP. Clinical guide to epileptic syndrome and their treatment, Revised 2nd ed. London: Springer Healthcare Ltd; 2010. p. 347–75.

    Google Scholar 

  35. Chadwick DW. Valproate monotherapy in the management of generalized and partial seizures. Epilepsia. 1987;28(Suppl 2):S12–7.

    Article  PubMed  Google Scholar 

  36. Engel J Jr. Report of the ILAE classification core group. Epilepsia. 2006;47:1558–68.

    Article  PubMed  Google Scholar 

  37. Fallah A, Ramachandran NR. Does photoparoxysmal response in children represent provoked seizure? Evidence from simultaneous motor task during EEG. Clin Neurol Neurosurg. 2009;111:147–50.

    Article  PubMed  Google Scholar 

  38. Gilliam FG, Chiappa KH. Significance of spontaneous epileptiform abnormalities associated with a photoparoxysmal response. Neurology. 1995;4:453–6.

    Article  Google Scholar 

  39. Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics. 2006;118:e1237–43.

    Article  PubMed  Google Scholar 

  40. Ferrie CD, Grunewald RA. Panayiotopoulos syndrome: a common and benign childhood epilepsy. Lancet. 2001;357:821–3.

    Article  CAS  PubMed  Google Scholar 

  41. Koutroumanidis M. Panayiotopoulos syndrome: a common benign but underdiagnosed and unexplored early childhood seizure syndrome. BMJ. 2002;324:1228–9.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Panayiotopoulos CP. The birth and evolution of the concept of Panayiotopoulos syndrome. Epilepsia. 2007;48:1041–3.

    Article  PubMed  Google Scholar 

  43. Caraballo R, Cersosimo R, Fejerman N. Panayiotopoulos syndrome: a prospective study of 192 patients. Epilepsia. 2007;48:1054–61.

    Article  PubMed  Google Scholar 

  44. Panayiotopoulos CP. Occipital spikes, occipital paroxysms and other electroencephalographic findings in children with benign childhood occipital seizures. Occipital spikes in normal children and those without seizures. In: Panayiotopoulos CP, editor. Benign childhood partial seizures and related epileptic syndromes. London: John Libbey & Co. Ltd; 1999. p. 173–202.

    Google Scholar 

  45. Kivity S, Ephraim T, Weitz R, Tamir A. Childhood epilepsy with occipital paroxysms: clinical variants in 134 patients. Epilepsia. 2000;41(12):1522–33.

    Article  CAS  PubMed  Google Scholar 

  46. Caraballo RH, Koutroumanidis M, Panayiotopoulos CP, Fejerman N. Idiopathic childhood occipital epilepsy of Gastaut. J Child Neurol. 2009;24(12):1536–42.

    Article  PubMed  Google Scholar 

  47. Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain. 2008;131:2264–86.

    Article  PubMed  Google Scholar 

  48. Caraballo RH, Sologuestua A, Granana N, Adi JN, Cersosimo R, Mazza E, Foster O, Fejerman N. Idiopathic occipital and absence epilepsies appearing in the same children. Ped Neur. 2004;30(1):24–8.

    Article  Google Scholar 

  49. Politi-Elishkevich K, Kivity S, Shuper A, Levine H, Goldberg-Stern H. Idiopathic photosensitive occipital epilepsy: clinical and electroencephalographic (EEG) features. J Child Neurol. 2014;29(3):307–11.

    Article  PubMed  Google Scholar 

  50. Panayiotopoulos CP. Inhibitory effect of central vision on occipital lobe seizures. Neurology. 1981;31:1330–3.

    Article  CAS  PubMed  Google Scholar 

  51. Panayiotopoulos CP. Fixation-off, scotosensitive, and other visual-related epilepsies. Adv Neurol. 1998;75:139–57.

    CAS  PubMed  Google Scholar 

  52. Ogura K, Maegaki Y, Koeda T. EEG evaluation of fixation off sensitivity in eyelid myoclonia with absences. Pediatr Neurol. 2005;33:142–5.

    Article  PubMed  Google Scholar 

  53. Panayiotopoulos CP. Fixation-off-sensitive epilepsy in eyelid myoclonia with absence seizures. Ann Neurol. 1987;22:87–9.

    Article  CAS  PubMed  Google Scholar 

  54. Maher J, Ronen GM, Ogunyemi AO, Goulden KJ. Occipital paroxysmal discharges suppressed by eye opening: variability in clinical and seizure manifestations in childhood. Epilepsia. 1995;36:52–7.

    Article  CAS  PubMed  Google Scholar 

  55. Newton R, Aicardi J. Clinical findings in children with occipital spike-wave complexes suppressed by eye-opening. Neurology. 1983;33:1526–9.

    Article  CAS  PubMed  Google Scholar 

  56. Kurth C, Bittermann HJ, Wegerer V, Bleich S, Steinhoff BJ. Fixation-off sensitivity in an adult with symptomatic occipital epilepsy. Epilepsia. 2001;42:947–9.

    Article  CAS  PubMed  Google Scholar 

  57. Nicolai J, Vles JS, van Tellingen V, van Kranen-Mastenbroek VH. Inverted fixation-off sensitivity in atypical benign partial epilepsy. Pediatr Neurol. 2008;38(4):279–83.

    Article  PubMed  Google Scholar 

  58. Kumada S, Kubota M, Hayashi M, Uchiyama A, Kurata K, Kagamihara Y. Fixation-sensitive myoclonus in Lafora disease. Neurology. 2006;66:1574–6.

    Article  CAS  PubMed  Google Scholar 

  59. Saadeldin IY, Matlik HN. Coexistence of fixation-off sensitivity and inverted fixation-off sensitivity in a female child with Panayiotopoulos syndrome: video-electroencephalography documentation. Epilepsy Behav Case Rep. 2015;28(4):1–5.

    Google Scholar 

  60. Baykan-Kurt B, Gökyiğit A, Parman Y, Kinay D, Gürsus C. Eye closure related spike and wave discharges: clinical and syndromic associations. Clin Electroencephalogr. 1999;30:106–10.

    Article  CAS  PubMed  Google Scholar 

  61. Senbil N, Soyer O, Turanlý G, Gürer YK. Fixation-off sensitivity and generalized epileptic EEG induced by eyes closed. Pediatr Neurol. 2006;35:363–6.

    Article  PubMed  Google Scholar 

  62. Benbadis SR, Gerson WA, Harvey JH, Lüders HO. Photosensitive temporal lobe epilepsy. Neurology. 1996;46(6):1540–2.

    Article  CAS  PubMed  Google Scholar 

  63. Inoue K, Mimori Y, Harada T, Oshita T, Kumagai R, Nakamura S. The relationship between photosensitive temporal lobe epilepsy and eye closure activity. Seizure. 2000;9(5):347–51.

    Article  CAS  PubMed  Google Scholar 

  64. Lee CY, Jeon JY, Cho YW, Moon HJ. A case of temporal onset partial seizure induced by photic stimuli. J Epilepsy Res. 2014;30(1):18–20.

    Article  Google Scholar 

  65. Seddigh S, Thömke F, Vogt TH. Complex partial seizures provoked by photic stimulation. J Neurol Neurosurg Psychiatry. 1999;66(6):801–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bosanka Jocic-Jakubi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jocic-Jakubi, B. (2021). Does Photosensitivity Exist in Focal Epilepsy?. In: Kasteleijn-Nolst Trenite, D. (eds) The Importance of Photosensitivity for Epilepsy. Springer, Cham. https://doi.org/10.1007/978-3-319-05080-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-05080-5_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-05079-9

  • Online ISBN: 978-3-319-05080-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics