Abstract
Photosensitivity is denoted as an abnormal clinical and/or electroencephalographic (EEG) response to visual stimuli and can be proven in EEG laboratory using intermittent photic stimulation (IPS). The epileptiform EEG discharges evoked by Intermittent Photic Stimulation (IPS) are called photoparoxysmal response (PPR) and according to internationally accepted classification, there are four types of PPR where Type 1 and Type 2 are considered focal and Type 3 and 4 generalized PPR.
In the past two decades, publications have shown that photosensitivity is not exclusively related to generalized epilepsy and emphasis has especially been placed on photosensitivity in focal epilepsies such as idiopathic photosensitive occipital lobe epilepsy (IPOE/IPOLE), idiopathic occipital lobe epilepsy with late onset (Gastaut type), and benign childhood epilepsy with centrotemporal spikes (BCECTS, BRE, Rolandic epilepsy).
This chapter will discuss photosensitivity in different focal epilepsy syndromes and focal epilepsies along with instructive EEG samples.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Yalcin AD, Kaymaz A, Forta H. Reflex occipital lobe epilepsy. Seizure. 2000;9:436–41.
Zifkin BG, Kasteleijn-Nolst-Trenité DGA. Reflex epilepsy and reflex seizures of the visual system: a clinical review. Epil Disord. 2000;2:129–36.
Kasteleijn-Nolst Trenité DGA. Photosensitivity in epilepsy. Electrophysiological and clinical correlates. Acta Neurol Scand. 1989;80(S125):3–149.
Kasteleijn-Nolst Trenité DGA, Guerrini R, Binnie CD, Genton P. Visual sensitivity and epilepsy: a proposed terminology and classification for clinical and EEG phenomenology. Epilepsia. 2000;42(Suppl. 5):692–701.
Waltz S, Christen H-J, Doose H. The different patterns of the photoparoxysmal response—a genetic study. Electroencephalogr Clin Neurophysiol. 1992;83:138–45.
Wolf P, Goosses R. Relation of photosensitivity to epileptic syndromes. J Neurol Neurosurg Psychiatry. 1986;49:1386–91.
Danesi MA, Oni K. Photosensitive epilepsy and photoconvulsive responses to photic stimulation in Africans. Epilepsia. 1983;24(4):455–8.
Lu Y, Waltz S, Stenzel K, Muhle H, Stephani U. Photosensitivity in epileptic syndromes of childhood and adolescence. Epileptic Disord. 2008;10(2):136–43.
Jeavons PM, Harding GFA. Photosensitive epilepsy. London: William Heinemann Medical Books; 1975.
Ricci S, Vigevano F. Occipital seizures provoked by intermittent light stimulation: ictal and interictal findings. J Clin Neurophysiol. 1993;10:197–20.
Guerrini R, Bonanni P, Parmeggiani L, Thomas P, Mattia D, Harvey AS, Duchowny MS. Induction of partial seizures by visual stimulation. Clinical and electroencephalographic features and evoked potential studies. Adv Neurol. 1998;75:159–78.
Takada H, Aso K, Watanabe K, Okumura A, Negoro T, Ishikawa T. Epileptic seizures induced by animated cartoon, pocket monster. Epilepsia. 1999;40(7):997–1002.
Ferrie CD, De Marco P, Grunewald RA, Giannakodimos S, Panayiotopoulos CP. Video game induced seizures. J Neurol Neurosurg Psychiatry. 1994;57:925–31.
Hennessy MJ, Binnie CD. Photogenic partial seizures. Epilepsia. 2000;41(1):59–64.
Whitehead K, Sherratt M, Kandler R, Lawrence S, Pang C. Photic stimulation during electroencephalography: efficacy and safety in an unselected cohort of patients referred to UK neurophysiology departments. Seizure. 2016;4:29–34.
Koutroumanidis M, Tsirka V, Panayiotopoulos CP. Adult-onset photosensitivity: clinical significance and epilepsy syndromes including idiopathic (possibly genetic) photosensitive occipital epilepsy. Epileptic Disord. 2015;17(3):275–86.
Kasteleijn-Nolst Trenite DGA, Genton P, Brandt C, Reed R. The “photosensitivity model” is (also) a model for focal (partial) seizures. Epilepsy Res. 2017;133:113–20.
Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389–99.
Engel J Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001;42:796–803.
Guerrini R, Dravet C, Genton P, Bureau M, Bonanni P, Ferrari AR, Roger J. Idiopathic photosensitive occipital lobe epilepsy. Epilepsia. 1995;36:883–91.
Adcock JA, Panayiotopoulos CP. Occipital lobe seizures and epilepsies. J Clin Neurophysiol. 2012;29(5):397–407.
Guerrini R, Ferrari AR, Battaglia A, Salvadori P, Bonanni P. Occipitotemporal seizures with ictus emeticus induced by intermittent photic stimulation. Neurology. 1994;44:253–9.
Panayiotopoulos CP. Benign childhood epilepsy with occipital paroxysms: a 15-year prospective study. Ann Neurol. 1989;26(1):51–6.
Jacome DE, FitzGerald R. Ictus emeticus. Neurology. 1982;32:209–12.
Kramer RE, Luders H, Goldstick LP, Dinner DS, Morris HH, Lesser RP, Wyllie E. Ictus emeticus: an electroclinical analysis. Neurology. 1988;38:1048–52.
Penfield W, Faulk ME. The insula. Further observations on its function. Brain. 1955;78:445–70.
Aso K, Watanabe K, Negoro T, Takaesu E, Furune A, Takahashi I, Yamamoto N, Nomura K. Visual seizures in children. Epilepsy Res. 1987;1:246–53.
Young B, Blume WT. Painful epileptic seizures. Brain. 1983;116:537–54.
Aso K, Watanabe K, Negoro T, Furune A, Takahashi I, Yamamoto N, Nomura K. Photosensitive partial seizure: the origin of abnormal discharges. J Epilepsy. 1988;1:87–93.
Maeda Y, Kurokawa T, Sakamoto K, Kitamoto I, Ueda K, Tashima S. Electroclinical study of video-game epilepsy. Dev Med Child Neurol. 1990;32:493–500.
Bonini F, Egeo G, Fattouch J, Fanella M, Morano A, Giallonardo AT, di Bonaventura C. Natural evolution from idiopathic photosensitive occipital lobe epilepsy to idiopathic generalized epilepsy in an untreated young patient. Brain Dev. 2014;36:346–50.
Guerrini R, Bonanni P, Parmeggiani L, Belmonte A. Adolescent onset of idiopathic photosensitive occipital epilepsy after remission of benign rolandic epilepsy. Epilepsia. 1997;38(7):777–81.
Taylor I, Marini C, Johnson MR, Turner S, Berkovic SF, Scheffer IE. Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap? Brain. 2004;127(8):1878–86.
Panayiotopoulos CP. Clinical guide to epileptic syndrome and their treatment, Revised 2nd ed. London: Springer Healthcare Ltd; 2010. p. 347–75.
Chadwick DW. Valproate monotherapy in the management of generalized and partial seizures. Epilepsia. 1987;28(Suppl 2):S12–7.
Engel J Jr. Report of the ILAE classification core group. Epilepsia. 2006;47:1558–68.
Fallah A, Ramachandran NR. Does photoparoxysmal response in children represent provoked seizure? Evidence from simultaneous motor task during EEG. Clin Neurol Neurosurg. 2009;111:147–50.
Gilliam FG, Chiappa KH. Significance of spontaneous epileptiform abnormalities associated with a photoparoxysmal response. Neurology. 1995;4:453–6.
Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics. 2006;118:e1237–43.
Ferrie CD, Grunewald RA. Panayiotopoulos syndrome: a common and benign childhood epilepsy. Lancet. 2001;357:821–3.
Koutroumanidis M. Panayiotopoulos syndrome: a common benign but underdiagnosed and unexplored early childhood seizure syndrome. BMJ. 2002;324:1228–9.
Panayiotopoulos CP. The birth and evolution of the concept of Panayiotopoulos syndrome. Epilepsia. 2007;48:1041–3.
Caraballo R, Cersosimo R, Fejerman N. Panayiotopoulos syndrome: a prospective study of 192 patients. Epilepsia. 2007;48:1054–61.
Panayiotopoulos CP. Occipital spikes, occipital paroxysms and other electroencephalographic findings in children with benign childhood occipital seizures. Occipital spikes in normal children and those without seizures. In: Panayiotopoulos CP, editor. Benign childhood partial seizures and related epileptic syndromes. London: John Libbey & Co. Ltd; 1999. p. 173–202.
Kivity S, Ephraim T, Weitz R, Tamir A. Childhood epilepsy with occipital paroxysms: clinical variants in 134 patients. Epilepsia. 2000;41(12):1522–33.
Caraballo RH, Koutroumanidis M, Panayiotopoulos CP, Fejerman N. Idiopathic childhood occipital epilepsy of Gastaut. J Child Neurol. 2009;24(12):1536–42.
Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain. 2008;131:2264–86.
Caraballo RH, Sologuestua A, Granana N, Adi JN, Cersosimo R, Mazza E, Foster O, Fejerman N. Idiopathic occipital and absence epilepsies appearing in the same children. Ped Neur. 2004;30(1):24–8.
Politi-Elishkevich K, Kivity S, Shuper A, Levine H, Goldberg-Stern H. Idiopathic photosensitive occipital epilepsy: clinical and electroencephalographic (EEG) features. J Child Neurol. 2014;29(3):307–11.
Panayiotopoulos CP. Inhibitory effect of central vision on occipital lobe seizures. Neurology. 1981;31:1330–3.
Panayiotopoulos CP. Fixation-off, scotosensitive, and other visual-related epilepsies. Adv Neurol. 1998;75:139–57.
Ogura K, Maegaki Y, Koeda T. EEG evaluation of fixation off sensitivity in eyelid myoclonia with absences. Pediatr Neurol. 2005;33:142–5.
Panayiotopoulos CP. Fixation-off-sensitive epilepsy in eyelid myoclonia with absence seizures. Ann Neurol. 1987;22:87–9.
Maher J, Ronen GM, Ogunyemi AO, Goulden KJ. Occipital paroxysmal discharges suppressed by eye opening: variability in clinical and seizure manifestations in childhood. Epilepsia. 1995;36:52–7.
Newton R, Aicardi J. Clinical findings in children with occipital spike-wave complexes suppressed by eye-opening. Neurology. 1983;33:1526–9.
Kurth C, Bittermann HJ, Wegerer V, Bleich S, Steinhoff BJ. Fixation-off sensitivity in an adult with symptomatic occipital epilepsy. Epilepsia. 2001;42:947–9.
Nicolai J, Vles JS, van Tellingen V, van Kranen-Mastenbroek VH. Inverted fixation-off sensitivity in atypical benign partial epilepsy. Pediatr Neurol. 2008;38(4):279–83.
Kumada S, Kubota M, Hayashi M, Uchiyama A, Kurata K, Kagamihara Y. Fixation-sensitive myoclonus in Lafora disease. Neurology. 2006;66:1574–6.
Saadeldin IY, Matlik HN. Coexistence of fixation-off sensitivity and inverted fixation-off sensitivity in a female child with Panayiotopoulos syndrome: video-electroencephalography documentation. Epilepsy Behav Case Rep. 2015;28(4):1–5.
Baykan-Kurt B, Gökyiğit A, Parman Y, Kinay D, Gürsus C. Eye closure related spike and wave discharges: clinical and syndromic associations. Clin Electroencephalogr. 1999;30:106–10.
Senbil N, Soyer O, Turanlý G, Gürer YK. Fixation-off sensitivity and generalized epileptic EEG induced by eyes closed. Pediatr Neurol. 2006;35:363–6.
Benbadis SR, Gerson WA, Harvey JH, Lüders HO. Photosensitive temporal lobe epilepsy. Neurology. 1996;46(6):1540–2.
Inoue K, Mimori Y, Harada T, Oshita T, Kumagai R, Nakamura S. The relationship between photosensitive temporal lobe epilepsy and eye closure activity. Seizure. 2000;9(5):347–51.
Lee CY, Jeon JY, Cho YW, Moon HJ. A case of temporal onset partial seizure induced by photic stimuli. J Epilepsy Res. 2014;30(1):18–20.
Seddigh S, Thömke F, Vogt TH. Complex partial seizures provoked by photic stimulation. J Neurol Neurosurg Psychiatry. 1999;66(6):801–2.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Jocic-Jakubi, B. (2021). Does Photosensitivity Exist in Focal Epilepsy?. In: Kasteleijn-Nolst Trenite, D. (eds) The Importance of Photosensitivity for Epilepsy. Springer, Cham. https://doi.org/10.1007/978-3-319-05080-5_11
Download citation
DOI: https://doi.org/10.1007/978-3-319-05080-5_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-05079-9
Online ISBN: 978-3-319-05080-5
eBook Packages: MedicineMedicine (R0)