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The Effects of Diet, Exercise, and Sleep on Brain Metabolism and Function

Abstract

Diet, exercise, and sleep have a major impact human health. Western diet, which is high in saturated fats refined carbohydrates, salt, and low in fiber is capable of producing a risk of promoting age-related chronic diseases such as cardiovascular disease, metabolic syndrome, arthritis, and neurotraumatic, neurodegenerative, and neuropsychiatric diseases. In contrast, Mediterranean diet with low saturated fats but rich in olive oil, omega 3 fatty acids, and garlic and fresh fruit and vegetable produces neuroprotective effects. Saturated fats and n-6 fatty acids promote inflammation and oxidative stress whereas fruits, vegetables, n-3 fatty acids, and olive oil retard inflammation and oxidative stress. Exercise produces beneficial effects by improving cardiovascular function, enhancing cognitive function, and maintaining normal cellular homeostasis. These processes retard mortality by decreasing coronary heart disease, and retarding neurological disorders. Exercise produces beneficial effects on neurotraumatic, neurodegenerative, and neuropsychiatric disorders. Age is a major non-modifiable risk factor risk factor for neurotraumatic, neurodegenerative, and neuropsychiatric diseases, but a positive family history, unhealthy lifestyle, and endogenous factors may also contribute to the pathogenesis of neurotraumatic, neurodegenerative, and neuropsychiatric diseases. An active lifestyle (healthy diet and exercise) and 6–7 h of sleep in middle age and late life can be two possible intervention strategies to retard and postpone the onset of neurotraumatic, neurodegenerative, and neuropsychiatric disorders.

Keywords

  • Lifestyle
  • Oxidative stress
  • Inflammation
  • n-3 fatty acids
  • n-6 Fatty acids
  • Neurological disorders
  • Neurotraumatic diseases
  • Neurodegenerative diseases
  • Reactive oxygen species (ROS)
  • Proinflammatory cytokines
  • Mitogen-activated protein kinase
  • Western diet
  • Ketogenic diet
  • Mediterranean diet
  • Caloric restriction
  • Vitagenes
  • Hormesis

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References

  • Abel T, Kandel E (1998) Positive and negative regulatory mechanisms that mediate long-term memory storage. Brain Res Brain Res Rev 26:360–378

    CAS  PubMed  Google Scholar 

  • Ahmed N (2005) Advanced glycation endproducts—role in pathology of diabetic complications. Diabetes Res Clin Pract 67:3–21

    CAS  PubMed  Google Scholar 

  • Ancoli-Israel S (2007) Sleep apnea in older adults—is it real and should age be the determining factor in the treatment decision matrix? Sleep Med Rev 11:83–85

    PubMed  PubMed Central  Google Scholar 

  • Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A (2008) SiRNA-mediated reduction of inhibitor of nuclear factor-κB kinase prevents tumor necrosis factor-α-induced insulin resistance in human skeletal muscle. Diabetes 57:2066–2073

    CAS  PubMed  Google Scholar 

  • Banks S, Dinges DF (2007) Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 3:519–528

    PubMed  Google Scholar 

  • Basheer R, Rainnie DG, Porkka Heiskanen T, Ramesh V, McCarley RW (2001) Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat. Neuroscience 104:731–739

    CAS  PubMed  Google Scholar 

  • Bayir H, Kagan VE (2008) Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis–there is nothing more practical than a good theory. Crit Care 12:206

    PubMed  Google Scholar 

  • Beebe DW, Groesz L, Wells C, Nichols A, McGee K (2003) The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data. Sleep 26:298–307

    PubMed  Google Scholar 

  • Bell EL, Guarente L (2011) The SirT3 divining rod points to oxidative stress. Mol Cell 42:561–568

    CAS  PubMed  PubMed Central  Google Scholar 

  • Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W (2004) Intranasal insulin improves memory in humans. Psychoneuroendocrinol 29:1326–1334

    CAS  Google Scholar 

  • Bengmark S (2013) Processed foods, dysbiosis, systemic inflammation, and poor health. Curr Nutri Food Sci 9:113–143

    CAS  Google Scholar 

  • Benington JH, Heller HC (1995) Restoration of brain energy metabolism as the function of sleep. Prog Neurobiol 14:347–360

    Google Scholar 

  • Benjamin N, O’Driscoll F, Dougall H, Duncan C, Smith L, Golden M, McKenzie H (1994) Stomach NO synthesis. Nature 368:502

    CAS  PubMed  Google Scholar 

  • Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME (2004) Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab 286:E852–E861

    Google Scholar 

  • Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME (2005) Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab 289:E429–E438

    Google Scholar 

  • Björne HH, Petersson J, Phillipson M, Weitzberg E, Holm L, Lundberg JO (2004) Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest 113:106–114

    PubMed Central  Google Scholar 

  • Bonda DJ, Lee HG, Camins A, Pallas M, Casadesus G, Smith MA, Zhu X (2011) The sirtuin pathway in aging and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol 10:275–279

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bori Z, Zhao Z, Koltai E, Fatouros IG, Jamurtas AZ, Douroudos II, Terzis G, Chatzinikolaou A, Sovatzidis A, Draganidis D, Boldogh I, Radak Z (2012) The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. Exp Gerontol 47:417–424

    CAS  PubMed  Google Scholar 

  • Bough KJ, Wetherington J, Hassel B, Rare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ (2006) Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol 60:223–235

    CAS  PubMed  Google Scholar 

  • Brandt JA, Churchill L, Rehman A, Ellis G, Memet S, Israel A, Krueger JM (2004) Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells. Brain Res 1004:91–97

    CAS  PubMed  Google Scholar 

  • Brownlee M (1995) Advanced glycosylation in diabetes and aging. Annu Rev Med 46:223–234

    CAS  PubMed  Google Scholar 

  • Bu Y, Rho S, Kim MY, Lee OH, Kim SY, Choi H, Kim H (2007) Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neurosci Lett 414:218–2121

    CAS  PubMed  Google Scholar 

  • Buxton OM, Marcelli E (2010) Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States. Social Sci Med 71:1027–1036

    Google Scholar 

  • Buxton OM, Ravlova M, Reid EW, Wang W, Simonson DC, Adler GK (2010a) Sleep restriction for one week reduces insulin sensitivity in healthy men. Diabetes 59:2126–2133

    CAS  Google Scholar 

  • Buxton OM, Cain SW, O’Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA (2012) Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 14:129ra43

    Google Scholar 

  • Cai DJ, Shuman T, Gorman MR, Sage JR, Anagnostaras SG (2009) Sleep selectively enhances hippocampus-dependent memory in mice. Behav Neurosci 123:713–719

    PubMed  Google Scholar 

  • Camargo LH, Alves FH, Biojones C, Correa FM, Resstel LB, Crestani CC (2013) Involvement of N-methyl-d-aspartate glutamate receptor and nitric oxide in cardiovascular responses to dynamic exercise in rats. Eur J Pharmacol 713:16–24

    CAS  PubMed  Google Scholar 

  • Carrier J, Monk TH, Buysse DJ, Kupfer D (1996) Amplitude reduction of the circadian temperature and sleep rhythms in the elderly. Chronobiol Int 13:373–386

    CAS  PubMed  Google Scholar 

  • Carskadon M, Dement WC (2005) Normal human sleep: an overview. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th ed. Elsevier Saunders, Philadelphia, pp 13–23

    Google Scholar 

  • Carter SL, Rennie CD, Hamilton SJ, Tarnopolsky MA (2001) Changes in skeletal muscle in males and females following endurance training. Can J Physiol Pharmacol 79:386–392

    CAS  PubMed  Google Scholar 

  • Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, Joseph JA (2004) Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 7:309–316

    CAS  PubMed  Google Scholar 

  • Chen H, Chan DC (2010) Physiological functions of mitochondrial fusion. Ann N Y Acad Sci 1201:21–25

    CAS  PubMed  Google Scholar 

  • Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, Xiong Y (2011) Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 12:534–541

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cirelli C, Gutierrez CM, Tononi G (2004) Extensive and divergent effects of sleep and wakefulness on brain gene expression. Neuron 14:35–43

    Google Scholar 

  • Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 4:e76

    PubMed  PubMed Central  Google Scholar 

  • Cizza G, Piaggi P, Lucassen EA, de Jonge L, Walter M, Mattingly MS, Kalish H, Csako G, Rother KI, Sleep Extension Study Group (2013) Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults. PLoS One 8:e65400

    CAS  PubMed  PubMed Central  Google Scholar 

  • Colcombe S, Kramer AF (2003) Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 14:125–130

    PubMed  Google Scholar 

  • Colcombe SJ, Erickson KI, Raz N, Webb AG, Cohen NJ, McAuley E, Kramer AF (2003) Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci 58:176–180

    PubMed  Google Scholar 

  • Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E, Cohen NJ, Webb A, Jerome GJ, Marquez DX, Elavsky S (2004) Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci USA 101:3316–3321

    CAS  PubMed  Google Scholar 

  • Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L, Kramer AF (2006) Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 61:1166–1170

    PubMed  Google Scholar 

  • Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325:201–204

    CAS  PubMed  PubMed Central  Google Scholar 

  • Combaret L, Dardevet D, Béchet D, Taillandier D, Mosoni L, Attaix D (2009) Skeletal muscle proteolysis in aging. Curr Opin Clin Nutr Metab Care 12:37–41

    PubMed  Google Scholar 

  • Conboy IM, Rando TA (2005) Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle 4:407–410

    CAS  PubMed  Google Scholar 

  • Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O’Keefe JH, Brand-Miller J (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81:341–354

    CAS  PubMed  Google Scholar 

  • Cornelius C, Perrotta R, Graziano A, Calabrese EJ, Calabrese V (2013) Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a “chi”. Immun Aging 10:15

    Google Scholar 

  • Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT (2003) Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9:1498–1505

    CAS  PubMed  Google Scholar 

  • Coyle CA, Jing E, Hosmer T, Powers JB, Wade G, Good DJ (2002) Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice. Physiol Behav 77:387–402

    CAS  PubMed  Google Scholar 

  • Da Silva AS, Pauli JR, Ropelle ER, Oliveira AG, Cintra DE, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ (2010) Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc 42:2180–2188

    CAS  PubMed  Google Scholar 

  • Daccache A, Lion C, Sibille N, Gerard M, Slomianny C, Lippens G, Cotelle P (2011) Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int 58:700–707

    CAS  PubMed  Google Scholar 

  • Dauncey MJ (2009) New insights into nutrition and cognitive neuroscience. Proc Nutr Soc 68:408–415

    CAS  PubMed  Google Scholar 

  • Dauncey MJ (2012) Recent advances in nutrition, genes and brain health. Proc Nutr Soc 71:581–591

    CAS  PubMed  Google Scholar 

  • de Alvaro C, Teruel T, Hernandez R, Lorenzo M (2004) Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279:17070–17078

    CAS  PubMed  Google Scholar 

  • Dejam A, Hunter CJ, Schechter AN, Gladwin M (2004) Emerging role of nitrite in human biology. Blood Cells Mol Dis 32:423–429

    CAS  PubMed  Google Scholar 

  • Dijk DJ, Duffy JF, Riel E, Shanahan TL, Czeisler CA (1999) Aging and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol 516:611–627

    CAS  PubMed  Google Scholar 

  • Ding YH, Ding Y, Li J, Bessert DA, Rafols JA (2006) Exercise pre-conditioning strengthens brain microvascular integrity in a rat stroke model. Neurol Res 28:184–189

    PubMed  Google Scholar 

  • Drake CL, Roehrs T, Roth T (2003) Insomnia causes, consequences, and therapeutics an overview. Depress Anxiety 184:163–176

    Google Scholar 

  • Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk DJ, Czeisler CA (2002) Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am J Physiol Endocrinol Metabo 282:E297–E303

    CAS  Google Scholar 

  • Duncan C, Dougall H, Johnston P, Green S, Brogan R, Leifert C, Smith L, Golden M, Benjamin N (1995) Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrite. Nat Med 1:546–551

    CAS  PubMed  Google Scholar 

  • Durmer JS, Dinges DF (2005) Neurocognitive consequences of sleep deprivation. Semin Neurol 25:117–129

    PubMed  Google Scholar 

  • Erickson KI, Kramer AF (2009) Aerobic exercise effects on cognitive and neural plasticity in older adults. Br J Sports Med 43:22–24

    CAS  PubMed  PubMed Central  Google Scholar 

  • Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L, Morris KS, White SM, Wojcicki TR, McAuley E, Kramer AF (2009) Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19:1030–1039

    PubMed  PubMed Central  Google Scholar 

  • Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult human hippocampus. Nat Med 4:1313–1317

    CAS  PubMed  Google Scholar 

  • Faraut B, Boudjeltia KZ, Vanhamme L, Kerkhofs M (2012) Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery. Sleep Med Rev 14:137–149

    Google Scholar 

  • Farooqui AA (2009) Beneficial effects of fish oil on human brain. Springer, New York

    Google Scholar 

  • Farooqui AA (2010) Neurochemical aspects of neurodegenerative and neurotraumatic diseases. Springer, New York

    Google Scholar 

  • Farooqui AA (2011) Lipid mediators and their metabolism in the brain. Springer, New York

    Google Scholar 

  • Farooqui AA (2012) Phytochemicals, signal transduction, and neurological disorders. Springer, New York

    Google Scholar 

  • Farooqui AA, Farooqui T, Panza F, Frisardi V (2012) Metabolic syndrome as a risk factor for neurological disorders. Cell Mol Life Sci 69:741–762

    CAS  PubMed  Google Scholar 

  • Farooqui AA (2013a) Metabolic syndrome an important risk factor for stroke, alzheimer disease and depression. Springer, New York

    Google Scholar 

  • Farooqui AA (2013b) n-3 fatty acid-derived lipid mediators against neurological oxidative stress and neuroinflammation in Omega-3 fatty acids in Brain and Neurological Health. In: Watson RR, De Meester F (eds). Elsvier, PA

    Google Scholar 

  • Farr SA, Price TO, Dominguez LJ, Motisi A, Saiano F, Niehoff ML, Morley JE, Banks WA, Ercal N, Barbagallo M (2012) Extra virgin olive oil improves learning and memory in SAMP8 mice. J Alzheimers Dis 28:81–92

    CAS  PubMed  Google Scholar 

  • Febbraio MA (2007) Exercise and inflammation. J Appl Physiol 103:376–377

    CAS  PubMed  Google Scholar 

  • Fernström M, Tonkonogi M, Sahlin K (2004) Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J Physiol 554:755–763

    PubMed  Google Scholar 

  • Fessler MB, Rudel LL, Brown JM (2009) Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol 20:379–385

    CAS  PubMed  PubMed Central  Google Scholar 

  • Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, Ruzickova J, Sponarova J, Drahota Z, Vlcek C, Keijer J, Houstek J, Kopecky J (2005) Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 48:2365–2375

    CAS  PubMed  Google Scholar 

  • Fontan-Lozano A, Lopez-lluch G, Delgado-Garcia JM, Navas P, Carrion AM (2008) Molecular bases of caloric restriction regulation of neuronal synaptic plasticity. Mol Neurobiol 38:167–177

    CAS  PubMed  Google Scholar 

  • Fox DL, Vella KR, Good DJ (2007) Energy balance pathways converging on the Nhlh2 transcription factor. Front Biosci 12:3983–3993

    CAS  PubMed  Google Scholar 

  • Freeman J, Veggiotti P, Lanzi G, Tagliabue A, Perucca E (2006) The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Res 68:145–180

    CAS  PubMed  Google Scholar 

  • Furuya TK, da Silva PN, Payao SL, Rasmussen LT, de Labio RW, Bertolucci PH, Braga IL, Chen ES, Turecki G, Mechawar N, Mill J, de Arruda Cardoso Smith M (2012) SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s disease. Neurochem Int 61:973–975

    CAS  PubMed  Google Scholar 

  • Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender RM, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A (2006) 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci 9:1382–1387

    CAS  PubMed  Google Scholar 

  • Gasior M, Rogawski MA, Hartman AL (2006) Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol 17:431–439

    CAS  PubMed  PubMed Central  Google Scholar 

  • Giralt A, Villarroya F (2012) SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. Biochem J 444:1–10

    CAS  PubMed  Google Scholar 

  • Gleeson M (2007) Immune function in sport and exercise. J Appl Physiol 103:693–699

    CAS  PubMed  Google Scholar 

  • Gleeson M, McFarlin B, Flynn M (2006) Exercise and Toll-like receptors. Exerc Immunol Rev 12:34–53

    PubMed  Google Scholar 

  • Gleeson M, Nieman DC, Pedersen BK (2004) Exercise, nutrition and immune function. J Sports Sci 22:115–125

    PubMed  Google Scholar 

  • Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11:607–615

    CAS  PubMed  Google Scholar 

  • Goh KC, Lim YP, Ong SH, Siak CB, Cao X, Tan YH, Guy GR (1996) Identification of p90, a prominent tyrosine-phosphorylated protein in fibroblast growth factor-stimulated cells, as 80K-H. J Biol Chem 271:5832–5838

    CAS  PubMed  Google Scholar 

  • Good DJ, Porter FD, Mahon KA, Parlow AF, Westphal H, Kirsch IR (1997) Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet 15:397–401

    CAS  PubMed  Google Scholar 

  • Good DJ, Coyle CA, Fox DL (2008) Nhlh2: A Basic Helix-Loop-Helix Transcription Factor Controlling Physical Activity. Exerc Sport Sci Rev 36:187–192

    PubMed  PubMed Central  Google Scholar 

  • Gottlieb RA, Carreira RS (2010) Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol 299:C203–C210

    Google Scholar 

  • Gozal D, Daniel JM, Dohanich GP (2001) Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurosci 21:2442–2450

    CAS  PubMed  Google Scholar 

  • Granda B, Tabernero A, Tello V, Medina JM (2000) Oleic acid induces GAP-43 expression through a protein kinase C-mediated mechanism that is independent of NGF but synergistic with NT-3 and NT-4/5. Brain Res 988:1–8

    Google Scholar 

  • Grandner MA, Hale L, Moore M, Patel NP (2010) Mortality associated with short sleep duration: the evidence, the possible mechanisms, and the future. Sleep Med Rev 14:191–203

    PubMed  PubMed Central  Google Scholar 

  • Granholm AC, Bimonte-Nelson HA, Moore AB, Nelson ME, Freeman LR, Sambamurti K (2008) Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis 14:133–145

    CAS  PubMed  PubMed Central  Google Scholar 

  • Green DJ, Spence A, Halliwill JR, Cable NT, Thijssen DH (2011) Exercise and vascular adaptation in asymptomatic humans. Exp Physiol 96:57–70

    PubMed  Google Scholar 

  • Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S (2012) Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One 7:e51180

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ (2005) Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. Am J Physiol Endocrinol Metab 288:E674–E684

    CAS  PubMed  Google Scholar 

  • Halagappa VK, Guo Z, Pearson M (2007) Intermittent fasting and caloric restriction ameliorate age-related behavioural deficits in the triple-transgenic mouse model of Alzheimer’s disease. Neurobiol Dis 26:212–220

    CAS  PubMed  Google Scholar 

  • Hall MH, Matthews KA, Kravitz HM, Gold EB, Buysse DJ, Bromberger JT, Owens JF, Sowers M (2009) Race and financial strain are independent correlates of sleep in midlife women: the SWAN sleep study. Sleep 32:73–82

    PubMed  Google Scholar 

  • Handschin C, Spiegelman BM (2008) The role of exercise and PGC1α in inflammation and chronic disease. Nature 454:463–469

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hanlon EC, Van Cauter E (2011) Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism. Proc Natl Acad Sci USA 14:15609–15616

    Google Scholar 

  • Havekes R, Vecsey CG, Abel T (2012) The impact of sleep deprivation on neuronal and glial signalling pathways important for memory and synaptic plasticity. Cell Signal 24:1251–1260

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hawley JA, Lessard SJ (2008) Exercise training-induced improvements in insulin action. Acta Physiol 192:127–135

    CAS  Google Scholar 

  • Heine VM, Maslam S, Joels M, Lucassen PJ (2004) Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation. Neurobiol Aging 25:361–375

    CAS  PubMed  Google Scholar 

  • Hillman CH, Erickson KI, Kramer AF (2008) Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 9:58–65

    CAS  PubMed  Google Scholar 

  • Hipkiss AR (2008) Energy metabolism, altered proteins, sirtuins and aging: converging mechanisms? Biogerontology 9:49–55

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C (2008) Long-term effects of caloric restriction or exercise on Dna and Rna oxidation levels in white blood cells and urine in humans. Rejuvenation Res 11:793–799

    CAS  PubMed  Google Scholar 

  • Horch HW (2004) Local effects of BDNF on dendritic growth. Rev Neurosci 15:117–129

    CAS  PubMed  Google Scholar 

  • Houmard JA, Shinebarger MH, Dolan PL, Leggettfrazier N, Bruner RK, Mccammon MR, Israel RG, Dohm GL (1993) Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men. Am J Physiol 264:E896–E901

    CAS  PubMed  Google Scholar 

  • Hu K, Van Someren EJ, Shea SA, Scheer FA (2009) Reduction of scale invariance of activity fluctuations with aging and Alzheimer’s disease: involvement of the circadian pacemaker. Proc Natl Acad Sci USA 106:2490–2494

    CAS  PubMed  Google Scholar 

  • Huang YL, Liu RY, Wang QS, Van Someren EJ, Xu H, Zhou JN (2002) Age-associated difference in circadian sleep-wake and rest-activity rhythms. Physiol Behav 76:597–603

    CAS  PubMed  Google Scholar 

  • Impey S, Obrietan K, Storm DR (1999) Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 23:11–14

    CAS  PubMed  Google Scholar 

  • Ip EY, Zanier ER, Moore AH, Lee SM, Hovda DA (2003) Metabolic, neurochemical, and histologic responses to vibrissa motor cortex stimulation after traumatic brain injury. J Cereb Blood Flow Metab 23:900–910

    PubMed  Google Scholar 

  • Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC, Martinez Maza O, Cole S (2008) Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 64:538–540

    CAS  PubMed  PubMed Central  Google Scholar 

  • Izadpanah A, Barnard RJ, Almeda AJ, Baldwin GC, Bridges SA, Shellman ER, Burant CF, Roberts CK (2012) A short-term diet and exercise intervention ameliorates inflammation and markers of metabolic health in overweight/obese children. Am J Physiol Endocrinol Metab 303:E542–E550

    Google Scholar 

  • Jeong EA, Jeon BT, Shin HJ, Kim N, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS (2011) Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. Exp Neurol 232:195–202

    CAS  PubMed  Google Scholar 

  • Jew S, AbuMweis SS, Jones PJ (2009) Evolution of the human diet: linking our ancestral diet to modern functional foods as a means of chronic disease prevention. J Med Food 12:925–934

    CAS  PubMed  Google Scholar 

  • Kanoski SE, Meisel RL, Mullins AJ, Davidson TL (2007) The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behav Brain Res 182:57–66

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kato M, Phillips BG, Sigurdsson G, Narkiewicz K, Pesek CA, Somers VK (2000) Effects of sleep deprivation on neural circulatory control. Hypertension 35:1173–1175

    CAS  PubMed  Google Scholar 

  • Khan WA, Blobe GC, Hunnun YA (1992) Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. J Biol Chem 267:3605–3612

    CAS  PubMed  Google Scholar 

  • Kim doY, Hao J, Liu R, Turner G, Shi FD, Rho M (2012) Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLos One 7:e35476

    CAS  PubMed Central  Google Scholar 

  • Kim do Y, Rho JM (2008) The ketogenic diet and epilepsy. Curr Opin Clin Nutr Metab Care 11:113–120

    CAS  Google Scholar 

  • Kim JH, Jung KJ, Seo AY, Choi JS, Yu BP, Chung HY (2002) Calorie restriction modulates redox-sensitive AP-1 during the aging process. J Am Aging Assoc 25:123–130

    CAS  Google Scholar 

  • Kim J, Hakim F, Kheirandish-Gozal L, Gozal D (2011) Inflammatory pathways in children with insufficient or disordered sleep. Respir Physiol Neurobiol 178:465–474

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kottai E, Hart N, Taylor AW, Goto S, Ngo JK, Davies KJ, Radak Z (2012) Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiology Regul Integr Comp Physiol 303:R127–R134

    Google Scholar 

  • Lakka TA, Laaksonen DE (2007) Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab 32:76–88

    PubMed  Google Scholar 

  • LaManna JC, Salem N, Puchowicz M, Erokwu B, Koppaka S, Flask C, Lee Z (2009) Ketones suppress brain glucose consumption. Adv Exp Med Biol 645:301–306

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lambert AJ, Wang B, Yardley J, Edwards J, Merry BJ (2004) The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp Gerontol 39:289–295

    CAS  PubMed  Google Scholar 

  • Lange T, Dimitrov S, Born J (2010) Effects of sleep and circadian rhythm on the human immune system. Ann N Y Acad Sci 14:48–59

    Google Scholar 

  • Lanza IR, Sreekumaran Nair K (2010) Regulation of skeletal muscle mitochondrial function: genes to proteins. Acta Physiol (Oxf) 199:529–547

    CAS  Google Scholar 

  • Larsen FJ, Ekblom B, Sahlin K, Lundberg JO, Weitzberg E (2006) Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med 355:2792–2793

    CAS  PubMed  Google Scholar 

  • Larsson L, Ansved T (1995) Effects of aging on the motor unit. Prog Neurobiol 45:397–458

    CAS  PubMed  Google Scholar 

  • Lavado E, Sanchez-Abarca LI, Tabernero A, Bolanos JP, Medina JM (1997) Oleic acid inhibits gap junction permeability and increases glucose uptake in cultured rat astrocytes. J Neurochem 69:721–728

    CAS  PubMed  Google Scholar 

  • Lee J, Duan W, Long JM, Ingram DK, Mattson MP (2000) Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J Mol Neurosci 15:99–108

    CAS  PubMed  Google Scholar 

  • Leckie RL, Weinstein AM, Hodzic JC, Erickson KI (2012) Potential moderators of physical activity on brain health. J Aging Res. 2012:948981.

    Google Scholar 

  • Lee J, Duan W, Mattson MP (2002) Evidence that brain derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367–1375

    CAS  PubMed  Google Scholar 

  • Leitzmann MF, Park Y, Blair A, Ballard-Barbash R, Mouw T, Hollenbeck AR, Schatzkin A (2007) Physical activity recommendations and decreased risk of mortality. Arch Intern Med 167:2453–2460

    PubMed  Google Scholar 

  • Lévy P, Pépin JL, Arnaud C, Tamisier R, Borel JC, Dematteis M, Godin-Ribuot D, Ribuot C (2008) Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Resp J 32:1082–1095

    Google Scholar 

  • Li YM, Mitsuhashi T, Wojciechowicz D, Shimizu N, Li J, Stitt A, He C, Banerjee D, Vlassara H (1996) Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins. Proc Natl Acad Sci U S A 93:11047–11052

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li ZG, Zhang W, Sima AA (2007) Alzheimer-like changes in rat models of spontaneous diabetes. Diabetes 56:1817–1824

    CAS  PubMed  Google Scholar 

  • Liao F, Andalibi A, Debeer FC, Fogelman AM, Lusis AJ (1993) Genetic control of inflammatory gene induction and Nf-kappa B-like transcription factor activation in response to an atherogenic diet in mice. J Clin Invest 91:2572–2579

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lin J, Handschin C, Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361–370

    PubMed  Google Scholar 

  • Liu D, Chan SL, De Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, De Cabo R, Mattson MP (2006) Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 8:389–414

    CAS  PubMed  Google Scholar 

  • Lopez-Miranda J, Delgado-Lista J, Perez-Martinez P, Jimenez-Gomez Y, Fuentes F, Ruano J, Marin C (2007) Olive oil and the haemostatic system. Mol Nut Food Res 51:1249–1259

    CAS  Google Scholar 

  • Louissaint A Jr, Rao S, Leventhal C, Goldman SA (2002) Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34:945–960

    CAS  PubMed  Google Scholar 

  • Love R (2005) Calorie restriction may be neuroprotective in AD and PD. Lancet Neurol 4:84

    PubMed  Google Scholar 

  • Lundberg JO, Feelisch M, Björne H, Jansson EA, Weitzberg E (2006) Cardioprotective effects of vegetables: is nitrite the answer? Nitric Oxide 15:359–362

    CAS  PubMed  Google Scholar 

  • Maafouf MA, Rho JM, Mattson MP (2009) The neuroprotective properties of calories restriction, the ketogenic diet, and ketone bodies. Brain Res Rev 59:293–315

    Google Scholar 

  • Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, Naidoo N, Baldwin DA, Jensen ST, Churchill GA, Pack AI (2007) Macromolecule biosynthesis: a key function of sleep. Physiol Genomics 14:441–457

    Google Scholar 

  • Madigan M, Zuckerbraun B (2013) Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol 4:174

    PubMed  PubMed Central  Google Scholar 

  • Maret S, Dorsaz S, Gurcel L, Pradervand S, Petit B, Pfister C, Hagenbuchle O, O’Hara BF, Franken P, Tafti M (2007) Homer1a is a core brain molecular correlate of sleep loss. Proc Natl Acad Sci USA 14:20090–20095

    Google Scholar 

  • Martin B, Mattson MP, Maudsley S (2006) Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Aging Res Rev 5:332–353

    CAS  Google Scholar 

  • Masswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK (2004) Caloric resdtriction increases neurotrophic factor levels and attenuates neurochemical and behavioural deficits in a primate model of Parkinson’s disease. Proc Natl Acad Sci USA 101:18171–18176

    Google Scholar 

  • Mattson MP (2008a) Hormesis defined. Aging Res Rev 7:1–7

    CAS  Google Scholar 

  • Mattson MP (2008b) Dietary factors, hormesis and health. Aging Res Rev 7:43–48

    Google Scholar 

  • Mattson MP, Cheng A (2006) Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci 29:632–639

    CAS  PubMed  Google Scholar 

  • Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges NJ, Dinges DF, Mullington JM (2004) Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43:678–683

    CAS  PubMed  Google Scholar 

  • Mendham AE, Donges CE, Liberts EA, Duffield R (2011) Effects of mode and intensity on the acute exerciseinduced IL-6 and CRP responses in a sedentary, overweight population. Eur J Applied Physiol 111:1035–1045

    CAS  Google Scholar 

  • Milder JB, Liang LP, Patel M (2010) Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet. Neurobiol Dis 40:238–244

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miyoshi M, Kasahara E, Park AM, Hiramoto K, Minamiyama Y, Takemura S, Sato EF, Inoue M (2003) Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat. Free Radic Res 37:85–90

    CAS  PubMed  Google Scholar 

  • Mladenovic Djordjevic A, Perovic M, Tesic V, Tanic N, Rakic L, Ruzdijic S, Kanazir S (2010) Long-term dietary restriction modulates the level of presynaptic proteins in the cortex and hippocampus of the aging rat. Neurochem Int 56:250–255

    PubMed  Google Scholar 

  • Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ (2013) Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci USA 110:E1132–E1141

    Google Scholar 

  • Mora F, Segovia G, del Arco A (2007) Aging, plasticity and envrionmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 55:78–88

    CAS  PubMed  Google Scholar 

  • Morris GO, Williams HL, Lubin A (1960) Misperception and disorientation during sleep deprivation. Arch Gen Psychiatry 2:247–254

    Google Scholar 

  • Morton JP, Kayani AC, McArdle A, Drust B (2009) The exercise-induced stress response of skeletal muscle, with specific emphasis on humans. Sports Med 39:643–662

    PubMed  Google Scholar 

  • Musa-Veloso K, Likhodii SS, Cunnane SC (2002) Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. Am J Clin Nutr 76:65–70

    CAS  PubMed  Google Scholar 

  • Naidoo N (2009) Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev 14:195–204

    Google Scholar 

  • Naidoo N, Giang W, Galante RJ, Pack AI (2005) Sleep deprivation induces the unfolded protein response in mouse cerebral cortex. J Neurochem 14:1150–1157

    Google Scholar 

  • Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell 134:405–415

    CAS  PubMed  PubMed Central  Google Scholar 

  • Neeper SA, Gomez-Pinilla F, Choi J, Cotman CW (1996) Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 726:49–56

    CAS  PubMed  Google Scholar 

  • New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71:142–151

    CAS  PubMed  Google Scholar 

  • Nieman DC (2003) Current perspective on exercise immunology. Curr Sports Med Rep 2:239–242

    PubMed  Google Scholar 

  • Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314–317

    CAS  PubMed  Google Scholar 

  • Nisoli E, Clementi E, Carruba MO, Moncada S (2007) Defetive mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 100:795–806

    CAS  PubMed  Google Scholar 

  • Nunn AV, Guy GW, Brodie JS, Bell JD (2010) Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle. Nutr Metab (Lond) 9(7):87

    Google Scholar 

  • Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273

    PubMed  Google Scholar 

  • Oliveira AG, Carvalho BM, Tobar N, Ropelle ER, Pauli JR, Bagarolli RA, Guadagnini D, Carvalheira JB, Saad MJ (2011) Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats. Diabetes 60:784–796

    CAS  PubMed  Google Scholar 

  • Pahkala K, Heinonen OJ, Simell O, Viikari JS, Rönnemaa T, Niinikoski H, Raitakari OT (2011) Association of physical activity with vascular endothelial function and intima-media thickness. Circulation 124:1956–1963

    PubMed  Google Scholar 

  • Palmer TD, Willhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425:479–944

    CAS  PubMed  Google Scholar 

  • Parish JM, Somers VK (2004) Obstructive sleep apnea and cardiovascular disease. Mayo Clinic Proceedings 79:1036–1046

    PubMed  Google Scholar 

  • Pasinetti GM, Eberstein JA (2008) Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease. J Neurochem 106:1503–1514

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA (2007) An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA 104:5638–5643

    CAS  PubMed  Google Scholar 

  • Perez-Jemenez F, Lista JD, Perez-Martinez P, Lopez-Segura F, Fuentes F, Cortes B, Lazano A, Lopez-Miranda J (2006) Olive oil and haemostasis: a review on its healthy effects. Public Health Nutr 9:1083–1088

    Google Scholar 

  • Perez-Jimenez F, Ruano J, Perez-Martinez P, Lopez-Segura F, Lopez-Miranda J (2007) The influence of olive oil on human health: not a question of fat alone. Mol Nutr Food Res 51:1199–1208

    CAS  PubMed  Google Scholar 

  • Petersen AM, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98:1154–1162

    CAS  PubMed  Google Scholar 

  • Peters A, Langemann D (2009) Build-ups in the supply chain of the brain: on the neuroenergetic cause of obesity and type 2 diabetes mellitus. Front Neuroenergetics 1:2

    PubMed  PubMed Central  Google Scholar 

  • Peters A, Kubera B, Hubold C, Langemann D (2011) The selfish brain: stress and eating behavior. Front Neurosci 5:74

    PubMed  PubMed Central  Google Scholar 

  • Phillip P, Akerstedt T (2006) Transport and industrial safety: how are they affected by sleepiness and sleep restriction? Sleep Med Rev 10:347–356

    Google Scholar 

  • Pifferi F, Roux F, Langelier B, Alessandri JM, Vancassel S, Jouin M, Lavialle M, Guesnet P (2005) (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J Nutr 135:2241–2246

    CAS  PubMed  Google Scholar 

  • Poe GR, Walsh CM, Bjorness TE (2010) Cognitive neuroscience of sleep. Prog Brain Res 185:1–19

    PubMed  Google Scholar 

  • Politi K, Shemer-Meiri L, Shuper A, Aharoni S (2011) The ketogenic diet 2011: how it works. Epilepsy Res Treat 2011:963637

    PubMed  PubMed Central  Google Scholar 

  • Qiu X, Brown K, Hirschey MD, Verdin E, Chen D (2010) Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12:662–667

    CAS  PubMed  Google Scholar 

  • Rahman A, Akterin S, Flores-Morales A, Crisby M, Kivipelto M, Schultzberg M, Cedazo-Mínguez A (2005) High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice. FEBS Lett 579:6411–6416

    CAS  PubMed  Google Scholar 

  • Ramesh V, Thatte HS, McCarley RW, Basheer R (2007) Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain. J Neurochem 100:1351–1363

    CAS  PubMed  Google Scholar 

  • Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Pérusse L, Bouchard C (2006) The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14:529–644

    Google Scholar 

  • Ravassard P, Pachoud B, Comte JC, Mejia-Perez C, Scote-Blachon C, Gay N, Claustrat B, Touret M, Luppi PH, Salin PA (2009) Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus. Sleep 32:227–240

    PubMed  Google Scholar 

  • Reagan LP (2007) Insulin signaling effects on memory and mood. Curr Opin Pharmacol 7:633–637

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rechtschaffen A, Siegel J (2000) Sleep and dreaming. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neural science, 4th ed. McGraw-Hill, New York, pp 936–947

    Google Scholar 

  • Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361:1545–1564

    CAS  PubMed  Google Scholar 

  • Rigacci S, Guidotti V, Bucciantini M, Parri M, Nediani C, Cerbai E, Stefani M, Berti A (2010) Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin. J Nutr Biochem 21:726–735

    CAS  PubMed  Google Scholar 

  • Rigacci S, Guidotti V, Bucciantini M, Nichino D, Relini A, Berti A, Stefani M (2011) Abeta(1–42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res 8:841–852

    CAS  PubMed  Google Scholar 

  • Rodríguez-Rodríguez RA, Tabernero A, Velasco A, Lavado EM, Medina JM (2004) The neurotrophic effect of oleic acid includes dendritic differentiation and the expression of the neuronal basic helix-loop-helix transcription factor NeuroD2. J Neurochem 88:1041–1051

    PubMed  Google Scholar 

  • Romcy-Pereira R, Pavlides C (2004) Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP. Eur J Neurosci 20:3453–3462

    PubMed  Google Scholar 

  • Roth TL, Sweatt JD (2008) Rhythms of memory. Nat Neurosci 11:993–994

    CAS  PubMed  Google Scholar 

  • Saetre T, Enoksen E, Lyberg T, Stranden E, Jørgensen JJ, Sundhagen JO, Hisdal J (2011) Supervised exercise training reduces plasma levels of the endothelial inflammatory markers E-selectin and ICAM-1 in patients with peripheral arterial disease. Angiol 62:301–305

    CAS  Google Scholar 

  • Sakuma K, Yamaguchi A (2012) Sarcopenia and age-related endocrine function. Int J Endocrinol 2012:127362

    PubMed  PubMed Central  Google Scholar 

  • Satlin A, Teicher MH, Lieberman HR, Baldessarini RJ, Volicer L, Rheaume Y (1991) Circadian locomotor activity rhythms in Alzheimer’s disease. Neuropsychopharmacol 5:115–126

    CAS  Google Scholar 

  • Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol 59:912–921

    PubMed  PubMed Central  Google Scholar 

  • Scarpulla RC (2008) Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann NY Acad Sci 1147:321–334

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schafer A, Reichert AS (2009) Emerging roles of mitochondrial membrane dynamics in health and disease. Biol Chem 390:707–715

    PubMed  Google Scholar 

  • Scharf MT, Naidoo N, Zimmerman JE, Pack AI (2008) The energy hypothesis of sleep revisited. Prog Neurobiol 14:264–280

    Google Scholar 

  • Schuit AJ, Feskens EJM, Launer LJ, Kromhout D (2001) Physical activity and cognitive decline, the role of the apolipoprotein e4 allele. Med Sci Sports Exer 33:772–777

    CAS  Google Scholar 

  • Scott JPR, Sale C, Greeves JP, Casey A, Dutton J, Fraser WD (2011) Effect of exercise intensity in the cytokine response to an acute bout of running. Med Sci Sports Exerc 43:2297–2306

    CAS  PubMed  Google Scholar 

  • Seneff S, Wainwright G, Mascitelli L (2011) Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet. Eur J Intern Med 22:134–140

    CAS  PubMed  Google Scholar 

  • Short KR (2009) Introduction to symposium proceedings: the emerging interplay among muscle mitochondrial function, nutrition and disease. Am J Clin Nutr 89:453S–454S

    Google Scholar 

  • Simopoulos AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 233:674–688

    CAS  Google Scholar 

  • Simopoulos AP (2009) Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. World Rev Nutr Diet 100:1–21

    CAS  PubMed  Google Scholar 

  • Sindreu CB, Scheiner ZS, Storm DR (2007) Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron 53:79–89

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sirota A, Csicsvari J, Buhl D, Buzsaki G (2003) Communication between neo-cortex and hippocampus during sleep in rodents. Proc Natl Acad Sci U S A 100:2065–2069

    CAS  PubMed  PubMed Central  Google Scholar 

  • Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokera M, Denu JM, Prolla TA (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143:802–812

    CAS  PubMed  PubMed Central  Google Scholar 

  • Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 354:1435–1439

    CAS  PubMed  Google Scholar 

  • Spiegel K, Leproult R, L’Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E (2004) Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 89:5762–5771

    CAS  PubMed  Google Scholar 

  • Stickgold R (2005) Sleep-dependent memory consolidation. Nature 437:1272–1278

    CAS  PubMed  Google Scholar 

  • Stranahan AM, Mattson MP (2012) Recruiting adaptive cellular stress responses for successful brain aging. Nat Rev Neurosci 13:209–216

    CAS  PubMed  Google Scholar 

  • Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP (2008) Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 18:1085–1088

    PubMed  PubMed Central  Google Scholar 

  • Stranahan AM, Zhou Y, Martin B, Maudsley S (2009) Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem 16:4668–4678

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stranahan AM, Lee K, Becker KG, Zhang Y, Maudeley S, Marlin B, Cutler RG, Mattson MP (2010) Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging 31:1937–1949

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stroth S, Reinhardt RK, Thöne J, Hille K, Schneider M, Härtel S, Weidemann W, Bös K, Spitzer M (2010) Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults. Neurobiol Learn Mem 94:364–372

    CAS  PubMed  Google Scholar 

  • Sullivan PG, Rippy NA, Dorenbos K, Concepcion RC, Agarwal AK, Rho JM (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann Neurol 55:576–580

    CAS  PubMed  Google Scholar 

  • Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, Konda S, Engberg K, Lauterbur PC, Greenough WT (2003) Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 117:1037–1046

    CAS  PubMed  Google Scholar 

  • Sweatt JD (2004) Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol 14:311–317

    CAS  PubMed  Google Scholar 

  • Tabernero A, Lavado EM, Granda B, Velasco A, Medina JM (2001) Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes. J Neurochem 79:606–616

    CAS  PubMed  Google Scholar 

  • Tabernero A, Velasco A, Granda B, Lavado EM, Medina JM (2002) Transcytosis of albumin in astrocytes activates the sterol regulatory element-binding protein-1, which promotes the synthesis of the neurotrophic factor oleic acid. J Biol Chem 277:4240–4246

    CAS  PubMed  Google Scholar 

  • Thaler JP, Schwartz MW (2010) Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 151:4109–4115

    CAS  PubMed  Google Scholar 

  • Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153–162

    CAS  PubMed  PubMed Central  Google Scholar 

  • Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR (2008) High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem 106:475–485

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tochikubo O, Ikeda A, Miyajima E, Ishii M (1996) Effects of insufficient sleep on blood pressure monitored by a new multibiomedical recorder. Hypertension 27:1318–1324

    CAS  PubMed  Google Scholar 

  • Tononi G, Cirelli C (2003) Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull 14:143–150

    Google Scholar 

  • Tylavsky FA, Spence LA, Harkness L (2008) The importance of calcium, potassium, and acid-base homeostasis in bone health and osteoporosis prevention. J Nutr 138:164S–165S

    CAS  PubMed  Google Scholar 

  • Uo T, Dworzak J, Kinoshita C, Inman DM, Kinoshita Y et al (2009) Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. Exp Neurol 218:274–285

    CAS  PubMed  PubMed Central  Google Scholar 

  • Van Bruggen MD, Hackney AC, McMurray RG, Ondrak KS (2011) The relationship between serum and salivary cortisol levels in response to different intensities of exercise. Int J Sports Physiol Perform 6:396–407

    Google Scholar 

  • Van Cauter E, Spiegel K, Tasali E, Leproult R (2008) Metabolic consequences of sleep and sleep loss. Sleep Med 14(Suppl 1):S23–S28

    Google Scholar 

  • Van der Auwera I, Wera S, Van Leuven F, Henderson ST (2005) A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease. Nutr Metab (Lond) 2:28

    Google Scholar 

  • van Praag H, Kempermann G, Gage FH (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266–270

    CAS  PubMed  Google Scholar 

  • van Praag H, Shubert T, Zhao C, Gage FH (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680–8685

    CAS  PubMed  Google Scholar 

  • Vaynman S, Ying Z, Gomez-Pinilla F (2004) Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20:2580–2590

    PubMed  Google Scholar 

  • Vaynman S, Ying Z, Wu A, Gomez-Pinilla F (2006) Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. Neuroscience 139:1221–1234

    CAS  PubMed  Google Scholar 

  • Vecsey CG, Baillie GS, Jaganath D, Havekes R, Daniels A, Wimmer M, Huang T, Brown KM, Li XY, Descalzi G, Kim SS, Chen T, Shang YZ, Zhuo M, Houslay MD, Abel T (2009) Sleep deprivation impairs cAMP signalling in the hippocampus. Nature 461:1122–1125

    CAS  PubMed  PubMed Central  Google Scholar 

  • Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr (2001) Ketone bodies, potential therapeutic uses. IUBMB Life 51:241–247

    CAS  PubMed  Google Scholar 

  • Vlassara H, Li YM, Imani F, Wojciechowicz D, Yang Z, Liu FT, Cerami A (1995) Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Mol Med 1:634–646

    CAS  PubMed  PubMed Central  Google Scholar 

  • Vormann J, Remer T (2008) Dietary, metabolic, physiologic, and disease-related aspects of acid-base balance: foreword to the contributions of the second International Acid-Base Symposium. J Nutr 138:413S–414S

    CAS  PubMed  Google Scholar 

  • Voskuyl RA, Vreugdenhil M (2001). Effects of essential fatty acids on voltage-regulated ionic channels and seizure thresholds in animals. In: Mostofsky D, Yehuda S, Salem N Jr (eds) Fatty acids: physiological and behavioral functions. Humana Press, Totowa, pp 63–78

    Google Scholar 

  • Voss MW, Erickson KI, Prakash RS, Chaddock L, Malkowski E, Alves H, Kim JS, Morris KS, White SM, Wójcicki TR, Hu L, Szabo A, Klamm E, McAuley E, Kramer AF (2010) Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition? Neuropsychologia 48:1394–1406

    PubMed  PubMed Central  Google Scholar 

  • Walker MP, Stickgold R (2006) Sleep, memory, and plasticity. Annu Rev Psychol 14:139–166

    Google Scholar 

  • Walsh NP, Gleeson M, Pyne DB et al. (2011) Position statement. Part two: maintaining immune health. Exercise Immunol Rev 17:6–63

    Google Scholar 

  • Wang XL, Alex Fu, Raghavakaimal S, Lee HC (2007) Proteomic analysis of vascular endothelial cells in response to laminar shear stress. Proteomics 7:588–596

    CAS  PubMed  Google Scholar 

  • Wang H, Liu Y, Briesemann M, Yan J (2010b) Computational analysis of gene regulation in animal sleep deprivation. Physiol Genomics 14:427–436

    Google Scholar 

  • Wang J, Fivecoat H, Ho L, Pan Y, Ling E (2010a) The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology. Biochim Biophys Acta 1804:1690–1694

    CAS  Google Scholar 

  • Warburton DER, Nicol CW, Bredin SSD (2006) Health benefits of physical activity: the evidence. Can Med Asso J 174:801–809

    Google Scholar 

  • Weber TA, Reichert AS (2010) Impaired quality control of mitochondria: aging from a new perspective. Exp Gerontol 45:503–511

    CAS  PubMed  Google Scholar 

  • Wilder RM (1921) The effects of ketonemia on the course of epilepsy. Mayo Clin Bull 2:307–308

    Google Scholar 

  • Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61(suppl 6):S1402–S1406

    Google Scholar 

  • Witte AV, Fobker M, Gellner R, Knecht S, Floel A (2009) Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci USA 106:1255–1260

    CAS  PubMed  Google Scholar 

  • Xie H, Yung WH (2012) Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor. Acta Pharmacol Sinica 33:5–10

    CAS  Google Scholar 

  • Yoo SS, Hu PT, Gujar N, Jolesz FA, Walker MP (2007) A deficit in the ability to form new human memories without sleep. Nat Neurosci 10:385–392

    CAS  PubMed  Google Scholar 

  • Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S (2010) Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol 47:15–22

    PubMed  Google Scholar 

  • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008) Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61–73

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Z, Lange DJ, Voustianiouk A, MacGrogan D, Ho L et al (2006) A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci 7:29

    PubMed  PubMed Central  Google Scholar 

  • Ziegler DR, Ribeiro LC, Hagenn M, Siqueira IR, Araujo E, Torres IL, Gottfried C, Netto CA, Goncalves CA (2003) Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res 28:1793–1797

    CAS  PubMed  Google Scholar 

  • Zilberter T (2011) Carbohydrate-biased control of energy metabolism: the darker side of the selfish brain. Front. Neuroenergetics 3:8

    Google Scholar 

  • Zurlo F, Larson K, Bogardus C, Ravussin E (1990) Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 86:1423–1427

    CAS  PubMed  PubMed Central  Google Scholar 

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Farooqui, A. (2014). The Effects of Diet, Exercise, and Sleep on Brain Metabolism and Function. In: Inflammation and Oxidative Stress in Neurological Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-04111-7_1

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