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Fluorinated Pyrazoles and Indazoles

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Book cover Fluorine in Heterocyclic Chemistry Volume 1

Abstract

The synthesis of fluorine containing pyrazoles has been boosted in the past decades due to the interesting properties that confer these building blocks in pharmaceutical and agricultural active ingredients. There are two main methods for the synthesis of fluorine-containing organic compounds, namely, the direct replacement of an atom or functional group such as diazo, hydroxyl, halogen or hydrogen by fluorine, and the modification of fluorine-containing building blocks. In the case of fluorinated pyrazoles the latter approach is the most commonly applied. This chapter deals primarily with the pivotal procedures that allow the preparation of fluoro- and fluoroalkyl- pyrazoles. Their benzocondensed derivatives, indazoles, have been studied to a much lesser extent. The fundamental applications of this class of compounds in different fields are also discussed.

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Acknowledgments

We would like to thank MICINN (CTQ2010-19774) of Spain and Generalitat Valenciana (PROMETEO/2010/061) for their financial support.

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Authors and Affiliations

  1. Departamento de Química Orgánica, Universidad de Valencia, E-46100, Burjassot, Spain

    Santos Fustero, Antonio Simón-Fuentes & Raquel Román

  2. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, E-46012, Valencia, Spain

    Santos Fustero

  3. Neuroscience Medicinal Chemistry Department, Janssen Research and Development, E-45007, Toledo, Spain

    Oscar Delgado

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  1. Santos Fustero
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Correspondence to Santos Fustero .

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  1. Department of Chemistry, Moscow State University, Moscow, Russia

    Valentine Nenajdenko

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Fustero, S., Simón-Fuentes, A., Delgado, O., Román, R. (2014). Fluorinated Pyrazoles and Indazoles. In: Nenajdenko, V. (eds) Fluorine in Heterocyclic Chemistry Volume 1. Springer, Cham. https://doi.org/10.1007/978-3-319-04346-3_7

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