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Tenascin-C Is a Possible Mediator Between Initial Brain Injury and Vasospasm-Related and -Unrelated Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

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Neurovascular Events After Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 120))

Abstract

Introduction: Tenascin-C (TNC), a matricellular protein, exerts diverse functions, including tissue remodeling and apoptosis, and is induced in cerebrospinal fluid (CSF) after aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationships among CSF TNC levels, initial brain injury, delayed cerebral ischemia (DCI), and vasospasm after SAH.

Methods: CSF TNC levels were measured in 30 patients with aneurysmal SAH of Fisher computed tomography (CT) group III who were treated microsurgically or endovascularly with CSF drainage within 24 h of SAH. Admission World Federation of Neurosurgical Societies (WFNS) grade was supposed to indicate the severity of initial brain injury. Cerebral vasospasm was defined as narrowed (≥25 %) cerebral arteries demonstrated by angiography. DCI was defined as any neurological deterioration presumed related to ischemia that persisted for ≥1 h.

Results: Higher CSF TNC levels were correlated with worse admission WFNS grades. Vasospasm was aggravated with higher TNC levels. DCI occurred regardless of the degree of vasospasm but was associated with TNC induction. Multivariate analyses showed that higher TNC levels and vasospasm were independent predictors of DCI occurrence.

Conclusions: SAH (initial brain injury) that is more severe induces more TNC, which may cause the subsequent development of both vasospasm and vasospasm-unrelated secondary brain injury, leading to DCI.

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Acknowledgments and Funding

This work was supported in part by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science and Mie Society for the Promotion of Medical Research to Dr. Suzuki.

Conflict of Interest Statement

 We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Hidenori Suzuki MD, PhD, Masato Shiba MD, PhD, Masashi Fujimoto MD, PhD, Fumio Kawakita MD & Waro Taki MD, PhD

  2. Research Center for Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Hidenori Suzuki MD, PhD, Kyoko Imanaka-Yoshida MD, PhD & Toshimichi Yoshida MD, PhD

  3. Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka, Japan

    Kenji Kanamaru MD, PhD

  4. Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Kyoko Imanaka-Yoshida MD, PhD & Toshimichi Yoshida MD, PhD

Authors
  1. Hidenori Suzuki MD, PhD
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  2. Kenji Kanamaru MD, PhD
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  3. Masato Shiba MD, PhD
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  4. Masashi Fujimoto MD, PhD
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  5. Fumio Kawakita MD
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  6. Kyoko Imanaka-Yoshida MD, PhD
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  7. Toshimichi Yoshida MD, PhD
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  8. Waro Taki MD, PhD
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Corresponding author

Correspondence to Hidenori Suzuki MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Javier Fandino

  2. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Serge Marbacher

  3. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Ali-Reza Fathi

  4. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland

    Carl Muroi

  5. Department of Neurosurgery Neurointensive Care Unit, University Hospital Zurich, Zurich, Switzerland

    Emanuela Keller

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© 2015 Springer International Publishing Switzerland

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Suzuki, H. et al. (2015). Tenascin-C Is a Possible Mediator Between Initial Brain Injury and Vasospasm-Related and -Unrelated Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. In: Fandino, J., Marbacher, S., Fathi, AR., Muroi, C., Keller, E. (eds) Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 120. Springer, Cham. https://doi.org/10.1007/978-3-319-04981-6_20

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  • DOI: https://doi.org/10.1007/978-3-319-04981-6_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-04980-9

  • Online ISBN: 978-3-319-04981-6

  • eBook Packages: MedicineMedicine (R0)

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