Abstract
The Bischler–Möhlau indole synthesis, also known as the Bischler indole synthesis, refers to the synthesis of 2-arylindoles from the cyclization of α- arylamino-ketones and excess anilines.
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Möhlau, R. Ber. 1881, 14, 171–175. Möhlau, a German chemist, worked extensively in the dye industry.
Bischler, A.; Fireman, P. Ber. 1893, 26, 1346–1349. Augustus Bischler (1865–1957) was born in Southern Russia. He studied in Zurich with Arthur Hantzsch. He discovered the Bischler–Napieralski reaction while studying alkaloids at Basel Chemical Works, Switzerland with his coworker, B. Napieralski.
Sundberg, R. J. The Chemistry of Indoles; Academic Press: New York, 1970, pp 164. (Book).
Buu-Hoï, N. P.; Saint-Ruf, G.; Deschamps, D.; Bigot, P. J. Chem. Soc. (C) 1971, 2606–2609.
Houlihan, W. J., Ed.; The Chemistry of Heterocyclic Compounds, Indoles (Part 1), Wiley: New York, 1972. (Book).
Bigot, P.; Saint-Ruf, G.; Buu-Hoï, N. P. J. Chem. Soc., Perkin 1 1972, 2573–2576.
Bancroft, K. C. C.; Ward, T. J. J. Chem. Soc., Perkin 1 1974, 1852–1858.
Coïc, J. P.; Saint-Ruf, G.; Brown, K. J. Heterocycl. Chem. 1978, 15, 1367–1371.
Henry, J. R.; Dodd, J. H. Tetrahedron Lett. 1998, 39, 8763–8764.
Pchalek, K.; Jones, A. W.; Wekking, M. M. T.; Black, D. S. C. Tetrahedron 2005, 61, 77–82.
Sridharan, V.; Perumal, S.; Avendaño, C.; Menéndez, J. C. Synlett 2006, 91–95.
Zhang, J. Bischler–Möhlau Indole Synthesis, In Name Reactions in Heterocyclic Chemistry II; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2011, pp 84–90. (Review).
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Li, J.J. (2014). Bischler–Möhlau indole synthesis. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_26
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DOI: https://doi.org/10.1007/978-3-319-03979-4_26
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