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The Penumbra Coil 400 System for Treatment of Wide-Necked Intracranial Aneurysms: Initial Single-Center Experience

Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA,volume 120)


Endovascular treatment of wide-necked intracranial aneurysms frequently requires stent- or balloon-assisted coiling to prevent coil herniation into the parent artery. Provided that coils can be securely deployed within the aneurysm sac, these adjunctive devices and their associated risk can be avoided. The Penumbra 400 Coil (PC-400) has a larger diameter than conventional coils and is constructed completely of metal, a feature that increases the coil stability and may improve its ability to respect the aneurysm neck. The purpose of this study was to examine the frequency of adjunctive stent usage when coiling wide-necked intracranial aneurysms with the PC-400 in comparison with conventional coils. We examined consecutive patients with unruptured wide-necked aneurysms treated at our institution with endovascular coils. Aneurysm characteristics and procedural outcomes were compared between patients treated with PC-400 compared with a control group treated with conventional coils. Thirty-eight patients met criteria for this study. Stent-assisted coiling was required in 34 % fewer cases using PC-400 compared with conventional coils (P = .049). Fewer coils and less length were required with the PC-400 to obtain the same packing densities, occlusion types, and short-term stability. This may reduce treatment cost and prove to be valuable in patients with contraindications to dual antiplatelet therapy.


  • Intracranial aneurysm
  • Embolization
  • Penumbra Coil 400
  • Stent-assisted coiling
  • Wide necked

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Conflict of Interest Statement

Dr. Eric Deshaies consults for MicroVention Inc., Covidien Neurovascular, Integra LifeSciences Corporation, and McKesson Health Solutions.

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Correspondence to Eric M. Deshaies MD .

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Villwock, M.R., Singla, A., Padalino, D.J., Deshaies, E.M. (2015). The Penumbra Coil 400 System for Treatment of Wide-Necked Intracranial Aneurysms: Initial Single-Center Experience. In: Fandino, J., Marbacher, S., Fathi, AR., Muroi, C., Keller, E. (eds) Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 120. Springer, Cham.

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